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Drug resistant tuberculosis [PDF]

BMJ, 1995
EDITOR,—Concern is growing over the spread of drug resistant Mycobacterium tuberculosis. New evidence suggests that this spread may be increasing in certain sections of the British population. The recent advances in molecular techniques have equipped us with the means to make substantial inroads into the possible impact of drug resistant tuberculosis.1
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Extensively drug-resistant tuberculosis [PDF]

Current Opinion in Infectious Diseases, 2009
To describe the origin, epidemiology, diagnosis, treatment, prevention, and control of extensively drug-resistant tuberculosis (XDR TB).XDR TB is defined as the occurrence of TB in persons whose Mycobacterium tuberculosis isolates are resistant to isoniazid and rifampin and to any fluoroquinolone and at least one of three injectable second-line drugs ...
Mandeep, Jassal, William R, Bishai
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Comparison of the in vitro activity of linezolid, tedizolid, sutezolid, and delpazolid against rapidly growing mycobacteria isolated in Beijing, China

International Journal of Infectious Diseases, 2021
Background: The natural resistance of rapidly growing mycobacteria (RGM) to multiple antibiotics renders the treatment of the infections caused less successful.
Shu’an Wen, Xiaopan Gao, Weijie Zhao, Fengmin Huo, Guanglu Jiang, Lingling Dong, Liping Zhao, Fen Wang, Xia Yu, Hairong Huang   +9 more
doaj   +1 more source

Extremely high levels of central nervous system involvement in miliary tuberculosis

BMC Infectious Diseases, 2022
Background Miliary tuberculosis (TB) is one of the severest manifestations of TB that can be lethal when concomitant with the central nervous system (CNS) involvement.
Guirong Wang, Ruixia Liang, Qing Sun, Xinlei Liao, Chenqian Wang, Hairong Huang   +5 more
doaj   +1 more source

Application of Amplicon-Based Targeted NGS Technology for Diagnosis of Drug-Resistant Tuberculosis Using FFPE Specimens

Microbiology Spectrum, 2022
Next-generation sequencing (NGS) enables rapid identification of common and rare drug-resistant genetic variations from tuberculosis (TB) patients’ sputum samples and MTB isolates.
Jing Song, Weili Du, Zichen Liu, Jialu Che, Kun Li, Nanying Che   +5 more
doaj   +1 more source

The aceE involves in mycolic acid synthesis and biofilm formation in Mycobacterium smegmatis

BMC Microbiology, 2020
Background The integrity of cell wall structure is highly significant for the in vivo survival of mycobacteria. We hypothesized that changes in morphology may indicate changes in cell wall metabolism and identified an aceE gene mutant (aceE-mut) which ...
Suting Chen, Tianlu Teng, Shuan Wen, Tingting Zhang, Hairong Huang   +4 more
doaj   +1 more source

Non-tuberculous mycobacterial disease: progress and advances in the development of novel candidate and repurposed drugs

Frontiers in Cellular and Infection Microbiology, 2023
Non-tuberculous mycobacteria (NTM) are opportunistic pathogens that can infect all body tissues and organs. In particular, the lungs are the most commonly involved organ, with NTM pulmonary diseases causing serious health issues in patients with ...
Yuzhen Gu, Wenjuan Nie, Hairong Huang, Xia Yu   +3 more
doaj   +1 more source

Drug-Resistant Tuberculosis

Clinical Infectious Diseases, 1993
Multidrug-resistant tuberculosis (MDRTB) is an iatrogenic disease that is emerging as a major infectious disease problem throughout the world. The AIDS pandemic, increased incidence of tuberculosis in populations with easy access to antituberculosis medications, the deterioration of the public health infrastructure, and inadequate training of health ...
B A, Hanna, S, Bonk, L K, Tick
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Comparison of the in vitro antibacterial activity of ofloxacin, levofloxacin, moxifloxacin, sitafloxacin, finafloxacin, and delafloxacin against Mycobacterium tuberculosis strains isolated in China

Heliyon, 2023
Objective: The resistance of Mycobacterium tuberculosis (Mtb) to currently available fluoroquinolones (FQs), namely ofloxacin (OFX), levofloxacin (LFX), and moxifloxacin (MFX), renders the treatment of TB infections less successful.
Yaoyao Kong, Zhi Geng, Guanglu Jiang, Junnan Jia, Fen Wang, Xiaoyi Jiang, Yuzhen Gu, Zhenyan Qi, Naihui Chu, Hairong Huang, Xia Yu   +10 more
doaj   +1 more source

In Vitro Activity of the Sudapyridine (WX-081) against Non-Tuberculous Mycobacteria Isolated in Beijing, China

Microbiology Spectrum, 2022
Sudapyridine (WX-081) is a structural analog of bedaquiline (BDQ), which shows an anti-tuberculosis activity but, unlike BDQ, did not prolong QT interval (QT) in animal model studies.
Rui Zhu, Yuanyuan Shang, Suting Chen, Hua Xiao, Ruyan Ren, Fen Wang, Yi Xue, Lei Li, Yongguo Li, Naihui Chu, Hairong Huang   +10 more
doaj   +1 more source