Results 121 to 130 of about 12,590 (214)

Role of Gut Microecology in the Pathogenesis of Drug-Induced Liver Injury and Emerging Therapeutic Strategies

Molecules
Drug-induced liver injury (DILI) is a common clinical pharmacogenic disease. In the United States and Europe, DILI is the most common cause of acute liver failure.
Yuqiao Huang, Yu Zhang, Kaireng Wu, Xinxin Tan, Tian Lan, Guixiang Wang   +5 more
doaj   +1 more source

Systems Toxicology Approach to Identifying Paracetamol Overdose [PDF]

, 2018
Paracetamol (acetaminophen (APAP)) is one of the most commonly used analgesics in the United Kingdom and the United States. However, exceeding the maximum recommended dose can cause serious liver injury and even death.
Ambrosius, Antoine, Antoine, Antoine, Antoine, Antoine, Bateman, Bateman, Bechmann, Beger, Ben-Shachar, Bewick, Brillant, Chiew, Clarke, Coen, Dear, Diaz Ochoa, Giannini, Hinson, Jaeschke, Juurlink, Larson, Lea, Longo, Maaten, Metzler, Reddyhoff, Reith, Remien, Remien, Rumack, Sharma, Shoda, Williams   +34 more
core   +4 more sources

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man [PDF]

, 2016
The current test systems employed by pharmaceutical industry are poorly predictive for drug-induced liver injury (DILI). The ‘MIP-DILI’ project addresses this situation by the development of innovative preclinical test systems which are both mechanism ...
Dragovic, Sanja, Gerets, Helga H, Hewitt, Philip G, Ingelman-Sundberg, Magnus, Juhila, Satu, Park, B Kevin, Snoeys, Jan, Vermeulen, Nico PE, Weaver, Richard J   +8 more
core   +1 more source

The role of endoplasmic reticulum aminopeptidase ERAP2 pathogenic mutation rs1363907 in amoxicillin clavulanate-induced liver injury: a special case report

Frontiers in Pharmacology
Idiosyncratic hepatotoxicity is a type of drug-induced liver injury (DILI) that is unpredictable and clinically severe, and amoxicillin clavulanate (AC) is the most implicated drug in DILI worldwide. The clinical manifestations of amoxicillin clavulanate-
Yan Zhan, Yan Zhan, Yan Zhan, Yan Zhan, Jin-Mao Liao, Ling Ye, Ling Ye, Ling Ye, Ling Ye, Long Zhang, Long Zhang, Long Zhang, Long Zhang, Long Zhang, Zheng Zhang, Ji-Ye Yin, Ji-Ye Yin, Ji-Ye Yin, Ji-Ye Yin   +18 more
doaj   +1 more source

Research progress of mitochondrial dysfunction in drug-induced liver injury [PDF]

Yixue xinzhi zazhi
Drug-induced liver injury (DILI) is a type of drug-induced liver injury with complex and diverse mechanisms that can lead to liver failure in severe cases, thereby affecting patients' quality of life and survival.
SUN Huijuan, HU Wenkai, LIU Shumin
doaj   +1 more source

Rapid‐Onset Drug‐Induced Liver Injury Following Amoxicillin‐Clavulanate: A Case Report

Clinical Case Reports
Drug‐Induced Liver Injury (DILI) is a rare but potentially serious adverse effect of many commonly used medications. DILI is a diagnosis of exclusion and requires a high index of suspicion.
Shuvam Khadka, Abinash Dev, Pramodman Singh Yadav, Sujan Acharya, Amisha Karki, Leeza Shah   +5 more
doaj   +1 more source

Albendazole-induced granulomatous hepatitis: a case report [PDF]

, 2013
INTRODUCTION: Drug-related hepatotoxicity is a common medical problem with implications for health systems. It constitutes a cause of acute liver failure and, in many cases, is responsible for the rejection of new pharmacological agents during efficacy ...
Andres Eduardo Marin Castro, Juan Camilo Perez Cadavid, Juan Carlos Restrepo Gutierrez, Juan Ignacio Marin Zuluaga   +3 more
core   +1 more source

Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action [PDF]

, 2014
Summary The Human Toxicology Project Consortium (HTPC) was created to accelerate implementation of the science and policies required to achieve a pathway-based foundation for toxicology as articulated in the 2007 National Research Council report on ...
ANDERSEN Melvin E., AVIGAN Mark, CAVERLY RAE Jessica, DUCHÉ Daniel, GOYAK Katy, HARTUNG T., JAESCHKE Hartmut, KLEENSANG Andre, LANDESMANN Brigitte, MINSAVAGE Gary, ROWAN Andrew, SCHULTZ Terry, SEED Jennifer, SENIOR John, SHAH Imran, SUBRAMANIAN Kas, TOOLE Colleen, VINKEN Mathieu, WATKINS Paul, WESTMORELAND Carl, WILLETT Catherine   +20 more
core   +1 more source

Drug-induced liver injury. Part I: Classification, diagnosis and treatment

Clinical & Experimental Hepatology
Drug-induced liver injury (DILI) is a growing clinical problem. Antibiotics remain the most common cause of DILI in Europe. Their clinical spectrum is very broad, from asymptomatic to acute liver failure. Currently, DILI is categorized as hepatocellular (
Dorota M. Kozielewicz, Piotr Stalke, Julita Skrzypek   +2 more
doaj   +1 more source

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity. [PDF]

, 2017
Assessing the potential of a new drug to cause drug-induced liver injury (DILI) is a challenge for the pharmaceutical industry. We therefore determined whether cell models currently used in safety assessment (HepG2, HepaRG, Upcyte and primary human ...
Aerts, H, Alexandre, E, Antherieu, S, Dorau, M, Elmasry, M, Gerets, HHJ, Goldring, CE, Hewitt, PG, Holder, JC, Hoët, D, Ingelman-Sundberg, M, Johann, E, Jones, RP, Kitteringham, NR, Labbe, G, Lauschke, VM, Lovatt, CA, Park, BK, Richert, L, Schofield, CA, Sison-Young, RL, Stahl, SH, Weaver, RJ   +22 more
core   +1 more source