Results 61 to 70 of about 524,198 (385)

Ayurvedic Drug-Induced Liver Injury

American Journal of Gastroenterology, 2017
Drug induced liver injury is responsible for 50% of acute liver failure in developed countries. Ayurvedic and homeopathic medicine have been linked to liver injury. This case describes the first documented case of Punarnava mandur and Kanchnar guggulu causing drug induced liver injury. Drug induced liver injury may be difficult to diagnosis, but use of
Dalal, Kunal K, Holdbrook, Thomas, Peikin, Steven R   +2 more
openaire   +2 more sources

Challenges and Future of Drug-Induced Liver Injury Research—Laboratory Tests

International Journal of Molecular Sciences, 2022
Drug-induced liver injury (DILI) is a rare but potentially severe adverse drug event, which is also a major cause of study cessation and market withdrawal during drug development. Since no acknowledged diagnostic tests are available, DILI diagnosis poses
S. Weber, A. Gerbes
semanticscholar   +1 more source

Xenobiotic metabolism: the effect of acute kidney injury on non-renal drug clearance and hepatic drug metabolism. [PDF]

, 2014
Acute kidney injury (AKI) is a common complication of critical illness, and evidence is emerging that suggests AKI disrupts the function of other organs.
Abosaif, Andres-Hernando, Andres-Hernando, Barbara Philips, Boucher, Bougle, Brown, Chan, Chawla, Chung, Doi, Dowling, Dreisbach, Dreisbach, English, Fadillioglu, Gardiner, Gertz, Golab, Group, Gurley, Hassoun, Heinemeyer, Heinemeyer, Iain MacPhee, Izuwa, John Dixon, Karim, Katie Lane, Kirwan, Kirwan, Klein, Kramer, Krueger, Kunihara, Kunuzova, Lane, Lash, Leblanc, Lee, Lee, Lohr, Martyn, Mastorakos, Meier-Hellmann, Michaud, Michaud, Miyazawa, Muntane-Relat, Murakami, Naud, Naud, Nicholson, Nolin, Nolin, Okabe, Okabe, Okabe, Owen, O’Shaunessy, Park, Park, Philips, Power, Schneider, Serteser, Shi, Shibata, Smith, Soni, Spapen, Srinivas, Sun, Tanabe, Tian, Venkatesh, Wang, Whelton, Wilkinson, Wilson, Yamaguchi, Yoshitani, Yu   +82 more
core   +2 more sources

Drug induced liver injury: do we still need a routine liver biopsy for diagnosis today?

Annals of Hepatology, 2014
For the pathologist, the diagnosis of drug induced liver injury (DILI) is challenging, because histopathological features mimic all primary hepatic and biliary diseases, lacking changes that are specific for DILI.
Rolf Teschke, Christian Frenzel
doaj   +1 more source

Acetaminophen Hepatotoxicity: Paradigm for Understanding Mechanisms of Drug-Induced Liver Injury.

Annual Review of Pathology
Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in western countries, and, because of translational relevance of animal models, APAP is mechanistically the most studied drug.
H. Jaeschke, A. Ramachandran
semanticscholar   +1 more source

A dog model for acetaminophen-induced fulminant hepatic failure. [PDF]

, 1989
The development of a large animal model of fulminant hepatic failure produced with acetaminophen that should be useful in the development and evaluation of potential medical therapies for the important clinical problem of fulminant hepatic failure is ...
Barone, M, Demetris, J, Francavilla, A, Makowka, L, Polimeno, L, Prelich, J, Starzl, TE, Van Thiel, DH   +7 more
core   +1 more source

Impact of Non-Alcoholic Simple Fatty Liver Disease on Antituberculosis Drug-Induced Liver Injury

Infection and Drug Resistance, 2021
Yi-Hui Liu,1 Yan Guo,2 Hong Xu,1 Hui Feng,1 Dong-Ya Chen1 1Department of Digestive Hepatology, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, 310003, People’s Republic of China; 2Department of Gastroenterology, Hangzhou Third Hospital, Hangzhou ...
Liu YH, Guo Y, Xu H, Feng H, Chen DY
doaj  

Evaluation of drug-induced liver injury as etiology for acute liver failure in Brazil

Annals of Hepatology, 2021
Introduction and objectives: Little is known about the etiology of acute liver failure (ALF) in Latin America. The objective of this paper is to investigate the main etiologies of ALF in Brazil, including Drug Induced Liver Injury (DILI) using stringent ...
Genario Santos, Estela Regina Ramos Figueira, Luiz Augusto Carneiro D’Albuquerque, Paulo Bittencourt Lisboa, Marcio Dias de Almeida, Norma Arteiro Filgueira, Ilka Boin, Gilda Porta, Rita de Cássia Martins Alves da Silva, Cyntia Ferreira Gomes Viana, Luciana Costa Faria, Mario Reis Alvares-da-Silva, Adriano Claudio Pereira de Moraes, Daphne Benatti Goncalves Morsoletto, Liana Codes, Raymundo Paraná   +15 more
doaj   +1 more source

Inhibition of CYP1A1 Alleviates Colchicine-Induced Hepatotoxicity

Toxins
Colchicine, a natural compound extracted from Colchicum autumnale, is a phytotoxin, but interestingly, it also has multiple pharmacological activities.
Ruoyue Huang, Jingyi Duan, Wen Huang, Yan Cheng, Beiwei Zhu, Fei Li   +5 more
doaj   +1 more source

Safety of drugs

Репродуктивная эндокринология, 2018
Liver is the main organ that plays an important role in the biotransformation of medicine in human body. Therefore, drug-induced liver injuries are much more common than official medical statistics show in different countries and on different continents.
А. А. Суханова, Ю. Н. Мельник, А. Б. Гордийчук   +2 more
doaj   +1 more source