Results 91 to 100 of about 12,590 (214)

Subtoxic Concentrations of Hepatotoxic Drugs Lead to Kupffer Cell Activation in a Human In Vitro Liver Model [PDF]

, 2015
Drug induced liver injury (DILI) is an idiosyncratic adverse drug reaction leading to severe liver damage. Kupffer cells (KC) sense hepatic tissue stress/damage and therefore could be a tool for the estimation of consequent effects associated with DILI ...
Burkhardt, Britta, Damm, Georg, Kegel, Victoria, Liu, Jia L., Nüssler, Andreas K., Pfeiffer, Elisa, Seehofer, Daniel, Zeilinger, Katrin   +7 more
core   +4 more sources

The rediscovery of HepG2 cells for prediction of drug induced liver injury (DILI)

EXCLI journal, 2014
EXCLI Journal ; Vol.
openaire   +3 more sources

Induction of Clinical Operational Tolerance Through Immunosuppression Minimization: Less Is More?

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT The goal of achieving clinical operational tolerance in liver transplantation has sparked significant interest, driven by the desire to mitigate the long‐term adverse effects of immunosuppression. Advances in understanding the immunological mechanisms underpinning operational tolerance in liver transplantation have highlighted the central role
Emilia Knioła, Bartosz Foroncewicz, Jan Lerut, Leszek Pączek, Krzysztof Mucha   +4 more
wiley   +1 more source

Drug induced liver injury in HIV patients on dolutegravir based antiretroviral therapy regimens in Wolaita Sodo comprehensive specialized hospital

Scientific Reports
Drug induced liver injury is the most common and life-threatening condition associated with antiretroviral therapy. Dolutegravir (DTG) based combination antiretroviral therapy (ART) is currently first line treatment for HIV infected patients in Ethiopia.
Firew Abraham, Alemayehu Toma, Tamrat Balcha, Bereket Molla Tigabu   +3 more
doaj   +1 more source

Serum proteomic profiling in patients with drug‐induced liver injury [PDF]

, 2012
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90324/1/apt4982 ...
Abboud, Amacher, Andersson, Au, Bell, Bjornsson, Bolstad, Bonkovsky, Bradford, Chalasani, Chalasani, Craig, Craig, Cui, Ellinger-Ziegelbauer, Eng, Ferre, Fontana, Hale, Higgs, Higgs, Jia, Kienhuis, Kleno, Laverty, Lewis, Maniratanachote, Merrick, Navarro, O'Connell, Orman, Ostapowicz, Reuben, Rockey, Rodriguez-Ariza, Scott, Shimada, Tujios, Vuppalanchi, Wang, Wang, Watkins, Welch   +42 more
core   +3 more sources

Relative Exchangeable and Exchangeable Copper: Emerging New Biomarkers for Diagnosis and Therapy Monitoring in Wilson's Disease

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT Background and Aims Wilson's disease (WD) is a genetic disorder of copper metabolism in which early diagnosis remains challenging, particularly in acute liver failure (ALF). Relative exchangeable copper (REC) and exchangeable copper (CuEXC) are emerging biomarkers for diagnosis and monitoring, but data from larger cohorts are limited.
Sebastian Köhrer, Antoan Rusev, Holger Zimmer, Silke Wolf, Jessica Langel, Andrea Langel, Thomas Longerich, Patrick Michl, Moritz Niesert, Alexander Fichtner, Isabelle Mohr   +10 more
wiley   +1 more source

Risk of acute and serious liver injury associated to nimesulide and other NSAIDs: data from drug-induced liver injury case-control study in Italy [PDF]

, 2016
Aim: Drug-induced liver injury is one of the most serious adverse drug reactions and the most frequent reason for restriction of indications or withdrawal of drugs. Some nonsteroidal anti-inflammatory drugs (NSAIDs) were withdrawn from the market because
Arzenton, E., Bonaiuti, R., Bortolami, O., Capuano, A., Conforti, A., Donati, M., Lenti, M.C., Leone, R., Moretti, U., Motola, D., Rafaniello, C., Sportiello, L., Vaccheri, A., Vannacci, A.   +13 more
core   +2 more sources

HLA‐B*44 Alleles and HLA‐DQA1*03:01 as Genetic Risk Factors for Drug‐Induced Liver Injury due to Fluoroquinolones

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT Background and Aims Fluoroquinolone exposure can give rise to drug‐induced liver injury. Genetic risk factors for this form of liver injury are poorly understood but some evidence suggests that HLA genes contribute. This study aimed to characterise HLA risk factors for fluoroquinolone‐induced liver injury in a European population. Methods From
Paola Nicoletti, M. Isabel Lucena, Raul J. Andrade, Samreen Zafer, Einar S. Bjornsson, Pär Hallberg, Dominique Larrey, Mariam Molokhia, Mia Wadelius, Guruprasad P. Aithal, Ann K. Daly   +10 more
wiley   +1 more source

Genetic and Immune Predictors for Hypersensitivity Syndrome to Antiepileptic Drugs [PDF]

, 2011
Hypersensitivity syndrome reactions (HSR) to antiepileptic drugs (AED) are associated with severe clinical cutaneous adverse reactions (SCAR).Our aims are: to assess HSRs to AEDs using the in vitro lymphocyte toxicity assay (LTA) in patients who ...
Lawrence Cohen, Manuela G. Neuman, Paul A. Hwang, Radu M. Nanau   +3 more
core   +1 more source

Natural history and outcomes in drug induced autoimmune hepatitis [PDF]

, 2016
Aim: Drug-induced autoimmune hepatitis (DIAIH) remains poorly characterized. Our aim was to assess natural history and outcomes in DIAIH. Methods: This was a retrospective cohort study.
Alla, Alvarez, Andrade, Appleyard, Björnsson, Björnsson, Björnsson, Castiella, Castiella, Cohen, Danan, Feld, Heneghan, Heurgué, Kennedy, Kocman, Lawrenson, Licata, Lucena, MacGregor, Manns, Navarro, Roberts, Russo, Sakaan, Scully, Sharp, Shepherd, Sugimoto, Suzuki, Unzueta, Verma, Verma, Weiler-Normann   +33 more
core   +1 more source