Results 191 to 200 of about 83,951 (257)

Spatial clusters of risk and cartography of care for drug-resistant tuberculosis. [PDF]

Rev Saude Publica
Ballestero JGA, Silva Júnior JNB, Arroyo LH, Pelissari DM, Rigolin IZ, Palha PF, Monroe AA, Ferreira QR, Leal GDC, Teixeira LO, Costa YBD, Pinto IC, Andrade RLP, Arcêncio RA.   +13 more
europepmc   +1 more source

The Current Landscape and Future Prospects of Vaccine Manufacturing in Africa: Challenges, Innovations, and Opportunities: A Narrative Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Africa has significant challenges in meeting its vaccination needs, including inadequate manufacturing capacity, infrastructure deficiencies, a scarcity of experienced personnel, regulatory hurdles, restricted access to technology and intellectual property.
Courage Chandipwisa, Agness Shimilimo, Olivier Uwishema, Helen Onyeaka   +3 more
wiley   +1 more source

Real-world effectiveness and safety of prolonged bedaquiline course in the treatment of drug-resistant tuberculosis-a multi-center retrospective cohort study in a country with a high burden of drug-resistant tuberculosis. [PDF]

Microbiol Spectr
Yu Y, Cao J, Pan H, Zhong H, Wu X, Yang J, Cheng L, Qu Q, Wang L, Lu F, Chen H, Wang J, Sha W, Sun Q.   +13 more
europepmc   +1 more source

Combined Oral Contraceptive Drug–Drug Interaction Study With Ganfeborole, a New Anti‐Tuberculosis Agent

The Journal of Clinical Pharmacology, Volume 66, Issue 3, March 2026.
Abstract New drugs are urgently needed to treat drug‐resistant tuberculosis in combination regimens. Ganfeborole demonstrated bactericidal activity and good tolerability in clinical trials. In preclinical studies, ganfeborole showed embryofetal developmental effects, currently mandating highly effective non‐user dependent contraception in women of ...
Laura Iavarone, Silvia M. Lavezzi, Antonio J. Carcas, Tetyana Chaychenko, Raquel Gabarro‐Carrion, Arturo Gómez López de las Huertas, Stephanie Gresham, Alicia Marín‐Candón, Sophie L. Penman, Katie Rolfe, Simon Tiberi, David Barros‐Aguirre, Alberto M. Borobia, the ERA4TB consortium   +13 more
wiley   +1 more source

Clinical evaluation of a commercial culture-free targeted next-generation sequencing test for diagnosis of drug-resistant tuberculosis. [PDF]

Microbiol Spectr
Miotto P, Colman RE, Cabibbe AM, Rancoita PMV, Di Marco F, De la Rossa A, Hoogland C, Uplekar S, Laurent S, Cirillo DM, Rodrigues C, Kambli P, Tukvadze N, Maghradze N, Omar SV, Joseph L, Suresh A, Rodwell TC.   +17 more
europepmc   +1 more source

Effect of the COVID-19 pandemic on drug-resistant tuberculosis treatment outcomes at a national referral hospital in Sierra Leone, 2017 to 2022: A retrospective cohort study. [PDF]

PLOS Glob Public Health
Koroma JA, Mahmoud M, Molleh B, Sevalie S, Chan AK, Mishra S, Lakoh S, Kanu JS.   +7 more
europepmc   +1 more source

Machine Learning Based Diagnostic Models for Hip and Knee Prosthetic Joint Infection: A Systematic Review

Journal of Orthopaedic Research, Volume 44, Issue 3, March 2026.
ABSTRACT Prosthetic joint infection (PJI) is a devastating complication that affects up to 1.7% of patients within 2 years following total hip arthroplasty (THA) or total knee arthroplasty (TKA). PJI is associated with significant patient morbidity, reduction in quality of life, prolonged hospitalisation, and healthcare expenditure.
Jaiden Nairne‐Nagy, Rudraksh Gupta, Boopalan Ramasamy, Lucian Bogdan Solomon, Stuart A. Callary   +4 more
wiley   +1 more source

Impact of the COVID-19 Pandemic on Drug-Resistant Tuberculosis in Europe: A Meta-Analysis of Epidemiological Trends. [PDF]

Pharmaceuticals (Basel)
Zouganeli C, Toubanaki DK, Karaoulani O, Vrioni G, Karagouni E, Efstathiou A.   +5 more
europepmc   +1 more source

Immune Exhaustion in Chronic Infection and Cancer: Signaling Pathways and Therapeutic Interventions

MedComm, Volume 7, Issue 3, March 2026.
Immune exhaustion is a well‐established hallmark of both cancer and chronic infection. This review proposes a novel “infection–exhaustion–tumor axis” framework, wherein chronic pathogens (e.g., oncogenic viruses) evade immune surveillance by hijacking inflammatory signaling to drive immune cell exhaustion, thereby creating immunosuppressive niches ...
Yali Song, Yazhi Mo, Si Chen, Yuemei Chen, Chunying Zhang, Shanying Deng, Juan Liao, Yi He, Wei Wang, Weidong Zheng, Tingting Zeng   +10 more
wiley   +1 more source