Results 81 to 90 of about 964 (152)

A Randomized Phase 1 Study Evaluating Pharmacokinetics, Safety, and Tolerability of a High‐Concentration, Long‐Acting Cabotegravir Formulation in Adults Without HIV

Clinical Pharmacology in Drug Development, Volume 14, Issue 7, Page 528-541, July 2025.
Abstract Long‐acting (LA) cabotegravir 200‐mg/mL (CAB200) injections are approved for HIV‐1 prevention and as a complete LA HIV‐1 treatment regimen with rilpivirine. A high‐concentration suspension formulation, cabotegravir 400 mg/mL (CAB400‐D), was developed to enable less frequent dosing and self‐administration. This phase 1, double‐blind, randomized
Kelong Han, Paul Benn, Jörg Sievers, David Dorey, Michael Warwick‐Sanders, Randa Hareedy, Louise Harkness, Claudia Leemereise, Kjersten Offenbecker, Christina Donatti, Darin B. Brimhall, Christian Schwabe, Craig Boyle, Michael A. Hassman, Steve Knowles, Ronald D'Amico, William R. Spreen   +16 more
wiley   +1 more source

Drug-induced liver injuries (Part 1)

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2012
The aim of review. To present modern concepts on mechanisms of drug-induced liver injury (DILI), to give their classification, to present approaches to disease diagnostics.Original positions.
S. F. Galimova
doaj  

Evaluation of Nutraceutical Potential of Carduus marianus: Antioxidant and Hepatoprotective Effects in Paracetamol‐Induced Hepatotoxicity and GC–MS Analysis

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
This study evaluates the hepatoprotective potential of Carduus marianus aqueous extract in male Wistar rats subjected to paracetamol‐induced hepatotoxicity. Paracetamol metabolism via hepatic cytochrome P450 enzymes generates NAPQI, triggering oxidative stress, inflammation, and vascular disturbances, culminating in hepatic necrosis. Pre‐treatment with
Mehreen Nasir, Faisal Gulzar, Sajida Jamil, Irfan Anjum, Abdul Malik, Suhail Akhtar, Nouman Ali   +6 more
wiley   +1 more source

A case report of a drug‐induced liver injury (DILI) caused by multiple antidepressants with causality established by the updated Roussel Uclaf causality assessment method (RUCAM) and in vitro testing [PDF]

, 2020
Miguel González‐Muñoz, Jaime Monserrat Villatoro, Eva Marín‐Serrano, Stefan Stewart, Belén Bardón Rivera, Jesús Marı́n, Lucía Martínez de Soto, Enrique Seco Meseguer, Elena Ramı́rez   +8 more
openalex   +1 more source

Morin Attenuates Diclofenac‐Induced Hepatocellular Death Injury via Nrf2/Ho‐1/NQO1, Beclin‐1/LC3A/LC3B and p53/Bax/Caspase Signalling Pathways

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 7, July 2025.
ABSTRACT Diclofenac (DF), a nonsteroidal and anti‐inflammatory drug, has limited use due to its adverse effects on the liver. On the other hand, morin, a bioflavonoid, has biological and pharmacological properties. This study aims to investigate whether morin may protect against diclofenac‐induced liver toxicity.
Nurhan Akaras, Hasan Şimşek, Cihan Gür, Sefa Küçükler, Mustafa İleritürk, Fatih Mehmet Kandemir   +5 more
wiley   +1 more source

Late-onset isavuconazole-induced liver injury

Medical Mycology Case Reports, 2018
Antifungal agents account for approximately 3% of Drug-Induced Liver Injury (DILI) cases. Isavuconazole is a novel triazole, and experience with long-term use of it is lacking.
Felix Bongomin, Isabel Rodriguez-Goncer, Carol Lorden, Akaninyene Otu, Rohit Bazaz   +4 more
doaj  

Role of Gut Microecology in the Pathogenesis of Drug-Induced Liver Injury and Emerging Therapeutic Strategies

Molecules
Drug-induced liver injury (DILI) is a common clinical pharmacogenic disease. In the United States and Europe, DILI is the most common cause of acute liver failure.
Yuqiao Huang, Yu Zhang, Kaireng Wu, Xinxin Tan, Tian Lan, Guixiang Wang   +5 more
doaj   +1 more source

Drug Liver Injury Induced by Olmesartan Mediated by Autoimmune-Like Mechanism: A Case Report

European Journal of Case Reports in Internal Medicine, 2020
Autoimmune hepatitis (AIH) was the first liver disease for which an effective therapeutic intervention was carried out, using prednisolone; its usefulness was demonstrated in several clinical trials.
Manuel de la Torre-Aláez, Mercedes Iñarrairaegui   +1 more
doaj   +1 more source

Incidence and prevalence of acute hepatitis E virus infection in patients with suspected Drug‐Induced Liver Injury in the Spanish DILI Registry [PDF]

, 2020
Judith Sanabria‐Cabrera, Rocío Sanjuán‐Jiménez, Encarnación Clavijo, Inmaculada Medina‐Cáliz, A. González-Jiménez, Miren García‐Cortés, Aida Ortega‐Alonso, Miguel Jiménez‐Pérez, Rocío González‐Grande, Camilla Stephens, Mercedes Robles‐Díaz, M. Isabel Lucena, Raúl J. Andrade   +12 more
openalex   +1 more source

Research progress of mitochondrial dysfunction in drug-induced liver injury [PDF]

Yixue xinzhi zazhi
Drug-induced liver injury (DILI) is a type of drug-induced liver injury with complex and diverse mechanisms that can lead to liver failure in severe cases, thereby affecting patients' quality of life and survival.
SUN Huijuan, HU Wenkai, LIU Shumin
doaj   +1 more source