Results 91 to 100 of about 11,641 (246)

Subtoxic Concentrations of Hepatotoxic Drugs Lead to Kupffer Cell Activation in a Human In Vitro Liver Model [PDF]

, 2015
Drug induced liver injury (DILI) is an idiosyncratic adverse drug reaction leading to severe liver damage. Kupffer cells (KC) sense hepatic tissue stress/damage and therefore could be a tool for the estimation of consequent effects associated with DILI ...
Burkhardt, Britta, Damm, Georg, Kegel, Victoria, Liu, Jia L., Nüssler, Andreas K., Pfeiffer, Elisa, Seehofer, Daniel, Zeilinger, Katrin   +7 more
core   +4 more sources

PP022—Variations in drug-induced liver injury (DILI) between different prospective dili registries

Clinical Therapeutics, 2013
e24 Volume 35 Number 8S PP022—VARIATIONS IN DRUG-INDUCED LIVER INJURY (DILI) BETWEEN DIFFERENT PROSPECTIVE DILI REGISTRIES I. Medina-Caliz; A. Gonzalez-Jimenez; F. Bessone; N. Hernandez; A. Sanchez; M. Di Pace; M. Arrese; J.R. Brahm; A. Ruiz; J. Arancibia; D. Kershenobich; A. Loaeza; M. Girala; N. Mendez-Sanchez; M. Davalos; M. Lizarzabal; E.
Milagros Dávalos, A. Ruíz, J.R. Brahm, Inmaculada Medina-Caliz, Edgardo Mengual, A. Loaeza, Marcos Girala, D. Kershenobich, Nelia Hernández, Maribel Lizarzábal, Fernando Bessone, M. di Pace, Nahum Méndez-Sánchez, Raúl J. Andrade, Adriana Sánchez, Mercedes Robles-Díaz, Juan P Arancibia, A. González-Jiménez, M.I. Lucena, Marco Arrese, Camilla Stephens   +20 more
openaire   +2 more sources

Drug induced liver injury: accuracy of diagnosis in published reports

Annals of Hepatology, 2014
The diagnosis of drug induced liver injury (DILI) is based primarily on the exclusion of alternative causes. To assess the frequency of alternative causes in initially suspected DILI cases, we searched the Medline database with the following terms: drug ...
Rolf Teschke, Christian Frenzel, Albrecht Wolff, Axel Eickhoff, Johannes Schulze   +4 more
doaj   +1 more source

Epigallocatechin-3-gallate Mo nanoparticles (EGM NPs) efficiently treat liver injury by strongly reducing oxidative stress, inflammation and endoplasmic reticulum stress

Frontiers in Pharmacology, 2022
Drug-induced liver injury (DILI) is a serious clinical disease associated with reactive oxygen species (ROS) burst and subsequent inflammatory responses.
Yunrong Yang, Yunrong Yang, Min Liu, Min Liu, Tianjiao Zhao, Tianjiao Zhao, Qiaohui Chen, Qiaohui Chen, Yuqi Yang, Yuqi Yang, Shuya Wang, Shuya Wang, Jinping Zhang, Jinping Zhang, Guiming Deng, Kewei Sun, Yayun Nan, Ke Cao, Kelong Ai, Kelong Ai, Qiong Huang, Qiong Huang   +21 more
doaj   +1 more source

Safety and Efficacy of the NMDA‐2b‐Selective Negative Allosteric Modulator BI 1569912: A Phase Ib Randomized Trial in Major Depressive Disorder

Clinical Pharmacology &Therapeutics, EarlyView.
Selective N‐methyl‐D‐aspartate receptor subunit 2b negative allosteric modulators (NR2B NAMs) are being explored as potential new treatment options for major depressive disorder (MDD). This Phase Ib, randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted in adults (N = 59) with moderate‐to‐severe MDD and insufficient response ...
Roger S. McIntyre, Gerard Sanacora, David P. Walling, Elan A. Cohen, Shishuka Malhotra, Holger Rosenbrock, Manuela Schmitz, Andreas Scholz, Sigurd D. Süssmuth, Franco De Crescenzo   +9 more
wiley   +1 more source

Incidence of drug-induced liver injury in medical inpatients [PDF]

, 2018
Objectives: Drug-induced liver injury (DILI) is a common concern. However, data on DILI epidemiology in inpatients are sparse. Methods: To investigate the incidence of DILI, we screened all patients in the pharmacoepidemiological inpatient database ...
Cavallaro, Marzia, Fattinger, Karin, Folkers, Gerd, Meier, Peter, Meier, Yvonne, Pauli-Magnus, Christiane, Roos, Malgorzata   +6 more
core  

Features of Autoimmune Hepatitis in Patients With Drug-induced Liver Injury [PDF]

, 2017
BACKGROUND & AIMS: Drug-induced liver injury (DILI) has features similar to those of other liver diseases including autoimmune hepatitis (AIH). We aimed to characterize the clinical and autoimmune features of liver injury caused by nitrofurantoin ...
Chalasani, Naga, de Boer, Ynto S., Drug-Induced Liver Injury Network., Hoofnagle, Jay H., Kleiner, David E., Kosinski, Andrzej S., Long, Nanye, Urban, Thomas J., Zhao, Zhen   +8 more
core   +2 more sources

A Case of Suspected Lisdexamfetamine (Vyvanse) Drug-Induced Liver Injury [PDF]

, 2023
Amphetamines are a well-established cause of liver injury though the typical presentation is that of illicit drug abuse rather than liver injury occurring in a prescribed setting.1 Lisdexamfetamine (Vyvanse) is one of the most commonly prescribed ...
Ahmed, MD, Monjur, Bilello, MD, Justin, Flerova, MD, Elizaveta, Kishfy, MD, Louis   +3 more
core   +2 more sources

Functional foods and bioactive compounds: a comprehensive review on their role in mitigating drug-induced liver injury

Frontiers in Nutrition
Drug-induced liver injury (DILI) has become a serious public health issue worldwide. Many drugs (chemotherapy drugs, fever-reducing medications, nonsteroidal anti-inflammatory drugs, immunosuppressants, antibiotics, antivirals, and antineoplastic drugs ...
Jin-Wei Zhao, Wei-Yi Zhao, Meng Zhao, Lu Yu   +3 more
doaj   +1 more source

Quantitative Systems Toxicology Predicts Ivacaftor‐Induced Oxidative Stress Contributes to CFTR Modulator Hepatotoxicity

Clinical Pharmacology &Therapeutics, EarlyView.
Cystic fibrosis (CF) is a chronic hereditary disease that affects tens of thousands of people worldwide. The introduction of CFTR modulator therapies such as elexacaftor/tezacaftor/ivacaftor (ETI) has significantly improved the quality of life of people with CF.
Alan Shi, Cole Cornwell, Kyunghee Yang, Paul M. Beringer   +3 more
wiley   +1 more source