Results 51 to 60 of about 12,201 (250)

Computational Approaches for Drug-Induced Liver Injury (DILI) Prediction: State of the Art and Challenges [PDF]

, 2021
Drug-induced liver injury (DILI) is one of the prevailing causes of fulminant hepatic failure. It is estimated that three idiosyncratic drug reactions out of four result in liver transplantation or death. Additionally, DILI is the most common reason for withdrawal of an approved drug from the market.
Béquignon, O.J.M., Pawara, G., Water, B. van de, Cronin, M.T.D., Westen, G.J.P. van   +4 more
openaire   +2 more sources

Hepatocyte DDX3X protects against drug-induced acute liver injury via controlling stress granule formation and oxidative stress

Cell Death and Disease, 2023
Drug-induced liver injury (DILI) is the leading cause of acute liver failure (ALF). Continuous and prolonged hepatic cellular oxidative stress and liver inflammatory stimuli are key signatures of DILI.
Tingting Luo, Suzhen Yang, Tianming Zhao, Hanlong Zhu, Chunyan Chen, Xiaoxiao Shi, Di Chen, Kai Wang, Kang Jiang, Dan Xu, Ming Cheng, Juan Li, Wenting Li, Weijun Xu, Lin Zhou, Mingzuo Jiang, Bing Xu   +16 more
doaj   +1 more source

Diagnostics and outcome predictorso drug induced liver injury: a single center prospective study [PDF]

, 2022
Background: Although drug-induced liver injury (DILI) is a rare clinical event, it carries significant morbidity and mortality. The diagnostic approach of DILI is still challenging because of lack of reliable markers that would allow distinguishing DILI ...
Alhaddad, Omkolsoum M., Elsabaawy, Maha M., ElSharkawy, Amany S., Hendy, Olfat M., Mazaly, Mohamed A., Sabry, Aliaa A.   +5 more
core   +1 more source

Drug‐Induced Liver Injury in GI Practice

Hepatology Communications, 2020
Although drug‐induced liver injury (DILI) is a rare clinical event, it carries significant morbidity and mortality, leaving it as the leading cause of acute liver failure in the United States.
Naemat Sandhu, Victor Navarro
doaj   +1 more source

Stochastic Ordering under Conditional Modelling of Extreme Values: Drug-Induced Liver Injury [PDF]

, 2014
Drug-induced liver injury (DILI) is a major public health issue and of serious concern for the pharmaceutical industry. Early detection of signs of a drug's potential for DILI is vital for pharmaceutical companies' evaluation of new drugs.
Box, Coles, Coles, Cox, Davison, Eastoe, Food and Drug Administration, Genest, Heffernan, Hilal, Jameson, Joe, Keef, Keef, Koenker, Ledford, Nelsen, Papastathopoulos, Paulo, Schmid, Sibuya, Southworth, Southworth, Tiago de Oliveira, Yu, Zimmerman, Zimmerman   +26 more
core   +1 more source

Pharmacogenomics of drug-induced liver injury (DILI): Molecular biology to clinical applications [PDF]

Journal of Hepatology, 2018
A 21-year old woman was admitted to hospital with a two-week history of painless jaundice, fatigue and anorexia having previously been fit and well. One month prior to presentation, the patient had taken a five-day course of amoxicillin-clavulanic acid for an infected skin cyst.
William J.H. Griffiths, Jane I. Grove, Jane I. Grove, Guruprasad P. Aithal, Guruprasad P. Aithal, Adam Duckworth, Kalaiyarasi Kaliyaperumal, Robin M. Delahay, Robin M. Delahay   +8 more
openaire   +3 more sources

A Comprehensive Review on the Use of Herbal Dietary Supplements in the USA, Reasons for Their Use, and Review of Potential Hepatotoxicity

Livers, 2022
Herbal and dietary supplement (HDS) use has grown exponentially in the United States. Unfortunately, the incidence of HDS-related liver injury has proportionally increased.
Adnan Khan, Kashyap Chauhan, Heather Ross, Natalia Salinas Parra, John Magagna, Makala Wang, Patrick Zhu, Ryan Erwin, Dina Halegoua-DeMarzio   +8 more
doaj   +1 more source

The diagnosis and management of idiosyncratic drug‐induced liver injury [PDF]

, 2019
Drug‐induced liver injury (DILI) is an uncommon but important cause of liver disease that can arise after exposure to a multitude of drugs and herbal and dietary supplements.
Abenavoli, Aithal, Aithal, Aithal, Amacher, Andrade, Antoine, Antoine, Antoine, Avancini, Baniasadi, Begriche, Bernal, Bernal, Björnsson, Björnsson, Björnsson, Björnsson, Chalasani, Chalasani, Chalasani, Chomchai, Church, Church, Crance, Dakhoul, Daly, Danan, Danica, Dara, Day, de, Flora, Fontana, Fontana, Fontana, Forbes, Foureau, Foureau, Ghabril, Gu, Harrill, Hayashi, Hayashi, Heurgué, Hillman, Hoofnagle, Hu, Huffman, Hung, Katsinelos, Kindmark, Kleiner, Knowles, Koch, Koga, Larkin, Lee, Lee, Lee, Liou, Loomus, Manns, Medina-Caliz, Moreno, Mosedale, Nicoletti, O'Brien, Ohmori, Ostapowicz, Pisetsky, Reuben, Robles-Diaz, Rockey, Rutherford, Sato, Schröder, Senior, Sgro, Shah, Squires, Stine, Suk, Takikawa, Tani, Thulin, Tsokos, Urban, Van Boeckel, Van Erpecum, Villa, Wang, Weber, Wong, Zhang, Zhang, Zhou, Zimmerman   +97 more
core   +1 more source

Bismuth subcitrate, metronidazole and tetracycline – a rare cause of drug-induced liver injury

European Journal of Case Reports in Internal Medicine, 2023
Drug-induced liver injury (DILI) is a liver condition caused by any drug or toxic substance. The spectrum of DILI manifestations can range from asymptomatic elevation of liver enzymes to acute liver failure.
Carina Silva, Susana Merim, Rita Sevivas, João Mota, Alexandra Leitão   +4 more
doaj   +1 more source

Treatment of Idiosyncratic Drug-Induced Liver Injury Using Steroids [PDF]

, 2020
Idiosyncratic drug-induced liver injury (DILI), when severe, can be associated with significant morbidity and mortality. Currently, there are no specific therapies for DILI, apart from corticosteroids for drug-induced autoimmune hepatitis caused by drugs
Chalasani, Naga, Saxena, Romil, Sundaram, Suneha, Vuppalanchi, Raj   +3 more
core   +1 more source