Results 111 to 120 of about 2,582,050 (300)

Second‐hit DEPDC5 mutation is limited to dysmorphic neurons in cortical dysplasia type IIA

Annals of Clinical and Translational Neurology, 2019
Focal cortical dysplasia (FCD) causes drug‐resistant epilepsy and is associated with pathogenic variants in mTOR pathway genes. How germline variants cause these focal lesions is unclear, however a germline + somatic “2‐hit” model is hypothesized.
Wei Shern Lee, Sarah E. M. Stephenson, Katherine B. Howell, Kate Pope, Greta Gillies, Alison Wray, Wirginia Maixner, Simone A. Mandelstam, Samuel F. Berkovic, Ingrid E. Scheffer, Duncan MacGregor, Anthony Simon Harvey, Paul J. Lockhart, Richard J. Leventer   +13 more
doaj   +1 more source

Report of the 2003 National Conference on Public Health and Epilepsy [PDF]

I. Executive Summary -- II. Introduction -- III. Living Well with Epilepsy II Conference -- -- IV. Review and Recommendations -- -- Workgroup A: Early Recognition, Diagnosis and Treatment -- -- Workgroup B: Epidemiology and Surveillance -- -- Workgroup C:
National Conference on Public Health and Epilepsy (2003 : Baltimore, MD)
core  

Clozapine:norclozapine ratio as a marker of metabolic risk and therapeutic response and effect of valproate on clozapine levels

British Journal of Clinical Pharmacology, EarlyView.
Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask, Miina Lamminmäki, Olli Kampman, Mari Hämäläinen, Eeva Moilanen, Niko Seppälä, Anssi Solismaa   +6 more
wiley   +1 more source

The impact of medication shortages on paediatric care: A retrospective impact analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Medication shortages are a growing global concern, with potentially greater consequences in paediatric patients because of the limited availability of safe, evidence‐based and appropriately formulated medication. This study aimed to evaluate the impact of medication shortages on paediatric patients by assessing the suitability and safety of ...
Maaike Johanna Rutten ‐ van Kranenburg, Laurens Christiaan van Rijn, Elisabeth Johanna Ruijgrok, Sinno Henricus Paulus Simons, Brigitta Carolina Maria Witjes, Jan‐Dietert Christoffer Brugma, Robert Bernard Flint   +6 more
wiley   +1 more source

Ketogenic dietary therapy utilization in Kenya: A qualitative exploration of dietitian’s perceptions

Epilepsy & Behavior Reports
This study utilized a qualitative design to explore dietitians’ perceptions regarding Ketogenic Diet Therapy (KDT) for patients with drug-resistant epilepsy in Kenya. Dietitians from Kenya were selected and consented.
Pauline Samia, Violet Naanyu, J Helen Cross, Richard Idro, Paul Boon, Jo Wilmshurst, Stanley Luchters   +6 more
doaj   +1 more source

Clinical features, proximate causes, and consequences of active convulsive epilepsy in Africa. [PDF]

, 2013
PURPOSE: Epilepsy is common in sub-Saharan Africa (SSA), but the clinical features and consequences are poorly characterized. Most studies are hospital-based, and few studies have compared different ecological sites in SSA. We described active convulsive
Adjei, Patrick, Tollman, Stephen, Mageto, James O, Seeds writing group,, Mathew, Alexander, Ae-Ngibise, Ken, Collinson, Mark, Matuja, William, Ngugi, Anthony K, Twine, Rhian, Newton, Charles RJC, Agbokey, Francis, Kamuyu, Gathoni, Kariuki, Symon M., Mageto, James O., Masanja, Honratio, Neville, Brian GR, Nutman, Thomas, Ndyomughenyi, Donald, Akpalu, Albert, Pariyo, George, Peterson, Stefan, Neville, Brian G. R., Kakooza-Mwesige, Angelina, Wilkins, Patricia, Chengo, Eddie, Kleinschmidt, Immo, Owusu-Agyei, Seth, Odera, Victor Mung'ala, Gómez Olivé, F Xavier, Doku, Victor CK, Wagner, Ryan G, Bauni, Evasius, Sander, Josemir W., Akpalu, Bright, Doku, Victor C. K., Bottomley, Christian, Wagner, Ryan G., SEEDS writing group, Ngugi, Anthony K., Newton, Charles R. J. C., Odermatt, Peter, Chabi, Martin, Gómez Olivé, F. Xavier, Odhiambo, Rachael, White, Steven, Connor, Myles, Kahn, Kathleen, Noh, John, Kariuki, Symon M, Sander, Josemir W   +50 more
core   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Cenobamate use in super‐refractory status epilepticus: A report of three cases

Epileptic Disorders, EarlyView.
Abstract Objectives Super‐refractory status epilepticus (SRSE) is a neurological emergency with high morbidity and mortality. Cenobamate, a novel antiseizure medication, may be helpful in managing SRSE, but evidence is limited. Methods This retrospective case series reports the use of cenobamate as add‐on therapy in the management of three cases of ...
Marina Romozzi, Juan Luis Alcala‐Zermeno, Antonio Funcis, Federico Tosto, Marta Piccioli, Luigi Francesco Iannone, Riccardo Maviglia, Masahito Katsuki, Yasuhiko Matsumori, Paolo Calabresi, Raffaele Iorio, Catello Vollono   +11 more
wiley   +1 more source

Epilepsy educational curriculum for nurses: A report from the Nursing Section of the International League Against Epilepsy

Epileptic Disorders, EarlyView.
Abstract A comprehensive, competency‐based epilepsy curriculum is needed to strengthen nurses' capacity to care for people with epilepsy worldwide. Such a curriculum should be adaptable across nursing roles, practice settings, and geographic regions.
Patricia O. Shafer, Sandra Dewar, Ariane Bernier, Ludivine Rohrer, Nancy Santilli, Carmela Redhead, Tammy Gravel, Gagandeep Singh, Jane R. von Gaudecker   +8 more
wiley   +1 more source

Trends in drug-resistant tuberculosis in a gold-mining workforce in South Africa, 2002-2008. [PDF]

, 2012
SETTING AND OBJECTIVE: To describe trends in drug-resistant tuberculosis (TB) in two gold-mining workforces, South Africa, 2002-2008. DESIGN: TB programme data analysis.
Fielding, K. L., van Halsema, CL, Churchyard, GJ, Churchyard, G. J., Chihota, VN, Grant, AD, Chihota, V. N., Grant, A. D., Fielding, KL, van Halsema, C. L., Lewis, J. J., Lewis, JJ   +11 more
core   +1 more source