Results 71 to 80 of about 2,897,181 (203)

Identification of novel Imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB [PDF]

, 2012
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB ...
Fernández, Raquel, Nicholas J Loman, Besra, Gurdyal S., Ballell, L, Raquel Fernández, Pallen, Mark J., Abrahams, Katherine A, Loman, Nicholas J., Abrahams, Katherine A., Spivey, VL, Constantinidou Chrystala, Mark J Pallen, Remuiñán, Modesto J, Cox, Jonathan A G, Abrahams Katherine A., Loman, Nicholas J, Carlos Alemparte, Lluis Ballell, Cox Jonathan A. G., Loman, NJ, Besra, GS, Constantinidou, Chrystala, Alemparte Carlos, Pallen, Mark J, Besra, Gurdyal S; id_orcid, Abrahams, KA, Remuiñán, Modesto J., Besra Gurdyal S., Remuiñán Modesto J., Vickey L Spivey, Chrystala Constantinidou, Pallen, MJ, Barros, D, Loman Nicholas J., Ballell, Lluis, Fernández, R, Alemparte, Carlos, Cox, Jonathan A. G., Cox, JA, Modesto J Remuiñán, Barros David, Jonathan A G Cox, Gurdyal S Besra, Fernández Raquel, Spivey, Vickey L., David Barros, Constantinidou, C, Ballell Lluis, Spivey Vickey L., Barros, David, Spivey, Vickey L, Pallen Mark J., Remuiñán, MJ, Alemparte, C, Katherine A Abrahams   +54 more
core   +2 more sources

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3 [PDF]

, 2013
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB.
Nalini Mehta, Joaquín Rullás, Minick, Douglas J, María Martínez-Hoyos, Pallen, Mark J., Rebollo-López María José, Sousa, Verónica, Modesto J. Remuiñán (291058), Chrystala Constantinidou (161352), Johnson Afari, Pérez-Herrán Esther, Jorge Esquivias (403585), Jiménez, Elena, Jiménez Elena, Dow, David J, Constantinidou Chrystala, Fátima Ortega-Muro, Remuiñán, Modesto J, Esquivias Jorge, Fátima Ortega-Muro (403586), Mendoza-Losana, Alfonso, Pallen, Mark J, Lluís Ballell (2196634), Rullás, Joaquín, Besra, Gurdyal S; id_orcid, Vickey L Spivey, María Teresa Fraile-Gabaldón, Carolina González, Sousa Verónica, González, Carolina, Mónica Cacho, Ballell, Lluís, Martínez-Hoyos María, Elena Jiménez (47475), Carolina González (321712), María José Rebollo-López, Pérez-Herrán, Esther, Johnson Afari (403583), Esquivias, Jorge, Spivey, Vickey L., Nicholas J. Loman (126279), Verónica Sousa, Mehta, Nalini, Rebollo-López, María José, Cacho Mónica, Angulo-Barturen, Iñigo, Spivey Vickey L., Barros, David, Vickey L. Spivey (291055), Spivey, Vickey L, Esther Pérez-Herrán, Minick Douglas J., Alfonso Mendoza-Losana (403592), Cacho, Mónica, Nicholas J Loman, Lluís Ballell, Alfonso Mendoza-Losana, Besra, Gurdyal S., Dow David J., Loman, Nicholas J., Mehta Nalini, David J. Dow (403582), Afari, Johnson, Nicholas Cammack (403593), Rullás Joaquín, Iñigo Angulo-Barturen, Esther Pérez-Herrán (403580), Mark J Pallen, Loman, Nicholas J, Carlos Alemparte, Constantinidou, Chrystala, Alemparte Carlos, Fraile-Gabaldón, María Teresa, David J Dow, Douglas J Minick, Remuiñán, Modesto J., Besra Gurdyal S., Gurdyal S. Besra (37660), Remuiñán Modesto J., Chrystala Constantinidou, Mark J. Pallen (8904), Cammack, Nicholas, Ortega-Muro, Fátima, Mendoza-Losana Alfonso, Joaquín Rullás (5654542), Dow, David J., Angulo-Barturen Iñigo, Loman Nicholas J., Nalini Mehta (403584), Alemparte, Carlos, Minick, Douglas J., David Barros (291059), María Teresa Fraile-Gabaldón (403587), Modesto J Remuiñán, Barros David, María Martínez-Hoyos (403581), Mónica Cacho (403589), Cammack Nicholas, Ortega-Muro Fátima, Elena Jiménez, Carlos Alemparte (291057), Afari Johnson, Gurdyal S Besra, Fraile-Gabaldón María Teresa, Martínez-Hoyos, María, David Barros, Iñigo Angulo-Barturen (47469), Ballell Lluís, González Carolina, Douglas J. Minick (403588), Jorge Esquivias, María José Rebollo-López (403590), Pallen Mark J., Nicholas Cammack, Verónica Sousa (403591)   +114 more
core   +1 more source

Lefamulin harbors promising anti-tuberculosis activity against multidrug-resistant Mycobacterium tuberculosis isolates

