Results 91 to 100 of about 12,201 (250)

Using free-text searching and ICD-10 codes to identify prospective patients with drug-induced liver injury [PDF]

, 2016
Drug-induced liver injury (DILI) is a rare cause of liver disease that is difficult to diagnose due to the lack of a confirmatory test. The Drug-Induced Liver Injury Network (DILIN) was developed to enroll patients with DILI to understand the clinical ...
Coffman, Cassandra
core   +1 more source

Development and validation of BCG vaccine‐induced novel granulomatous liver injury preclinical animal model

Animal Models and Experimental Medicine, EarlyView.
The study successfully developed and validated a granulomatous liver injury model using a high‐dose BCG vaccine, simulating hepatic tuberculosis and autoimmune granulomatous liver diseases. Pharmacokinetic analysis examined the metabolic behavior of first‐line antitubercular drugs (isoniazid and rifampicin) and their main metabolites under conditions ...
Swati Sharma, Abhishek Moudgil, Jyoti Grewal, Pankaj Khatri, Vishal Sharma, Madhumita Premkumar, Amanjit Bal, Dibyajyoti Banerjee, Amol N. Patil   +8 more
wiley   +1 more source

PP022—Variations in drug-induced liver injury (DILI) between different prospective dili registries

Clinical Therapeutics, 2013
e24 Volume 35 Number 8S PP022—VARIATIONS IN DRUG-INDUCED LIVER INJURY (DILI) BETWEEN DIFFERENT PROSPECTIVE DILI REGISTRIES I. Medina-Caliz; A. Gonzalez-Jimenez; F. Bessone; N. Hernandez; A. Sanchez; M. Di Pace; M. Arrese; J.R. Brahm; A. Ruiz; J. Arancibia; D. Kershenobich; A. Loaeza; M. Girala; N. Mendez-Sanchez; M. Davalos; M. Lizarzabal; E.
Milagros Dávalos, A. Ruíz, J.R. Brahm, Inmaculada Medina-Caliz, Edgardo Mengual, A. Loaeza, Marcos Girala, D. Kershenobich, Nelia Hernández, Maribel Lizarzábal, Fernando Bessone, M. di Pace, Nahum Méndez-Sánchez, Raúl J. Andrade, Adriana Sánchez, Mercedes Robles-Díaz, Juan P Arancibia, A. González-Jiménez, M.I. Lucena, Marco Arrese, Camilla Stephens   +20 more
openaire   +2 more sources

Drugs-induced liver injury associated with non-steroidal anti-inflammatory drugs: a case report and clinical insights

Alʹmanah Kliničeskoj Mediciny, 2019
Aim: To raise the awareness of general practitioners with special characteristics of the clinical manifestations of the drug-induced liver injury (DILI), which can manifest with various signs, symptoms and types of morphological injury, from asymptomatic
Yu. G. Sandler, E. V. Vinnitskaya, K. G. Saliev, S. G. Khomeriki, T. Yu. Кhaimenova   +4 more
doaj   +1 more source

Unresolved excess accumulation of myelin-derived cholesterol contributes to scar formation after spinal cord injury [PDF]

arXiv, 2022
Background: Spinal cord injury triggers complex pathological cascades, resulting in destructive tissue damage and incomplete tissue repair. Scar formation is generally considered as a barrier for regeneration in central nervous system (CNS), while the intrinsic mechanism of scar-forming after spinal cord injury has not been completed deciphered ...
arxiv  

Strategies for early prediction and timely recognition of drug-induced liver injury: The case of cyclin-dependent kinase 4/6 inhibitors [PDF]

, 2019
The idiosyncratic nature of drug-induced liver injury (Dili) represents a current challenge for drug developers, regulators and clinicians. The myriad of agents (including medications, herbals, and dietary supplements) with recognized Dili potential not ...
De Ponti F., Raschi E.
core   +1 more source

Adverse events associated with monoclonal antibodies used for treatment of COVID‐19: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims This review aimed to synthesise the evidence related to the incidence of serious and non‐serious adverse events with the use of monoclonal antibodies (mAbs) among COVID‐19 patients. Methods Databases were searched from January 2020 to September 2023 for randomized clinical trials (RCTs) that used mAbs for the treatment of COVID‐19 regardless of ...
Htet Htet, Han You Kyung, Ismail Abdul Sattar Burud, Heethal Jaiprakash, Thiruselvi Subramaniam, Igor Iezhitsa, Renu Agarwal   +6 more
wiley   +1 more source

Adverse drug reaction and organ damage: the liver [PDF]

, 2016
Drug-induced liver injury (Dili) is among the most challenging acute or chronic liver conditions to be handled by physicians. Despite its low incidence in the general population, Dili is a frequent cause of acute liver failure.
LICATA, Anna
core   +1 more source

Role of Ursodeoxycholic Acid in Treating and Preventing Idiosyncratic Drug-Induced Liver Injury. A Systematic Review

Frontiers in Pharmacology, 2021
Introduction: Treatment is generally not available for drug-induced liver injury (DILI) patients except in some specific circumstances. The management of DILI is based on the withdrawal of the responsible drug and monitoring the patients and only a few ...
Mercedes Robles-Díaz, Lana Nezic, Vesna Vujic-Aleksic, Vesna Vujic-Aleksic, Einar S. Björnsson, Einar S. Björnsson   +5 more
doaj   +1 more source

Genetic and Molecular Factors in Drug-Induced Liver Injury: A Review [PDF]

, 2007
The diagnosis of drug-induced liver injury (DILI) is challenging and based on complex diagnostic criteria. DILI falls into two main categories i) intrinsic 'dose-dependent' Type A reactions ii) 'idiosyncratic' or Type B reactions (which are usually not ...
Andrade, RJ, Carvajal, A, Cueto, R, Isabel Lucena, M, Molokhia, M, Pachkoria, K, Serrano Carballo, A   +6 more
core   +3 more sources