Results 11 to 20 of about 640,319 (303)
Hepatobiliary Impairments in Patients with Inflammatory Bowel Diseases: The Current Approach
Gastroenterology Insights, 2022 Inflammatory bowel disease (IBD) refers to chronic conditions with a low mortality but high disability. The multisystemic nature of these diseases can explain the appearance of some extraintestinal manifestations, including liver damage.
Vlad Alexandru Ionescu +4 more
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Drug-induced acute liver disease [PDF]
Postgraduate Medical Journal, 1989 Summary Fifty-three patients with drug-induced acute liver disease are reported. There were 35 females and 18 males with a mean age of 41 years. All but one patient had jaundice or hyperbilirubinaemia and 51 had abnormal liver enzymes.
M G, Lee, B, Hanchard, N P, Williams
openaire +2 more sources
The iron-chelating drug M30 down-regulates carbon tetrachloride (CCI4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro [PDF]
, 2013 Topic: 2 Acute Liver FailureThis journal suppl. entitled: APASL Liver Week 2013BACKGROUND/AIMS: The novel multifunctional brain permeable ironchelator M30 possesses neuroprotective activities against several insults applicable to various ...
Fung, ML +8 more
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The Journal of Clinical Pharmacology, 1981 Abstract: All cases of diagnosed drug‐induced hepatitis were identified in a series of 66,995 hospitalized medical and surgical patients. There were 11 cases which resulted from drugs taken for the first time in hospital and an additional nine cases resulting from drugs taken by patients prior to admission. Liver damage occurred relatively often after
H, Jick, A M, Walker, J, Porter
+7 more sources
COVID-19-associated liver injury, role of drug therapy and management: a review
Egyptian Liver Journal, 2022 The ongoing COVID-19 pandemic is known to affect several body organs, including the liver. This results from several factors such as direct effect of SARS-CoV-2 on the liver, side effects of drug therapy and pre-existing liver diseases.
Chinonyerem O. Iheanacho +1 more
doaj +1 more source
Role of High-Mobility Group Box-1 in Liver Pathogenesis [PDF]
, 2019 High-mobility group box 1 (HMGB1) is a highly abundant DNA-binding protein that can relocate to the cytosol or undergo extracellular release during cellular stress or death. HMGB1 has a functional versatility depending on its cellular location.
Huda, Nazmul +3 more
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The Hepatoprotective and Hepatotoxic Roles of Sex and Sex-Related Hormones
Frontiers in Immunology, 2022 Most liver diseases, including acute liver injury, drug-induced liver injury, viral hepatitis, metabolic liver diseases, and end-stage liver diseases, are strongly linked with hormonal influences.
Linlin Xu +7 more
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Modeling viral infectious diseases and development of antiviral therapies using human induced pluripotent stem cell-derived systems [PDF]
, 2015 The recent biotechnology breakthrough of cell reprogramming and generation of induced pluripotent stem cells (iPSCs), which has revolutionized the approaches to study the mechanisms of human diseases and to test new drugs, can be exploited to generate ...
Barzon, Luisa +6 more
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Pregnane X receptor in drug-induced liver injury: Friend or foe?
Liver Research, 2018 The pregnane X receptor (PXR) is a ligand activated nuclear receptor that is highly expressed in the liver and regulates many cellular functions including drug metabolism, endobiotic metabolism, oxidative stress response, apoptosis, inflammation, cell ...
Amina I. Shehu, Xiaochao Ma
doaj +1 more source
Recent Progress of Activity-Based Fluorescent Probes for Imaging Leucine Aminopeptidase
Biosensors, 2023 Leucine aminopeptidase (LAP) is an important protease that can specifically hydrolyze Leucine residues. LAP occurs in microorganisms, plants, animals, and humans and is involved in a variety of physiological processes in the human body.
Ze-Jun Li +6 more
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