Microbiology Spectrum
Multidrug-resistant tuberculosis (MDR-TB) is often associated with poor clinical outcomes. This study evaluated the in vitro activity of lefamulin (LEF) and intracellular activities against Mycobacterium tuberculosis.
Jing Wu, Yuanfei Ji, Weihe Zhang, Siyi Chen, Yao Dong, Xia Yu   +5 more
doaj   +1 more source

An evaluation of Innowave MTB/RIF/INH assay versus Xpert MTB/RIF for rapid identification of Mycobacterium tuberculosis and drug resistance in bone and joint specimens from people with suspected osteoarticular tuberculosis

Microbiology Spectrum
Osteoarticular tuberculosis (TB) is hard to diagnose. We prospectively evaluated a novel molecular test, Innowave MTB/RIF/INH (InnowaveDX), against culture and Xpert MTB/RIF (Xpert)/MeltPro TB for detecting Mycobacterium tuberculosis (MTB) and rifampicin
Qiang Liu, Fen Wang, Haoran Wang, Guanglu Jiang, Adong Shen, Hairong Huang, Suting Chen   +6 more
doaj   +1 more source

Patterns of rpoC mutations in drug-resistant mycobacterium tuberculosis isolated from patients in South Korea

, 2018
Background: Rifampicin (RFP) is one of the principal first-line drugs used in combination chemotherapies against Mycobacterium tuberculosis, and its use has greatly shortened the duration of chemotherapy for the successful treatment of drug-susceptible ...
윤여준
core   +1 more source

Microscopic-observation drug-susceptibility assay for the diagnosis of TB. [PDF]

, 2006
BACKGROUND: New diagnostic tools are urgently needed to interrupt the transmission of tuberculosis and multidrug-resistant tuberculosis. Rapid, sensitive detection of tuberculosis and multidrug-resistant tuberculosis in sputum has been demonstrated in ...
Doris LaChira, Sanchez, Eduardo, Jorge Coronel, Luz Caviedes, Friedland, Jon S, Maria-Graciela Hollm-Delgado, Coronel, Jorge, Robert H. Gilman, Juan Carlos Saravia, Moore, David AJ, Yvette Piñedo, Caviedes, Luz, Oberhelman, Richard, Piñedo, Yvette, A. Roderick Escombe, Saravia, Juan Carlos, Cayo Salazar, Jon S. Friedland, Gilman, Robert H, Hollm-Delgado, Maria-Graciela, Vivar, Aldo, LaChira, Doris, David A.J. Moore, Eduardo Sanchez, Salazar, Cayo, Richard Oberhelman, Evans, Carlton AW, Aldo Vivar, Carlton A.W. Evans, Escombe, A Roderick, Friedland, Jon S., Evans, Carlton A.W., Moore, David A.J., Gilman, Robert H., Escombe, A. Roderick   +34 more
core   +1 more source

Good quality locally procured drugs can be as effective as internationally quality assured drugs in treating multi-drug resistant tuberculosis. [PDF]

, 2015
BACKGROUND: Owing toGiven the high costs of drugs to treat multi-drug resistant tuberculosis (MDR-TB), the Green Light Committee (GLC) initiative enables TB programs to procure quality-assured drugs at reduced prices.
David Moore, Qazi, Fahad, Qadeer Ejaz, Qazi Fahad, Moore David, Moore D., Fahad Qazi, Katherine Fielding, Fatima R., Khan M.S., Khan, Mishal S, Mishal S Khan, Qadeer E., Qazi F., Ejaz Qadeer, Qadeer, Ejaz, Fielding Katherine, Fielding, Katherine, Moore, David, Razia Fatima, Fatima Razia, Fielding K., Fatima, Razia, Khan Mishal S.   +23 more
core   +1 more source

Investigation of the cell composition and gene expression in the delayed-type hypersensitivity tuberculin skin test

Military Medical Research, 2023
Hui-Juan Duan, Hong-Qian Chu, Ting-Ming Cao, Guang-Ming Dai, Na Tian, Gang Sheng, Zhao-Gang Sun   +6 more
doaj   +1 more source

The challenge of drug-resistant tuberculosis

Cleveland Clinic Journal of Medicine, 1994
CLINICAL ISSUES: After declining for decades, the incidence of tuberculosis is again increasing, and strains resistant to multiple drugs are appearing. The greatest increases in infection have been in blacks and Hispanics. The disease is most aggressive in patients infected with human immunodeficiency virus and in patients receiving immunosuppressive ...
openaire   +2 more sources

Transmission of multidrug-resistant tuberculosis in the UK: a cross-sectional molecular and epidemiological study of clustering and contact tracing [PDF]

, 2014
BACKGROUND: Between 2000 and 2012 the number of multidrug-resistant (MDR) tuberculosis cases in the UK increased from 28 per year to 81 per year. We investigated the proportion of MDR tuberculosis cases arising from transmission in the UK and associated ...
Watson, JP, Abubakar, I, Mullarkey, C, Anderson, LF, Tamne, S, Zenner, D, Brown, T   +6 more
core