Results 111 to 120 of about 12,590 (214)

Drug-Induced Liver Injury (DILI): A Major Challenge [PDF]

Drug Research, 2021
openaire   +2 more sources

Microengineering the Liver: Strategies for Constructing Functional Liver‐on‐a‐Chip Devices

Exploration, Volume 6, Issue 2, April 2026.
This review summarizes recent advances in liver‐on‐a‐chip (LOC) technologies, including fabrication strategies and functional integration approaches, and discusses their promising applications in drug screening and related biomedical fields. ABSTRACT Reliable in vitro liver models are indispensable for researching liver diseases and developing ...
Jie Wang, Ziwei Liang, Jiapu Wang, Zongyi Li, Shaojie Wang, Yan Wei, Xin Xie, Di Huang   +7 more
wiley   +1 more source

Efek Pemberian Metilprednisolon Oral Terhadap Gambaran Histopatologik Hati Tikus Wistar (Rattus Norvegicus) [PDF]

, 2016
: Drug-induced liver injury (DILI) is an adverse drug reaction which vary in its clinical manifestations, ranging from an asymptomatic increase in liver enzymes to fulminant hepatic failure.
Durry, M. F. (Meilany), Lintong, P. M. (Poppy), Rifaldi, M. (Muhammad)   +2 more
core  

Characterization of amoxicillin‐ and clavulanic acid‐specific T cells in patients with amoxicillin‐clavulanate–induced liver injury [PDF]

, 2015
Drug‐induced liver injury (DILI) frequently has a delayed onset with several human leukocyte antigen (HLA) genotypes affecting susceptibility, indicating a potential role for the adaptive immune system in the disease.
Abajo, Bomarrito, Britschgi, Cavani, Daly, Danan, Donaldson, Fontana, Jenkins, Kindmark, Li, Lucena, Lucena, Maria, Mauri-Hellweg, Metushi, Monshi, Mudnakudu Nagaraju, Naisbitt, Nattrass, O'Donohue, Pichler, Pichler, Sabat, Schaid, Singer, Spraggs, Stephens, Wu, Wu, Wuillemin, Wuillemin, Yanaba, Yanaba   +33 more
core   +1 more source

Hepatotoxicity Associated with Labetalol Use: A Case Report with Systematic Review and Disproportionality Analysis Using FAERS

The Journal of Clinical Pharmacology, Volume 66, Issue 4, April 2026.
Abstract Labetalol is widely prescribed as a first‐line antihypertensive in pregnancy; however, rare but potentially severe idiosyncratic hepatotoxicity has been reported, with a disproportionately strong reporting signal for liver injury relative to other β‐blockers.
Emma D. Hendriksen, Michael Rieder, Elizabeth Urbantke   +2 more
wiley   +1 more source

Drug-induced liver injuries (Part 1)

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2012
The aim of review. To present modern concepts on mechanisms of drug-induced liver injury (DILI), to give their classification, to present approaches to disease diagnostics.Original positions.
S. F. Galimova
doaj  

Mechanistic insights into antiretroviral drug‐induced liver injury

Pharmacology Research & Perspectives, 2020
All classes of antiretroviral therapy (ART) have been implicated to induce adverse drug reactions such drug‐induced liver injury (DILI) and immune‐mediated adverse reactions in Human Immunodeficiency Virus (HIV) infected individuals.
Jamie N. Pillaye, Mohlopheni J. Marakalala, Nonhlanhla Khumalo, Wendy Spearman, Hlumani Ndlovu   +4 more
doaj   +1 more source

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease [PDF]

, 2016
Liver biology and function, drug-induced liver injury (DILI) and liver diseases are difficult to study using current in vitro models such as primary human hepatocyte (PHH) monolayer cultures, as their rapid de-differentiation restricts their usefulness ...
Bell, Catherine C, Dankers, Anita CA, Ellis, Ewa, Fredriksson Puigvert, Lisa, Goldring, Christopher EP, Hendriks, Delilah FG, Ingelman-Sundberg, Magnus, Jacobs, Frank, Jenkins, Rosalind E, Kitteringham, Neil R, Lauschke, Volker M, Mkrtchian, Souren, Moro, Sabrina ML, Nordling, Åsa, Park, B Kevin, Renblom, Anna, Sison-Young, Rowena L, Snoeys, Jan, Walsh, Joanne   +18 more
core   +2 more sources

Drug‐induced cholestasis

Hepatology Communications, 2017
Cholestatic drug‐induced liver injury (DILI) can be a diagnostic challenge due to a large differential diagnosis, variability in clinical presentation, and lack of serologic biomarkers associated with this condition.
Vinay Sundaram, Einar S. Björnsson
doaj   +1 more source

Rivaroxaban-induced hepatotoxicity: review of the literature and report of new cases [PDF]

, 2018
Aim/Objective/Background Direct-acting oral anticoagulant drugs are marketed worldwide for the primary and secondary prevention and treatment of thromboembolic disorders.
Almasio, Pier Luigi, Giannitrapani, Lydia, Licata, Anna, Lombardo, Vania, Minissale, Maria G, Montalto, Giuseppe, Morreale, Ilaria, Puccia, Fania, Serruto, Antonietta, Soresi, Maurizio   +9 more
core   +1 more source