Results 71 to 80 of about 2,722,809 (208)

Drug-resistant tuberculosis in the 1990s [PDF]

open access: yesEuropean Respiratory Journal, 1995
There has been an upsurge of tuberculosis in many parts of the world in the past decade. The high rates of drug-resistant tuberculosis currently reported in many countries are alarming. The most catastrophic phenomenon is the emergence of multidrug-resistant strains of Mycobacterium tuberculosis.
W W, Yew, C H, Chau
openaire   +2 more sources

Negligible risk of inducing resistance in Mycobacterium tuberculosis with single-dose rifampicin as post-exposure prophylaxis for leprosy [PDF]

open access: yes, 2016
Post-exposure prophylaxis (PEP) for leprosy is administered as one single dose of rifampicin (SDR) to the contacts of newly diagnosed leprosy patients. SDR reduces the risk of developing leprosy among contacts by around 60 % in the first 2-3 years after ...
Richard Anthony   +55 more
core   +2 more sources

Extensively drug resistant tuberculosis [PDF]

open access: yesBMJ, 2006
Tuberculosis outbreaks in the developed world are newsworthy. However in the developing world where deaths from tuberculosis are common it takes something exceptional for an outbreak to attract much attention. In response to a recent report at the 16th international AIDS conference and to increasing South African media reports the World Health ...
Lawn, Stephen D, Wilkinson, Robert
openaire   +3 more sources

Label-Free Quantitative Proteomics Identifies Novel Plasma Biomarkers for Distinguishing Pulmonary Tuberculosis and Latent Infection

open access: yesFrontiers in Microbiology, 2018
The lack of effective differential diagnostic methods for active tuberculosis (TB) and latent infection (LTBI) is still an obstacle for TB control. Furthermore, the molecular mechanism behind the progression from LTBI to active TB has been not elucidated.
Huishan Sun   +11 more
doaj   +1 more source

A Prospective Assessment of Therapeutic Efficacy and Immune Effects of Levofloxacin and Ofloxacin in Multiple-Drug Resistant Tuberculosis

open access: yes, 2021
Background: Multi-drug resistant tuberculosis impairing the effectiveness of standard treatments may contribute to increased mortality. High failure and relapse rates are recorded when standard regimens are used for multi-drug resistant ...
Karagoz, Turan   +4 more
core  

Isoniazid preventive therapy and risk for resistant tuberculosis. [PDF]

open access: yes, 2006
In the context of tuberculosis (TB) resurgence, isoniazid preventive therapy (IPT) is increasingly promoted, but concerns about the risk for development of isoniazid-resistant tuberculosis may hinder its widespread implementation.
Grant, Alison D   +7 more
core   +1 more source

Identification of novel Imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB [PDF]

open access: yes, 2012
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB ...
Fernández, Raquel   +54 more
core   +2 more sources

The challenge of drug-resistant tuberculosis

open access: yesCleveland Clinic Journal of Medicine, 1994
CLINICAL ISSUES: After declining for decades, the incidence of tuberculosis is again increasing, and strains resistant to multiple drugs are appearing. The greatest increases in infection have been in blacks and Hispanics. The disease is most aggressive in patients infected with human immunodeficiency virus and in patients receiving immunosuppressive ...
openaire   +2 more sources

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3 [PDF]

open access: yes, 2013
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB.
Nalini Mehta   +114 more
core   +1 more source

Lefamulin harbors promising anti-tuberculosis activity against multidrug-resistant Mycobacterium tuberculosis isolates

open access: yesMicrobiology Spectrum
Multidrug-resistant tuberculosis (MDR-TB) is often associated with poor clinical outcomes. This study evaluated the in vitro activity of lefamulin (LEF) and intracellular activities against Mycobacterium tuberculosis.
Jing Wu   +5 more
doaj   +1 more source

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