Results 81 to 90 of about 12,091 (224)

A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury [PDF]

, 2019
BACKGROUND & AIMS: We performed genetic analyses of a multiethnic cohort of patients with idiosyncratic drug-induced liver injury (DILI) to identify variants associated with susceptibility.
Cirulli, Elizabeth T., Drug-Induced Liver Injury Network, Int DILI Consortium iDILIC, Laitinen, Tarja, Nicoletti, Paola   +4 more
core   +1 more source

Progress in the treatment of drug-induced liver injury with natural products

Pharmacological Research, 2022
There are numerous prescription drugs and non-prescription drugs that cause drug-induced liver injury (DILI), which is the main cause of liver disease in humans around the globe. Its mechanism becomes clearer as the disease is studied further.
Yuan-kai Sun, Ya-fei Zhang, Li Xie, Fan Rong, Xing-yu Zhu, Jing Xie, Huan Zhou, Tao Xu   +7 more
doaj   +1 more source

Bacterial Extracellular Vesicles in the Pathogenesis and Treatment of Liver Diseases

Journal of Gastroenterology and Hepatology, EarlyView.
Liver diseases are a major global health challenge, with current treatments inadequate. This review highlights the role of bacterial extracellular vesicles in liver inflammation, fibrosis, and metabolism. We also explore these from commensals and probiotics, their protective effects, and discuss research challenges and future therapeutic potential ...
Yakun Li, Jia Li, Robin P. F. Dullaart, Han Moshage   +3 more
wiley   +1 more source

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity. [PDF]

, 2017
Assessing the potential of a new drug to cause drug-induced liver injury (DILI) is a challenge for the pharmaceutical industry. We therefore determined whether cell models currently used in safety assessment (HepG2, HepaRG, Upcyte and primary human ...
Aerts, H, Alexandre, E, Antherieu, S, Dorau, M, Elmasry, M, Gerets, HHJ, Goldring, CE, Hewitt, PG, Holder, JC, Hoët, D, Ingelman-Sundberg, M, Johann, E, Jones, RP, Kitteringham, NR, Labbe, G, Lauschke, VM, Lovatt, CA, Park, BK, Richert, L, Schofield, CA, Sison-Young, RL, Stahl, SH, Weaver, RJ   +22 more
core   +1 more source

Drug-induced liver injury: A primer for cardiologists

Journal of Clinical and Preventive Cardiology, 2022
Although drug-induced liver injury (DILI) is an uncommon diagnosis, it is an important cause of morbidity and mortality in hepatology practice. A timely diagnosis of DILI is important to stop causative drugs and keeping a high index of suspicion is ...
Narendra Singh Choudhary, Neeraj Saraf, Vinod Kumar, Manish Bansal, Ravi R Kasliwal   +4 more
doaj   +1 more source

Comparison of Two Artificial Liver Treatments for Acute Liver Failure: A Retrospective Observational Study

Nursing in Critical Care, Volume 31, Issue 2, March 2026.
ABSTRACT Background Liver failure can lead to severe disorders in the body's metabolism, detoxification, synthesis and other functions, with a high mortality rate of 60%–90%. The dual plasma molecular adsorption system (DPMAS) is a new artificial liver technology that has received much attention in recent years.
Xiulian Wu, Dongxia Wu, Xiaoqing Sun, Wenhui Wang, Jiayuan Wei, Xin Liu, Yanmei Gu   +6 more
wiley   +1 more source

A case report of vanishing bile duct syndrome after exposure to pexidartinib (PLX3397) and paclitaxel. [PDF]

, 2019
Pexidartinib (PLX3397) is a small molecule tyrosine kinase and colony-stimulating factor-1 inhibitor with FDA breakthrough therapy designation for tenosynovial giant-cell tumor, and currently under study in several other tumor types, including breast ...
Chien, A Jo, Esserman, Laura J, Hyland, Colby, Piawah, Sorbarikor, Rugo, Hope S, Umetsu, Sarah E   +5 more
core  

Comparative analysis of portal hepatic infiltrating leucocytes in acute drug‐induced liver injury, idiopathic autoimmune and viral hepatitis [PDF]

, 2015
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110851/1/cei12558 ...
Bahjat, Bonkovsky, Chalasani, Cheever, Chitturi, deLemos, Doherty, Fontana, Fontana, Holt, Ishak, Jaeschke, Jost, Kaplowitz, Kelly, Kelly, Kleiner, Kleiner, Kurachi, McFarlane, Michael, Navarro, Novobrantseva, Rockey, Rubio, Suzuki, Vogel, Washington, Wasley, Winwood   +29 more
core   +1 more source

Drug induced liver injury in HIV patients on dolutegravir based antiretroviral therapy regimens in Wolaita Sodo comprehensive specialized hospital

Scientific Reports
Drug induced liver injury is the most common and life-threatening condition associated with antiretroviral therapy. Dolutegravir (DTG) based combination antiretroviral therapy (ART) is currently first line treatment for HIV infected patients in Ethiopia.
Firew Abraham, Alemayehu Toma, Tamrat Balcha, Bereket Molla Tigabu   +3 more
doaj   +1 more source

Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation

Advanced Science, Volume 13, Issue 9, 13 February 2026.
Photoacoustic microscopy (PAM) is a powerful biomedical imaging tool renowned for its non‐invasiveness and high resolution. This review synthesizes recent technological advances and highlights their broad applications from cellular and organ‐level to whole‐animal imaging.
Tingting Wang, Jiali Chen, Liming Nie, Honghui Li   +3 more
wiley   +1 more source