Results 91 to 100 of about 12,091 (224)

Reliability of causality assessment for drug, herbal and dietary supplement hepatotoxicity in the Drug‐Induced Liver Injury Network (DILIN) [PDF]

, 2014
Background & AimsBecause of the lack of objective tests to diagnose drug‐induced liver injury (DILI), causality assessment is a matter of debate. Expert opinion is often used in research and industry, but its test–retest reliability is unknown.
Barnhart, Huiman X., Chalasani, Naga, Davern, Timothy J., Fontana, Robert J., Hayashi, Paul H., Hoofnagle, Jay H., Reddy, K. Rajender, Rockey, Don C., Stolz, Andrew A., Talwalkar, Jayant A.   +9 more
core   +3 more sources

Short communication: Dynamic chemical labelling allows the measurement of the paracetamol toxicity biomarker microRNA‐122 in hospital clinical laboratories

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 612-618, February 2026.
MicroRNA‐122 (miR‐122) is a sensitive biomarker for paracetamol‐induced liver injury. This study assessed the diagnostic performance of dynamic chemical labelling (DCL) combined with an immunoassay platform to quantify miR‐122 in human serum, as a proof‐of‐concept for hospital use.
Samar Alzeer, Antonio Marin‐Romero, Bárbara López‐Longarela, Juan J. Guardia‐Monteagudo, F. Javier Lopez‐Delgado, Salvatore Pernagallo, Juan J. Diaz‐Mochon, Mavys Tabraue‐Chavez, Kathleen Scullion, James W. Dear   +9 more
wiley   +1 more source

Efek Pemberian Metilprednisolon Oral Terhadap Gambaran Histopatologik Hati Tikus Wistar (Rattus Norvegicus) [PDF]

, 2016
: Drug-induced liver injury (DILI) is an adverse drug reaction which vary in its clinical manifestations, ranging from an asymptomatic increase in liver enzymes to fulminant hepatic failure.
Durry, M. F. (Meilany), Lintong, P. M. (Poppy), Rifaldi, M. (Muhammad)   +2 more
core  

Risk of acute and serious liver injury associated to nimesulide and other NSAIDs: data from drug-induced liver injury case-control study in Italy [PDF]

, 2016
Aim: Drug-induced liver injury is one of the most serious adverse drug reactions and the most frequent reason for restriction of indications or withdrawal of drugs. Some nonsteroidal anti-inflammatory drugs (NSAIDs) were withdrawn from the market because
Arzenton, E., Bonaiuti, R., Bortolami, O., Capuano, A., Conforti, A., Donati, M., Lenti, M.C., Leone, R., Moretti, U., Motola, D., Rafaniello, C., Sportiello, L., Vaccheri, A., Vannacci, A.   +13 more
core   +2 more sources

Metabolite Profiling and Anticancer Evaluation of Iraqi Haloxylon articulatum Halophyte via LC–HRMS/MS, Molecular Docking, and ADMET Analysis

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
This study investigates the phytochemical composition and biological activities of a hydroalcoholic extract of Haloxylon articulatum. LC‐HRMS/MS identified diverse bioactive compounds, notably N‐caffeoyltyramine and sinapoyltyramine. The extract exhibited strong antioxidant activity and significant cytotoxic effects against gastric cancer cell lines ...
Jihen Abidi, Amal Ben Hassena, Rania Ben Hmida, Łukasz Kulinowski, Erdi Can Aytar, Reyedh R. Al‐Rashidi, Mohamed Bouaziz   +6 more
wiley   +1 more source

Natural history and outcomes in drug induced autoimmune hepatitis [PDF]

, 2016
Aim: Drug-induced autoimmune hepatitis (DIAIH) remains poorly characterized. Our aim was to assess natural history and outcomes in DIAIH. Methods: This was a retrospective cohort study.
Alla, Alvarez, Andrade, Appleyard, Björnsson, Björnsson, Björnsson, Castiella, Castiella, Cohen, Danan, Feld, Heneghan, Heurgué, Kennedy, Kocman, Lawrenson, Licata, Lucena, MacGregor, Manns, Navarro, Roberts, Russo, Sakaan, Scully, Sharp, Shepherd, Sugimoto, Suzuki, Unzueta, Verma, Verma, Weiler-Normann   +33 more
core   +1 more source

Development of Prediction Models for Drug-Induced Cholestasis, Cirrhosis, Hepatitis, and Steatosis Based on Drug and Drug Metabolite Structures

Frontiers in Pharmacology, 2020
Drug-induced liver injury (DILI) is one of the major reasons for termination of drug development. Due to the importance of predicting DILI in early phases of drug development, diverse in silico models have been developed to filter out DILI-causing ...
Hyun Kil Shin, Myung-Gyun Kang, Daeui Park, Daeui Park, Tamina Park, Tamina Park, Seokjoo Yoon, Seokjoo Yoon   +7 more
doaj   +1 more source

Dicloxacillin and Flucloxacillin Inhibit Hepatic Uptake Transporters—In Vitro Investigations and Physiologically Based Pharmacokinetic Modeling

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Dicloxacillin and flucloxacillin are β‐lactamase‐resistant penicillin antibiotics that have been in clinical use for over 50 years. While both antibiotics are known to induce cytochrome P450 enzymes, there is limited information available regarding their interactions with drug transporters.
Noora Sjöstedt, Ogochukwu U. Amaeze, Jeroen J. M. W. van den Heuvel, Tore B. Stage, Jan B. Koenderink, Nina Isoherranen, Heidi Kidron, Erkka Järvinen   +7 more
wiley   +1 more source

Characterization of amoxicillin‐ and clavulanic acid‐specific T cells in patients with amoxicillin‐clavulanate–induced liver injury [PDF]

, 2015
Drug‐induced liver injury (DILI) frequently has a delayed onset with several human leukocyte antigen (HLA) genotypes affecting susceptibility, indicating a potential role for the adaptive immune system in the disease.
Abajo, Bomarrito, Britschgi, Cavani, Daly, Danan, Donaldson, Fontana, Jenkins, Kindmark, Li, Lucena, Lucena, Maria, Mauri-Hellweg, Metushi, Monshi, Mudnakudu Nagaraju, Naisbitt, Nattrass, O'Donohue, Pichler, Pichler, Sabat, Schaid, Singer, Spraggs, Stephens, Wu, Wu, Wuillemin, Wuillemin, Yanaba, Yanaba   +33 more
core   +1 more source

Autoimmune Hepatitis: Histopathological Diversity and Its Clinical Implications

Hepatology Research, Volume 56, Issue 2, Page 139-147, February 2026.
ABSTRACT Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease characterized by diverse clinical and histological manifestations. Accurate histopathological evaluation plays a critical role in determining disease activity, guiding treatment strategies, and predicting prognosis.
Mina Komuta, Kenichi Harada
wiley   +1 more source