Results 111 to 120 of about 6,710,280 (212)

The role of endoplasmic reticulum aminopeptidase ERAP2 pathogenic mutation rs1363907 in amoxicillin clavulanate-induced liver injury: a special case report

Frontiers in Pharmacology
Idiosyncratic hepatotoxicity is a type of drug-induced liver injury (DILI) that is unpredictable and clinically severe, and amoxicillin clavulanate (AC) is the most implicated drug in DILI worldwide. The clinical manifestations of amoxicillin clavulanate-
Yan Zhan, Yan Zhan, Yan Zhan, Yan Zhan, Jin-Mao Liao, Ling Ye, Ling Ye, Ling Ye, Ling Ye, Long Zhang, Long Zhang, Long Zhang, Long Zhang, Long Zhang, Zheng Zhang, Ji-Ye Yin, Ji-Ye Yin, Ji-Ye Yin, Ji-Ye Yin   +18 more
doaj   +1 more source

Diethylene Glycol‐Linked Ring‐Fused Bis‐Azoles: Target‐Oriented Synthesis, In Silico Screening, and Antitumor Activity

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A series of diethylene glycol‐linked cyclic derivatives with diversity in the heterocyclic motif have been synthesized and screened for antitumor activity. Two bis‐thiazolo[3,2‐a]pyrimidinone derivatives displayed moderate cytotoxicity, high selectivity against hepatocellular carcinoma cells, promising VEGFR2, and remarkable FGFR2 inhibitory activities
Sami A. Al‐Hussain, Abdulrahman S. Alharbi, Zeinab A. Muhammad, Alyaa S. Abdel Halim, Magdi E. A. Zaki, Mark C. Bagley, Refaie M. Kassab   +6 more
wiley   +1 more source

Drug‐Induced Liver Injury in Patients With Chronic Liver Disease

Objective: Drug-induced liver injury (DILI) is a global problem and can develop from exposure to prescription or over-the-counter medications as well as herbal and dietary supplements. The diagnosis of DILI is clinically challenging, and liver injury can
Ghabril, Marwan, Vuppalanchi, Raj, Chalasani, Naga   +2 more
core   +1 more source

Antibiotics and Drug Induced Liver Injury

, 2023
Drug-induced liver injury (DILI) is hepatotoxicity caused by therapeutic drugs or other noninfectious toxins. Antibiotics are etiologically the most common causes of DILI, so they are the main focus of this thesis. The aim of this thesis is to review the
Kore, Vaishnavee Umesh
core  

DRUG-INDUCED LIVER INJURY-DILI AND HILI IN CLINICAL PRACTICE

Drug-induced liver damage is still a problem for modern medicine. On the one hand, it is related tothe polyprogression found mainly in the elderly and chronically ill, and on the other hand, to thefashion for young people to use dietary supplements and herbs. The course of DILI can range froma mild, asymptomatic, reversible increase in liver parameters
Rajewski, Paweł, Jakub, Cieściński, Piotr, Rajewski   +2 more
openaire   +1 more source

Rapid‐Onset Drug‐Induced Liver Injury Following Amoxicillin‐Clavulanate: A Case Report

Clinical Case Reports
Drug‐Induced Liver Injury (DILI) is a rare but potentially serious adverse effect of many commonly used medications. DILI is a diagnosis of exclusion and requires a high index of suspicion.
Shuvam Khadka, Abinash Dev, Pramodman Singh Yadav, Sujan Acharya, Amisha Karki, Leeza Shah   +5 more
doaj   +1 more source

Research progress of mitochondrial dysfunction in drug-induced liver injury [PDF]

Yixue xinzhi zazhi
Drug-induced liver injury (DILI) is a type of drug-induced liver injury with complex and diverse mechanisms that can lead to liver failure in severe cases, thereby affecting patients' quality of life and survival.
SUN Huijuan, HU Wenkai, LIU Shumin
doaj   +1 more source

The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1. [PDF]

, 2014
BACKGROUND AND OBJECTIVE: Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1 ...
Ma, Jinfeng, Xuemei Yao, Mingqin Cao, Merle Corinne, Xia Zhu, Liu Wei, Weidong Wu, Yongguang Li, Jiayi Gu, Ma Jinfeng, Qian Wang, Milligan Paul, Zhu, Xia, Ying Mao, Liu, Wei, Ma Long, Jinfeng Ma, Xiang, Yang, Cao, Mingqin, Ma, Long, Merle, Corinne, Long Ma, Yang Lei, Xiang Yang, Yao Xuemei, Wubuli, Atikaimu, Wu, Weidong, Xin Xiumei, Li, Yongguang, Yang Xiang, Paul Milligan, Xiumei Xin, Lei Yang, Corinne Merle, Zhu Xia, Li Yongguang, Mao Ying, Milligan, Paul, Mao, Ying, Gu, Jiayi, Atikaimu Wubuli, Gu Jiayi, Yao, Xuemei, Wu Weidong, Wang Qian, Yang, Lei, Xin, Xiumei, Wang, Qian, Cao Mingqin, Wubuli Atikaimu, Wei Liu   +50 more
core   +1 more source

Duloxetine hepatotoxicity: a case-series from the drug-induced liver injury network [PDF]

, 2010
Aliment Pharmacol Ther 2010; 32: 1174–1183Case reports suggest that duloxetine hepatotoxicity may arise, but risk factors, presenting features and clinical course are not well-described.To describe the presenting features and outcomes of seven well ...
N. Chalasani, Fontana, Robert J., Chalasani, Naga, R. J. Fontana, Saxena, Romil, Bonkovsky, Herbert L., R. Saxena, Fontana, Robert John, The Drug Induced Liver Injury Network (DILIN), Hayashi, Paul H., Kleiner, D., H. Bonkovsky, Vuppalanchi, R., P. H. Hayashi, Bonkovsky, Herbert, J. H. Hoofnagle, D. Kleiner, Hoofnagle, Jay H., null null, Vuppalanchi, Raj, Hayashi, Paul, Kleiner, David, R. Vuppalanchi, Saxena, R.   +23 more
core   +1 more source

Genetic and Immune Predictors for Hypersensitivity Syndrome to Antiepileptic Drugs [PDF]

, 2011
Hypersensitivity syndrome reactions (HSR) to antiepileptic drugs (AED) are associated with severe clinical cutaneous adverse reactions (SCAR).Our aims are: to assess HSRs to AEDs using the in vitro lymphocyte toxicity assay (LTA) in patients who ...
Lawrence Cohen, Paul A. Hwang, Manuela G. Neuman, Radu M. Nanau   +3 more
core