Results 191 to 200 of about 356,562 (324)

Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs

Advanced Healthcare Materials, EarlyView.
This study demonstrates the safety of repeated application of three types of microarray patches (MAPs), hydrogelforming, dissolving, and implantable, over four weeks in miniature pigs. No adverse skin or systemic effects were observed, supporting the clinical potential of MAPs as safe and effective drug delivery platforms.
Qonita Kurnia Anjani, Aaron R. J. Hutton, Peter E. McKenna, Eneko Larrañeta, Ryan F. Donnelly   +4 more
wiley   +1 more source

Drug-induced liver injury secondary to rituximab use. [PDF]

Oxf Med Case Reports
Armendariz-Pineda SM, Vargas-Beltran AM, Corredor-Nassar MJ, Gamboa-Domínguez A, Santos-Reyes DA, Cordova-Gallardo J.   +5 more
europepmc   +1 more source

Idiosyncratic Drug-Induced Liver Injury and the Role of Inflammatory Stress with an Emphasis on an Animal Model of Trovafloxacin Hepatotoxicity

, 2010
Patrick J. Shaw, Patricia E. Ganey, Robert A. Roth   +2 more
openalex   +1 more source

An Organ‐on‐Chip Platform for Strain‐Controlled, Tissue‐Specific Compression of Cartilage and Mineralized Osteochondral Interface to Study Mechanical Overloading in Osteoarthritis

Advanced Healthcare Materials, EarlyView.
A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi, Anastasiya Börsch, Paola Occhetta, Robert Ivanek, Martin Ehrbar, Lisa Krattiger, Philipp Oertle, Marko Loparic, Ivan Martin, Marco Rasponi, Andrea Barbero   +10 more
wiley   +1 more source

Semaglutide-Induced Hepatic Injury: A Rare Case of Drug Induced Liver Injury. [PDF]

Clin Case Rep
Kundu R, Shtoff L.
europepmc   +1 more source

Engineering a Human‐Sized Common Bile Duct Prototype with Regenerative Potential: In Vitro Evaluation of Mechanics, Function, Degradation, and Immune Modulation

Advanced Healthcare Materials, EarlyView.
This study presents a multiphasic bile duct construct composed of biocompatible materials and cells, featuring an inner layer that supports biliary epithelium growth, a middle layer providing mechanical strength, and an outer cell‐permissive layer designed to support future in vivo integration.
Mattia Pasqua, Marianna Barbuto, Matteo Calligaris, Roberto Di Gesù, Duilio Pagano, Rosalia Busà, Salvatore Gruttadauria, Simone Dario Scilabra, Antonio D'Amore, Maria Giovanna Francipane   +9 more
wiley   +1 more source

Autoimmune Hepatitis and Drug-Induced Liver Injury in Japan. [PDF]

J Clin Med
Nishikawa H, Kim SK, Asai A.
europepmc   +1 more source

S1881 The Therapeutic Efficacy of Ursodeoxycholic Acid (UDCA) in Drug-Induced Liver Injury: Results of a Randomized Controlled Trial

, 2010
Yi‐Shin Huang
openalex   +1 more source

Commentary: proteomics and drug‐induced liver injury [PDF]

, 2012
Péter Ferenci
openalex   +1 more source

Multiscale Profiling of Nanoscale Metal‐Organic Framework Biocompatibility and Immune Interactions

Advanced Healthcare Materials, EarlyView.
A multi‐scale, hierarchical ‘Safety‐by‐Design’ pipeline combining machine learning, ex vivo human blood assays, and in vivo models enables the systematic immunotoxicity and biocompatibility profiling of nanoscale metal‐organic frameworks, accelerating their safe clinical translation. Abstract The clinical translation of metal‐organic frameworks (MOFs) –
Yunhui Zhuang, Bárbara B. Mendes, Dhruv Menon, Jhenifer Oliveira, Xu Chen, Fatma Demir Duman, João Conniot, Sergio Mercado, Xiewen Liu, Shi‐Yuan Zhang, João Conde, Rachel E. Hewitt, David Fairen‐Jimenez   +12 more
wiley   +1 more source