Results 131 to 140 of about 6,710,280 (212)

Exploring drug-induced liver injury: comprehensive insights into mechanisms and management of hepatotoxic agents

Future Journal of Pharmaceutical Sciences
Background Drug-induced liver injury (DILI) is a significant adverse drug reaction, manifesting through a range of clinical presentations from mild liver enzyme to acute liver failure.
Ahmed K. Saleh, Thanaa A. El-Masry, Aya H. El-Kadem, Nada A. Ashour, Nageh A. El-Mahdy   +4 more
doaj   +1 more source

EGCG inhibits ferroptosis to ameliorate APAP-induced liver injury by suppressing NEDD8 and stabilizing HUWE1 in vivo and in vitro

Acta Materia Medica
Excessive consumption of acetaminophen (APAP) has emerged as the primary culprit behind drug-induced liver injury (DILI), with N-acetylcysteine serving as the principal antidote.
Zijun Ouyang, Tao Zhang, Mengting Liu, Fufu Li, Hui Guo, Yanhui Li, Jieyu Chen, Feiyang Wang, Yang Sun, Dong Liu, Haiyan Sun   +10 more
doaj   +1 more source

HLA-B*53:01 is a significant risk factor for liver injury due to phenytoin and other anti-epileptic drugs in African Americans

Introduction: To investigate human leukocyte antigen alleles associated with liver injury due to antiepileptic drugs (AEDs) in African Americans (AA). Methods: In this study, 21 AA with AED drug-induced liver injury (DILI), 176 AA with DILI due to non ...
Phillips, Elizabeth, Dellinger, Andrew, Chalasani, Naga, Li, Yi-Ju, Barnhart, Huiman, Drug Induced Liver Injury Network (DILIN) investigators, Nicoletti, Paola   +6 more
core   +1 more source

Clinical and Genetic Associations in Cephalosporin-Induced Liver Injury: Insights From the Drug-Induced Liver Injury Network [PDF]

Introduction: Cephalosporins are widely prescribed antibiotics due to their efficacy and safety. Although rare, idiosyncratic drug-induced liver injury (DILI) has been reported with their use.
Drug-Induced Liver Injury Network (DILIN), Vuppalanchi, Raj, Halegoua-DeMarzio, Dina, Fontana, Robert J., Hoofnagle, Jay H., Li, Yi-Ju, Bonkovsky, Herbert L., Koh, Christopher, Barnhart, Huiman, Rockey, Don C., Odin, Joseph   +10 more
core   +1 more source

Guideline review: EASL clinical practice guidelines: drug-induced liver injury (DILI). [PDF]

Frontline Gastroenterol, 2022
Brennan PN, Cartlidge P, Manship T, Dillon JF.   +3 more
europepmc   +1 more source

Hepatotoxicity associated with statins: A retrospective pharmacovigilance study based on the FAERS database.

PLoS ONE
BackgroundStatins are commonly prescribed in clinical practice and are associated with a high risk of drug-induced liver injury (DILI). This study aims to examine the real-world data on statin-induced liver injury to assess medication safety.MethodsAll ...
Lu Zhou, Bin Wu, Yuan Bian, Yun Lu, Ya Zou, Shanshan Lin, Qinchuan Li, Chun Liu   +7 more
doaj   +1 more source

Mechanisms and research progress of the association between lipid metabolism disorders and drug-induced liver injury

Neike lilun yu shijian
Drug-induced liver injury (DILI) is a common and highly heterogeneous adverse drug reaction in clinical practice. Drug-induced fatty liver disease (DIFLD) is a distinct subtype of DILI characterized primarily by abnormal hepatic lipid accumulation ...
Rongtao LAI, Weiqian LOU
doaj   +1 more source

Drug Induced Liver Injury (DILI): a short review

Istanbul Journal of Pharmacy, 2017
Muzeyyen Celikoz, Buket Hun, Gul Ozhan
openaire   +2 more sources

Deriving time-concordant event cascades from gene expression data: A case study for Drug-Induced Liver Injury (DILI). [PDF]

PLoS Comput Biol, 2022
Liu A, Han N, Munoz-Muriedas J, Bender A.   +3 more
europepmc   +1 more source

Anticancer Drug-induced Liver Injury

With the recent advances in the field of medical oncology and the development of new exciting domain of immunotherapy, the longevity of patients with various cancers has increased.
Kaushal Madan, Akash Goel
core   +1 more source