Results 211 to 220 of about 245,919 (260)

Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control

Advanced Science, EarlyView.
Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang, Xiangyang Zhan, Jiexiang Zhang, Mingyue Tan, Chuanmin Chu, Guanqun Ju, Xinyu Zhai, Jianyi Gu, Huirong Zhu, Dongliang Xu   +9 more
wiley   +1 more source

Machine Learning-Based Models to Predict Drug-Induced Liver Injury (DILI) to Assist Medicinal Chemistry. [PDF]

J Med Chem
Evangelista D, Nelson E, Tehan B, Bagnolini G, Roberti M, Bottegoni G.   +5 more
europepmc   +1 more source

Semaglutide and Its Potential Hepatoprotective Effects Against Acute Drug-Induced Liver Injury. [PDF]

Cureus
Charatsi E, Liberopoulos E, Pergialiotis V, Kontzoglou K, Kykalos S, Iliopoulos D.   +5 more
europepmc   +1 more source

Obstructive Jaundice due to a Periportal Tuberculous Mass Complicated by Anti-Tuberculous Drug-Induced Liver Injury: A Case Report From a Low-Resource Setting. [PDF]

Clin Case Rep
Lema GD, Chanie Y, Yanore MT, Mengistu SB, Kotisso AB, Zena D, Gebreeyesus ST, Gared TM, Chekol NS, Muhammed EU.   +9 more
europepmc   +1 more source

Confident but unsupported: auditing large language models against supplied evidence boundaries in drug-induced liver injury assessment. [PDF]

Front Public Health
Shi J, Ma Y, Liu Y, Shi B.
europepmc   +1 more source

Leflunomide-Induced Severe Cutaneous Adverse Reaction, Severe Drug-Induced Liver Injury With Hepatic Encephalopathy, and Hemophagocytic Lymphohistiocytosis: A Case Report. [PDF]

Cureus
Moparthi KP, Jampani S.
europepmc   +1 more source

Insights into the Biochemical and Immune Mechanisms in Drug-Induced Liver Injury Pathogenesis. [PDF]

Chem Res Toxicol
Saville E, Wells G, Farrell L, Naisbitt DJ, Meng X.   +4 more
europepmc   +1 more source