Results 51 to 60 of about 11,641 (246)

Relationship Between Characteristics of Medications and Drug-Induced Liver Disease Phenotype and Outcome [PDF]

, 2014
Background & Aims: It is not known if specific characteristics of medication are associated with type of drug-induced liver injury (DILI) or outcome.
Chalasani, Naga, Fontana, Robert J., Ghabril, Marwan, Gotur, Raghavender, Gu, Jiezhun, Kosinski, Andrzej S., Reddy, K. Rajender, Serrano, Jose, Vuppalanchi, Raj   +8 more
core   +1 more source

Hepatic macrophages in drug-induced liver injury

Liver Research, 2019
Drug-induced liver injury (DILI) is a major public health concern. Intrinsic DILI, for example, acetaminophen overdose accounts for half of acute liver failure in the United States.
Zhao Shan, Cynthia Ju
doaj   +1 more source

An Overview on the Proposed Mechanisms of Antithyroid Drugs-Induced Liver Injury [PDF]

Advanced Pharmaceutical Bulletin, 2015
Drug-induced liver injury (DILI) is a major problem for pharmaceutical industry and drug development. Mechanisms of DILI are many and varied.
Reza Heidari, Hossein Niknahad, Akram Jamshidzadeh, Mohammad Ali Eghbal, Narges Abdoli   +4 more
doaj   +1 more source

Consensus: guidelines: best practices for detection, assessment and management of suspected acute drug-induced liver injury during clinical trials in patients with nonalcoholic steatohepatitis [PDF]

, 2019
BACKGROUND: The last decade has seen a rapid growth in the number of clinical trials enrolling patients with nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH).
Adams, Aithal, Andrade, Angulo, Armstrong, Arroyo, Athyros, Avigan, Banderas, Bays, Belfort, Bjornsson, Caldwell, Chalasani, Chalasani, Chalasani, Chalasani, Chalasani, Chalasani, Chalasani, Cusi, De Denus, De Santis, Dutta, Eijgenraam, Ekstedt, Ekstedt, European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD), European Association for the Study of Obesity (EASO), Fontana, Friedman, Friedman, Giannini, Guha, Hayashi, Hoofnagle, Hyysalo, Im, Jalan, Kaplan, Kleiner, Kleiner, Kolwankar, Kowdley, Kullak-Ublick, Kwok, LaBrecque, Lavine, Lewis, Lewis, Liddle, Lo Re, Loomba, Maurice, McPherson, Moylan, Mudaliar, Neuschwander-Tetri, Panteghini, Pantsari, Patel, Patel, Pfeffer, Ratziu, Ratziu, Regev, Reid, Robles-Diaz, Rockstroh, Russo, Sanyal, Sanyal, Sanyal, Scorletti, Senior, Siddiqui, Stefan, Tarantino, Temple, Valenti, Verna, Vilar-Gomez, Vuppalanchi, Vuppalanchi, Vuppalanchi, Watkins, Weltman, Wong, Younossi, Younossi, Zelber-Sagi, Zhou, Zimmerman   +91 more
core   +1 more source

Pregnane X receptor in drug-induced liver injury: Friend or foe?

Liver Research, 2018
The pregnane X receptor (PXR) is a ligand activated nuclear receptor that is highly expressed in the liver and regulates many cellular functions including drug metabolism, endobiotic metabolism, oxidative stress response, apoptosis, inflammation, cell ...
Amina I. Shehu, Xiaochao Ma
doaj   +1 more source

Hepatocyte DDX3X protects against drug-induced acute liver injury via controlling stress granule formation and oxidative stress

Cell Death and Disease, 2023
Drug-induced liver injury (DILI) is the leading cause of acute liver failure (ALF). Continuous and prolonged hepatic cellular oxidative stress and liver inflammatory stimuli are key signatures of DILI.
Tingting Luo, Suzhen Yang, Tianming Zhao, Hanlong Zhu, Chunyan Chen, Xiaoxiao Shi, Di Chen, Kai Wang, Kang Jiang, Dan Xu, Ming Cheng, Juan Li, Wenting Li, Weijun Xu, Lin Zhou, Mingzuo Jiang, Bing Xu   +16 more
doaj   +1 more source

Pharmacogenomics of drug-induced liver injury (DILI): Molecular biology to clinical applications [PDF]

Journal of Hepatology, 2018
A 21-year old woman was admitted to hospital with a two-week history of painless jaundice, fatigue and anorexia having previously been fit and well. One month prior to presentation, the patient had taken a five-day course of amoxicillin-clavulanic acid for an infected skin cyst.
William J.H. Griffiths, Jane I. Grove, Jane I. Grove, Guruprasad P. Aithal, Guruprasad P. Aithal, Adam Duckworth, Kalaiyarasi Kaliyaperumal, Robin M. Delahay, Robin M. Delahay   +8 more
openaire   +3 more sources

Potential Effects of Dietary Isoflavones on Drug-Induced Liver Injury

Journal of Food Quality, 2021
Numerous prescribed drugs and herbal and dietary supplements have been reported to cause drug-induced acute liver injury, which is a frequent cause of acute liver failure (ALF).
Liangliang Yao, Muhammad Farrukh Nisar, Tingdong Yan, Chunpeng (Craig) Wan   +3 more
doaj   +1 more source

Insuficiência Hepática Aguda Induzida pela Trazodona e Diazepam [PDF]

, 2016
Most antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the
Barroso, E, Carvalhana, S, Ferreira, P, Oliveira, A, Perdigoto, R, Resende, M   +5 more
core   +1 more source

Hepatotoxicity by Drugs: The Most Common Implicated Agents. [PDF]

, 2016
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.Idiosyncratic drug-induced liver injury (DILI) is
Björnsson, Einar S
core   +2 more sources