Results 21 to 30 of about 2,722,809 (208)

Extremely high levels of central nervous system involvement in miliary tuberculosis

BMC Infectious Diseases, 2022
Background Miliary tuberculosis (TB) is one of the severest manifestations of TB that can be lethal when concomitant with the central nervous system (CNS) involvement.
Guirong Wang, Ruixia Liang, Qing Sun, Xinlei Liao, Chenqian Wang, Hairong Huang   +5 more
doaj   +1 more source

Drug Resistance in Tuberculosis [PDF]

Journal of Tropical Pediatrics, 2007
Tuberculosis (TB) kills about 2 million adults and around 100 000 children every year. One-third of the worlds population are currently infected with Mycobacterium tuberculosis and many have active disease. In Europe TB emerged as a major disease in the latter part of the 14th century.
openaire   +2 more sources

Programmatically selected multidrug-resistant strains drive the emergence of extensively drug-resistant tuberculosis in South Africa [PDF]

, 2013
South Africa shows one of the highest global burdens of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). Since 2002, MDR-TB in South Africa has been treated by a standardized combination therapy, which until 2010 included
Pillay, Manormoney, van Helden, Paul D., Nicolaas C. Gey van Pittius (173264), Paul D. van Helden (33594), Marlein E Bosman, Gagneux, Sebastien, Thomas C Victor, Manormoney Pillay (257769), Nicolaas C Gey van Pittius, Borna Müller (173253), Hayes, Cindy, Streicher, Elizabeth M., Andre Trollip (449922), Robin M Warren, Elizabeth M Streicher, Trollip, Andre, Violet N. Chihota (143307), Warren, Robin M., Bosman, Marlein E., Müller, Borna, Violet N Chihota, Cindy Hayes, Marisa Klopper (398815), Cindy Hayes (449923), Elizabeth M. Streicher (439727), Borna Müller, Paul D van Helden, Marlein E. Bosman (449924), Klopper, Marisa, Gerrit Coetzee, Sebastien Gagneux (149824), Chihota, Violet N., Andre Trollip, Marisa Klopper, Sebastien Gagneux, Gerrit Coetzee (296078), Victor, Thomas C., Manormoney Pillay, Coetzee, Gerrit, Gey van Pittius, Nicolaas C., Robin M. Warren (33593), Thomas C. Victor (185348)   +41 more
core   +2 more sources

Drug-Resistant Tuberculosis

Clinical Infectious Diseases, 1993
Multidrug-resistant tuberculosis (MDRTB) is an iatrogenic disease that is emerging as a major infectious disease problem throughout the world. The AIDS pandemic, increased incidence of tuberculosis in populations with easy access to antituberculosis medications, the deterioration of the public health infrastructure, and inadequate training of health ...
B A, Hanna, S, Bonk, L K, Tick
openaire   +4 more sources

Drug resistance-conferring mutations in Mycobacterium tuberculosis from Madang, Papua New Guinea [PDF]

, 2012
: BACKGROUND: Monitoring drug resistance in Mycobacterium tuberculosis is essential to curb the spread of tuberculosis (TB). Unfortunately, drug susceptibility testing is currently not available in Papua New Guinea (PNG) and that impairs TB control in ...
Gagneux, S., Siba Peter, Beck, H. P., Hans-Peter Beck, Beck Hans-Peter, Carter Robyn, Paul Harino, Harino, P., Carter, R., Serej Ley, Ley Serej, Siba, P., Gagneux Sebastien, Borrell Sonia, Coscolla Mireia, Mireia Coscolla, Ballif Marie, Stefan Niemann, Ley, S., Marie Ballif, Coulter, C., Robyn Carter, Coulter Christopher, Christopher Coulter, Ballif, M., Peter Siba, Niemann, S., Harino Paul, Niemann Stefan, Sebastien Gagneux, Phuanukoonnon, S., Borrell, S., Coscolla, M., Sonia Borrell, Suparat Phuanukoonnon, Phuanukoonnon Suparat   +35 more
core   +1 more source

New drugs and vaccines for drug-resistant Mycobacterium tuberculosis infections [PDF]

, 2008
Tuberculosis remains the most common cause of death due to a single infective organism. Despite the availability of a vaccine and chemotherapeutic options, the global disease burden remains relatively unaffected.
Willcox, Benjamin, Gurdyal S Besra, Bhatt, Apoorva; id_orcid, Dover, LG, Apoorva Bhatt, Dover, Lynn, Besra, Gurdyal; id_orcid, Besra, Gurdyal, Bhatt, Apoorva, Lynn G Dover, Bhowruth, Veemal, Veemal Bhowruth, Benjamin E Willcox   +12 more
core   +1 more source

In Vitro Activity of the Sudapyridine (WX-081) against Non-Tuberculous Mycobacteria Isolated in Beijing, China

Microbiology Spectrum, 2022
Sudapyridine (WX-081) is a structural analog of bedaquiline (BDQ), which shows an anti-tuberculosis activity but, unlike BDQ, did not prolong QT interval (QT) in animal model studies.
Rui Zhu, Yuanyuan Shang, Suting Chen, Hua Xiao, Ruyan Ren, Fen Wang, Yi Xue, Lei Li, Yongguo Li, Naihui Chu, Hairong Huang   +10 more
doaj   +1 more source

Transmission of multidrug-resistant tuberculosis in the UK: a cross-sectional molecular and epidemiological study of clustering and contact tracing [PDF]

, 2014
BACKGROUND: Between 2000 and 2012 the number of multidrug-resistant (MDR) tuberculosis cases in the UK increased from 28 per year to 81 per year. We investigated the proportion of MDR tuberculosis cases arising from transmission in the UK and associated ...
Abubakar, Ibrahim, Anderson, Laura F, Brown, Timothy, Watson, JP, Abubakar, I, Tamne, Surinder, Mullarkey, C, Anderson, LF, Tamne, S, Zenner, D, Brown, T, Mullarkey, Catherine, Watson, John P, Zenner, Dominik   +13 more
core   +1 more source

Comparison of the in vitro antibacterial activity of ofloxacin, levofloxacin, moxifloxacin, sitafloxacin, finafloxacin, and delafloxacin against Mycobacterium tuberculosis strains isolated in China

Heliyon, 2023
Objective: The resistance of Mycobacterium tuberculosis (Mtb) to currently available fluoroquinolones (FQs), namely ofloxacin (OFX), levofloxacin (LFX), and moxifloxacin (MFX), renders the treatment of TB infections less successful.
Yaoyao Kong, Zhi Geng, Guanglu Jiang, Junnan Jia, Fen Wang, Xiaoyi Jiang, Yuzhen Gu, Zhenyan Qi, Naihui Chu, Hairong Huang, Xia Yu   +10 more
doaj   +1 more source

Exploring prospects of novel drugs for tuberculosis [PDF]

, 2012
Tuberculosis remains a disease with an enormous impact on public health worldwide. With the continuously increasing epidemic of drug-resistant tuberculosis, new drugs are desperately needed. However, even for the treatment of drug-sensitive tuberculosis,
Pieters, J., Grobusch, Martin P., Pieters, Jean, Janssen, Saskia, Zinsstag, Jakob, Janssen, S., Grobusch, M. P., Jayachandran, Rajesh, Khathi, Lulama, Khathi, L., Jayachandran, R., Zinsstag, J.   +11 more
core   +1 more source