Results 51 to 60 of about 2,722,809 (208)

Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues [PDF]

, 2013
Defining the pharmacological target(s) of currently used drugs and developing new analogues with greater potency are both important aspects of the search for agents that are effective against drug-sensitive and drug-resistant Mycobacterium tuberculosis ...
Derek Craig, Rosa Milagros Corrales, Craig Derek, Gannoun-Zaki, Laila, Geoffrey D Coxon, Laila Gannoun-Zaki, Laurent Kremer, Gannoun-Zaki Laila, Emilie Vialla, Herrmann, Jean Louis, Coxon, Geoffrey, Corrales, Rosa Milagros, Coxon Geoffrey D., Vialla, Emilie, Kremer Laurent, Kremer, Laurent, Corrales Rosa Milagros, Vialla Emilie, Craig, Derek   +18 more
core   +5 more sources

International spread of MDR TB from Tugela Ferry, South Africa. [PDF]

, 2011
We describe a death associated with multidrug-resistant tuberculosis and HIV infection outside Africa that can be linked to Tugela Ferry (KwaZulu-Natal, South Africa), the town most closely associated with the regional epidemic of drug-resistant ...
Beaton, R Kate, John, Laurence, Simon Ashworth, Onn Kon, Alexander Pym, O. Martin Williams, Kon, Onn Min, Richard J. Lessells, Alexander S. Pym, Williams, O Martin, Graham Cooke, Pym, Alexander S, Onn Min Kon, Graham S. Cooke, Cooke, Graham S, Moodley, P, Supply, P, R. Kate Beaton, P. Supply, Laurence John, Lessells, Richard J, Ashworth, Simon, Richard Lessells, P. Moodley   +23 more
core   +1 more source

AceE affects the optimum growth and biofilm formation of Mycobacterium tuberculosis via cell wall lipid remodeling

mSystems
Central carbon metabolism is fundamental to the growth and virulence of Mycobacterium tuberculosis (Mtb). The aceE gene encodes the E1 subunit of the pyruvate dehydrogenase complex that irreversibly converts pyruvate to acetyl-CoA. There, we investigated
Suting Chen, Jifang Zheng, Qiang Liu, Tianlu Teng, Ziyi Yang, Fengmin Huo, Yi Xue, Liang Li, Hairong Huang   +8 more
doaj   +1 more source

Change in prevalence and molecular characteristics of isoniazid-resistant tuberculosis over a 10-year period in China

BMC Infectious Diseases, 2019
Background Isoniazid (INH) represents the cornerstone for the treatment of cases infected with Mycobacterium tuberculosis (MTB) strains. Several molecular mechanisms have been shown to be the major causes for INH resistance, while the dynamic change of ...
Fengmin Huo, Jie Lu, Zhaojing Zong, Wei Jing, Jin Shi, Yifeng Ma, Lingling Dong, Liping Zhao, Yufeng Wang, Hairong Huang, Yu Pang   +10 more
doaj   +1 more source

Assessment of current diagnostic algorithm for detection of mixed infection with Mycobacterium tuberculosis and nontuberculous mycobacteria

Journal of Infection and Public Health, 2020
Background: The increasing pulmonary diseases are reported to be affected by mixed infection of Mycobacterium tuberculosis (MTB) and nontuberculous mycobacteria (NTM).
Qian Liang, Yuanyuan Shang, Fengmin Huo, Yi Xue, Yunxu Li, Lingling Dong, Shanshan Li, Yu Pang   +7 more
doaj   +1 more source

In vitro susceptibility of nontuberculous mycobacteria in China

BMC Infectious Diseases
Objectives This study aimed to measure the prevalence of resistance to antimicrobial agents, and explore the risk factors associated with drug resistance by using nontuberculous Mycobacteria (NTM) isolates from China.
Weicong Ren, Yaoju Tan, Zichun Ma, Yuanyuan Shang, Shanshan Li, Xuxia Zhang, Wei Wang, Cong Yao, Jinfeng Yuan, Liang Li, Yu Pang   +10 more
doaj   +1 more source

Bone penetration of linezolid in osteoarticular tuberculosis patients of China

International Journal of Infectious Diseases, 2021
Background: Linezolid presents strong antimicrobial activity against multidrug-resistant (MDR) pulmonary tuberculosis (TB), but its application in osteoarticular tuberculosis treatment remains understudied.
Shu’an Wen, Tingting Zhang, Xia Yu, Weijie Dong, Tinglong Lan, Jun Fan, Yi Xue, Fen Wang, Lingling Dong, Shibing Qin, Hairong Huang   +10 more
doaj   +1 more source

M. tuberculosis genotypic diversity and drug susceptibility pattern in HIV-infected and non-HIV-infected patients in northern Tanzania. [PDF]

, 2007
Contains fulltext : 53004.pdf (Publisher’s version ) (Open Access)BACKGROUND: Tuberculosis (TB) is a major health problem and HIV is the major cause of the increase in TB.
Boeree, M.J., Sola Christophe, Martin Boeree, Kibiki, Gibson S, Mulder, Bert, van Soolingen Dick, Jessica L de Beer, de Beer Jessica L, Bert Mulder, Dolmans, Wil M V, Mulder, B., Boeree Martin, Christophe Sola, van der Zanden, Adri G M, Dolmans Wil MV, Beer, J.L. de, Dolmans, W.M.V., Kibiki, G.S., Dick van Soolingen, Mulder Bert, Boeree, Martin, de Beer, Jessica L, Soolingen, D. van, Sam, N., Kibiki Gibson S, van der Zanden Adri GM, Noel Sam, van Soolingen, Dick, Sam Noel, Sola, Christophe, Adri GM van der Zanden, Gibson S Kibiki, Zanden, A.G. van der, Sola, C., Wil MV Dolmans, Sam, Noel   +35 more
core   +2 more sources

Performance of stool-based Xpert MTB/RIF assay in the diagnosis of presumptive pulmonary tuberculosis in adults unable to expectorate sputum

Microbiology Spectrum
This study aimed to compare the performance of stool-based Xpert MTB/RIF(Xpert) assay (Cepheid, USA) against that of smear, culture, and Xpert using respiratory tract specimens (RTS) and stool samples in the diagnosis of adult pulmonary tuberculosis (PTB)
Yi Xue, Siyi Chen, Weihe Zhang, Junnan Jia, Fen Wang, Lingling Dong, Liping Zhao, Hairong Huang, Xia Yu   +8 more
doaj   +1 more source

Xpert MTB/RIF and GenoType MTBDRplus assays for the rapid diagnosis of bone and joint tuberculosis

International Journal of Infectious Diseases, 2015
Background: Bone and joint tuberculosis (BJTB) constitutes about 10–20% of the extrapulmonary tuberculosis (EPTB) cases in China. The GenoType MTBDRplus assay (MTBDR) has been endorsed by the World Health Organization (WHO) for the diagnosis of pulmonary
Yunting Gu, Guirong Wang, Weijie Dong, Yunxu Li, Yifeng Ma, Yuanyuan Shang, Shibing Qin, Hairong Huang   +7 more
doaj   +1 more source