Results 81 to 90 of about 12,201 (250)

Utility of Liver Biopsy in the Diagnosis and Management of Possible Drug-Induced Liver Injury in Patients Receiving Antituberculosis Therapy: A Retrospective Study

Infectious Disease Reports, 2023
Background: Drug-induced liver injury (DILI) secondary to ATT treatment (TB-DILI) is reported in 2–28% of patients. We present here a series of clinical cases of suspected DILI arising during antituberculosis treatment, studied with the aid of liver ...
Gina Gualano, Drieda Zace, Silvia Mosti, Paola Mencarini, Maria Musso, Raffaella Libertone, Carlotta Cerva, Delia Goletti, Alessia Rianda, Franca Del Nonno, Laura Falasca, Fabrizio Palmieri   +11 more
doaj   +1 more source

Establishment of a mouse model of enalapril-induced liver injury and investigation of the pathogenesis [PDF]

, 2017
Drug-induced liver injury (DILI) is a major concern in drug development and clinical drug therapy. Since the underlying mechanisms of DILI have not been fully understood in most cases, elucidation of the hepatotoxic mechanisms of drugs is expected ...
73756, 73757, 73758, 73759, 73760, Makino, Sayaka, Oda, Shingo, Shirai, Yuji, Tsuneyama, Koichi, Yokoi, Tsuyoshi   +9 more
core   +1 more source

Bacteroides fragilis 839 ameliorates anti-tuberculosis drugs-induced liver injury by suppressing inflammation and regulating gut microbiota in mice

Frontiers in Medicine
Anti-tuberculosis drug-induced liver injury (ATB-DILI), caused by first-line anti-tuberculosis (anti-TB) drugs, disrupts treatment and increases the risk of drug resistance.
Qiujuan Li, Chenbing Wu, Kangshuai Zhang, Ziyi Zhou, Jing Li, Jie Bai, Jun Cao, Xiaoxia Shi   +7 more
doaj   +1 more source

The Diagnosis and Manifestations of Liver Injury Secondary to Off-Label Androgenic Anabolic Steroid Use

Case Reports in Gastroenterology, 2016
Drug-induced liver injury (DILI) presents as a broad spectrum of adverse drug reactions which can range from a mild elevation in liver enzymes to fulminant liver failure.
Elena Cabb, Shanna Baltar, David Wes Powers, Karthik Mohan, Antonio Martinez, Eric Pitts   +5 more
doaj   +1 more source

Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

Advanced Science, EarlyView.
Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai, Lianlian Wu, Ruijiang Li, Yang Cao, Song He, Xiaochen Bo   +5 more
wiley   +1 more source

DILI: A Distribution-Driven Learned Index (Extended version) [PDF]

arXiv, 2023
Targeting in-memory one-dimensional search keys, we propose a novel DIstribution-driven Learned Index tree (DILI), where a concise and computation-efficient linear regression model is used for each node. An internal node's key range is equally divided by its child nodes such that a key search enjoys perfect model prediction accuracy to find the ...
arxiv  

Hepatotoxicity by Drugs: The Most Common Implicated Agents. [PDF]

, 2016
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.Idiosyncratic drug-induced liver injury (DILI) is
Björnsson, Einar S
core   +2 more sources

Processing‐induced reduction in dianthrones content and toxicity of Polygonum multiflorum: Insights from ultra‐high performance liquid chromatography triple quadrupole mass spectrometry analysis and toxicological assessment

Animal Models and Experimental Medicine, EarlyView.
In this study, we conducted measurements to determine the content of dianthrones in Polygoni Multiflori Radix (PMR) and Polygoni Multiflori Radix Praeparata (PMRP) samples from different stages of processing. Furthermore, we evaluated their hepatotoxicity using the human hepatocyte cell line L02 and Zebrafish embryos.
Wan‐Fang Li, Ying Wang, Cai‐Xia Qiu, Jie Li, Jie Bao, Jian‐Bo Yang, Hong‐Tao Jin   +6 more
wiley   +1 more source

Drug-induced liver injury: A primer for cardiologists

Journal of Clinical and Preventive Cardiology, 2022
Although drug-induced liver injury (DILI) is an uncommon diagnosis, it is an important cause of morbidity and mortality in hepatology practice. A timely diagnosis of DILI is important to stop causative drugs and keeping a high index of suspicion is ...
Narendra Singh Choudhary, Neeraj Saraf, Vinod Kumar, Manish Bansal, Ravi R Kasliwal   +4 more
doaj   +1 more source

Machine Learning Models to Predict Inhibition of the Bile Salt Export Pump [PDF]

arXiv, 2020
Drug-induced liver injury (DILI) is the most common cause of acute liver failure and a frequent reason for withdrawal of candidate drugs during preclinical and clinical testing. An important type of DILI is cholestatic liver injury, caused by buildup of bile salts within hepatocytes; it is frequently associated with inhibition of bile salt transporters,
arxiv