Results 41 to 50 of about 524,198 (385)

High-Fidelity Drug Induced Liver Injury Screen Using Human PSC-derived Organoids.

Gastroenterology, 2020
BACKGROUND & AIMS Preclinical identification of compounds at risk of causing drug induced liver injury (DILI) remains a significant challenge in drug development, highlighting a need for a predictive human system to study complicated DILI mechanism and ...
T. Shinozawa, M. Kimura, Yuqi Cai, Norikazu Saiki, Yosuke Yoneyama, Rie Ouchi, H. Koike, Mari Maezawa, Ran-ran Zhang, Andrew Dunn, Autumn Ferguson, Shodai Togo, Kyle Lewis, Wendy L Thompson, A. Asai, T. Takebe   +15 more
semanticscholar   +1 more source

Role of Corticosteroids in Drug-Induced Liver Injury. A Systematic Review

Frontiers in Pharmacology, 2022
Introduction: Apart from cessation of the implicated agent leading to drug-induced liver injury (DILI), there is no standard therapy for DILI. Corticosteroids have been used in DILI, although their efficacy is unclear.
E. Björnsson, V. Vučić, G. Stirnimann, M. Robles-Díaz   +3 more
semanticscholar   +1 more source

Genetic polymorphisms of interleukin-10 and transforming growth factor-β1 and antituberculosis drugs-induced liver injury [PDF]

, 2017
Purpose: Drug-induced liver injury is one of the serious adverse reactions resulting in severe morbidity and discontinuation of med ications. Previously, IL-10 gene polymorphism has been reported to be associated with diclofenac-induced hepatitis.
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core   +1 more source

A new framework for advancing in drug-induced liver injury research. The Prospective European DILI Registry

Liver international (Print), 2022
No multi‐national prospective study of drug‐induced liver injury (DILI) has originated in Europe. The design of a prospective European DILI registry, clinical features and short‐term outcomes of the cases and controls is reported.
Einar S. Björnsson, C. Stephens, E. Atallah, M. Robles-Díaz, I. Álvarez-Álvarez, A. Gerbes, S. Weber, G. Stirnimann, G. Kullak-Ublick, H. Cortez‐Pinto, Jane I. Grove, M. Lucena, Raúl J. Andrade, G. Aithal   +13 more
semanticscholar   +1 more source

Drug-Induced Liver Injury: Highlights and Controversies in the Recent Literature

Drug Safety, 2021
Drug-induced liver injury (DILI) remains an important, yet challenging diagnosis for physicians. Each year, additional drugs are implicated in DILI and this year was no different, with more than 1400 articles published on the subject.
J. Clinton, Sara Kiparizoska, S. Aggarwal, S. Woo, William Davis, J. Lewis   +5 more
semanticscholar   +1 more source

Drug-Induced Liver Injuries (Clinical Guidelines for Physicians)

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2019
Aim. Clinical guidelines for the management of adult patients suffering from drug-induced liver injuries (DILI) are intended for all medical specialists, who treat such patients in their clinical practice.Key findings.
Vladimir T. Ivashkin, Andrey Yu. Baranovsky, Karina L. Raikhelson, Lyudmila K. Palgova, Marina V. Maevskaya, Elina A. Kondrashina, Natalya V. Marchenko, Tatyana P. Nekrasova, Igor G. Nikitin   +8 more
doaj   +1 more source

Case series and review of Ayurvedic medication induced liver injury

BMC Complementary Medicine and Therapies, 2021
Background Complementary and alternative medicine use among Americans is prevalent. Originating in India, Ayurvedic medicine use in the United States has grown 57% since 2002.
Christopher M. Karousatos, Justin K. Lee, David R. Braxton, Tse-Ling Fong   +3 more
doaj   +1 more source

Antifungal Drugs and Drug-Induced Liver Injury: A Real-World Study Leveraging the FDA Adverse Event Reporting System Database

Frontiers in Pharmacology, 2022
Aims: We aimed to estimate the risk of drug-induced liver injury (DILI) from various antifungal treatments with azoles and echinocandins causing in real-world practice. Methods: We performed disproportionality and Bayesian analyses based on data from the
Zhi-xuan Zhou, Xue-dong Yin, Yu Zhang, Qi-hui Shao, X. Mao, Wen-juan Hu, Yunfang Shen, Bin Zhao, Zhi-ling Li   +8 more
semanticscholar   +1 more source

Treatment with gefitinib after erlotinib-induced liver injury: a case report [PDF]

, 2011
INTRODUCTION: Gefitinib and erlotinib have minor differences in their chemical structures, and thus it remains unclear whether the hepatotoxicity induced by one compound is affected by the other.
Iida Tetsuya, Katsumi Nakatomi, Shigeru Kohno, Yoichi Nakamura   +3 more
core   +2 more sources

Rational choice of hepatoprotectors for drug-induced liver injury

Gastroenterologìa, 2022
The article deals with a review of the current literature on the clinical use of hepatoprotectors in drug-induced liver injury. The literature was searched in Scopus, Web of Science, PubMed and other databases. Risk factors, pathogenetic mechanisms of li­
H.V. Osyodlo, M.P. Boichak, O.O. Fedorova   +2 more
doaj   +1 more source