Results 41 to 50 of about 86,450 (250)
BMC Infectious Diseases, 2019 Background Isoniazid (INH) represents the cornerstone for the treatment of cases infected with Mycobacterium tuberculosis (MTB) strains. Several molecular mechanisms have been shown to be the major causes for INH resistance, while the dynamic change of ...
Fengmin Huo +10 more
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Drug Resistance in Tuberculosis
Annals of Saudi Medicine, 1990 Resistance to antituberculosis drugs is due to the occurrence of resistant mutants in the bacterial population even before exposure to these drugs. These mutations are chromosomal in origin. Resistance occurs when the bacterial population is large or when drugs are used alone. Potent drugs such as rifampicin, isoniazid and streptomycin are effective in
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Treatment of Drug-Resistant Tuberculosis [PDF]
Clinics in Chest Medicine, 2019 The treatment of drug-resistant tuberculosis (TB) is complicated and has evolved significantly in the past decade with the advent of rapid molecular tests and updated evidence-based guidelines of the World Health Organization and other organizations.
Sundari R, Mase, Terence, Chorba
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Advanced Science, EarlyView.ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang +11 more
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In vitro susceptibility of nontuberculous mycobacteria in China
BMC Infectious DiseasesObjectives This study aimed to measure the prevalence of resistance to antimicrobial agents, and explore the risk factors associated with drug resistance by using nontuberculous Mycobacteria (NTM) isolates from China.
Weicong Ren +10 more
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Microbiology SpectrumThis study aimed to compare the performance of stool-based Xpert MTB/RIF(Xpert) assay (Cepheid, USA) against that of smear, culture, and Xpert using respiratory tract specimens (RTS) and stool samples in the diagnosis of adult pulmonary tuberculosis (PTB)
Yi Xue +8 more
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Xpert MTB/RIF and GenoType MTBDRplus assays for the rapid diagnosis of bone and joint tuberculosis
International Journal of Infectious Diseases, 2015 Background: Bone and joint tuberculosis (BJTB) constitutes about 10–20% of the extrapulmonary tuberculosis (EPTB) cases in China. The GenoType MTBDRplus assay (MTBDR) has been endorsed by the World Health Organization (WHO) for the diagnosis of pulmonary
Yunting Gu +7 more
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Case report: A 9-year systematic treatment failure of a pulmonary tuberculosis patient
Frontiers in Public Health, 2022 ObjectiveTo explore the reasons of failure in a case of pulmonary tuberculosis (PTB) after 9 years systematic treatment.MethodsWe extracted the patients' treatment history, drug susceptibility testing (DST), Computed tomography (CT) images, and sequenced
Hui Jiang +30 more
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Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management
Advanced Science, EarlyView.ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak +9 more
wiley +1 more source
Frontiers in Immunology, 2022 False negative interferon-γ release assay (IGRA) results constitute the major dilemma for the diagnosis of tuberculosis (TB) infections. Herein, we conducted a cohort study to compare the host immunological response to TB-specific antigens between active
Qiang Li +8 more
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