Chinese MedicineBackground Prediabetes mellitus (PreDM) is a high-risk state for developing type 2 diabetes mellitus (T2DM) and often goes undiagnosed, which is closely associated with obesity and characterized by insulin resistance that urgently needs to be treated ...
Qin Lan +7 more
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The iron-chelating drug M30 down-regulates carbon tetrachloride (CCI4)-induced hepatic oxidative stress, inflammation and apoptosis in vitro [PDF]
, 2013 Topic: 2 Acute Liver FailureThis journal suppl. entitled: APASL Liver Week 2013BACKGROUND/AIMS: The novel multifunctional brain permeable ironchelator M30 possesses neuroprotective activities against several insults applicable to various ...
Fung, ML +8 more
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Drug Induced Hepatotoxicity – An Ongoing Challenge
Journal of Bahria University Medical and Dental College, 2021 Drug induced liver injury is one of the main factor of liver failure and acute liver damage world wide with high incidence in western countries. Liver injury can be intrinsic (dose dependant) or idiosyncratic (dose independent).
Mehr Fatima, Syed Ijaz Hussain Zaidi
doaj +1 more source
A case report of vanishing bile duct syndrome after exposure to pexidartinib (PLX3397) and paclitaxel. [PDF]
, 2019 Pexidartinib (PLX3397) is a small molecule tyrosine kinase and colony-stimulating factor-1 inhibitor with FDA breakthrough therapy designation for tenosynovial giant-cell tumor, and currently under study in several other tumor types, including breast ...
Chien, A Jo +5 more
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Paracetamol-induced liver injury modelled in Xenopus laevis embryos [PDF]
, 2019 Introduction: Failure to predict drug-induced liver injury (DILI) remains a major contributing factor to lead compound drop-out during drug development. Xenopus embryos are amenable for early stage medium throughput small molecule screens and so have the
Saide, Katy +2 more
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Features of Autoimmune Hepatitis in Patients With Drug-induced Liver Injury [PDF]
, 2017 BACKGROUND & AIMS: Drug-induced liver injury (DILI) has features similar to those of other liver diseases including autoimmune hepatitis (AIH). We aimed to characterize the clinical and autoimmune features of liver injury caused by nitrofurantoin ...
Chalasani, Naga +8 more
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Lansoprazole Ameliorates Isoniazid-Induced Liver Injury
PharmaceuticalsIsoniazid is a first-line drug in antitubercular therapy. Isoniazid is one of the most commonly used drugs that can cause liver injury or acute liver failure, leading to death or emergency liver transplantation.
Eri Wakai +5 more
doaj +1 more source
Attenuation of ischemic liver injury by prostaglandin E
, 1998 Background: Prostaglandin has been reported to have protective effects against liver injury. Use of this agent in clinical settings, however, is limited because of drugrelated side effects.
Ishizaki, N +8 more
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Drug‐Induced Liver Injury in GI Practice
Hepatology Communications, 2020 Although drug‐induced liver injury (DILI) is a rare clinical event, it carries significant morbidity and mortality, leaving it as the leading cause of acute liver failure in the United States.
Naemat Sandhu, Victor Navarro
doaj +1 more source
Relationship Between Characteristics of Medications and Drug-Induced Liver Disease Phenotype and Outcome [PDF]
, 2014 Background & Aims: It is not known if specific characteristics of medication are associated with type of drug-induced liver injury (DILI) or outcome.
Chalasani, Naga +8 more
core +1 more source