Results 31 to 40 of about 2,897,181 (203)

Comparison of the in vitro antibacterial activity of ofloxacin, levofloxacin, moxifloxacin, sitafloxacin, finafloxacin, and delafloxacin against Mycobacterium tuberculosis strains isolated in China

Heliyon, 2023
Objective: The resistance of Mycobacterium tuberculosis (Mtb) to currently available fluoroquinolones (FQs), namely ofloxacin (OFX), levofloxacin (LFX), and moxifloxacin (MFX), renders the treatment of TB infections less successful.
Yaoyao Kong, Zhi Geng, Guanglu Jiang, Junnan Jia, Fen Wang, Xiaoyi Jiang, Yuzhen Gu, Zhenyan Qi, Naihui Chu, Hairong Huang, Xia Yu   +10 more
doaj   +1 more source

GeneXpert MTB/RIF assay in the diagnosis of urinary tuberculosis from urine specimens

Scientific Reports, 2017
Conventional bacteriological methods are not generally helpful in diagnosing urinary tuberculosis (UTB). GeneXpert is endorsed for the detection of pulmonary tuberculosis, whereas the data on its utility for urine specimens is limited.
Yu Pang, Yuanyuan Shang, Jie Lu, Qian Liang, Lingling Dong, Yunxu Li, Liping Zhao, Guanglu Jiang, Hairong Huang   +8 more
doaj   +1 more source

EasyNAT MTC assay: A simple, rapid, and low-cost cross-priming amplification method for the detection of mycobacterium tuberculosis suitable for point-of-care testing

Emerging Microbes and Infections, 2021
More sensitive, rapid, and affordable diagnostic tools for pulmonary tuberculosis (PTB) are urgently needed. This study aimed to assess the performance of EasyNAT MTC (abbreviation: EasyNAT) (Ustar Biotechnologies, China), a novel isothermal ...
Zhuman Zhang, Jian Du, Tao Liu, Fen Wang, Junnan Jia, Lingling Dong, Liping Zhao, Yi Xue, Guanglu Jiang, Xia Yu, Hairong Huang   +10 more
doaj   +1 more source

Biological interpretation of the sporadic sputum smear-positive-culture-negative outcome for patients with tuberculosis undertaking treatments

Frontiers in Public Health, 2023
IntroductionThe objective of the study was to identify the causes of smear-positive-culture-negative (S+/C–) outcomes of patients with tuberculosis during the treatment course.MethodsA laboratory-based retrospective study was performed at the Beijing ...
Jingjing Luo, Jingjing Luo, Jingjing Luo, Xia Yu, Lingling Dong, Fengmin Huo, Yifeng Ma, Qian Liang, Yuanyuan Shang, Hairong Huang   +9 more
doaj   +1 more source

Drug Resistance in Tuberculosis [PDF]

Journal of Tropical Pediatrics, 2007
Tuberculosis (TB) kills about 2 million adults and around 100 000 children every year. One-third of the worlds population are currently infected with Mycobacterium tuberculosis and many have active disease. In Europe TB emerged as a major disease in the latter part of the 14th century.
openaire   +2 more sources

Managing drug resistant tuberculosis [PDF]

BMJ, 2008
#### Summary points Antituberculosis drug resistance is increasing both in the United Kingdom and internationally.1 2 It has come to greater public attention with the emergence of extensively drug resistant tuberculosis (box 1) in South Africa, where an outbreak proved rapidly fatal among people with advanced HIV infection.3 In this article we review ...
Grant, Alison, Gothard, Philip, Thwaites, Guy   +2 more
openaire   +4 more sources

Drug resistance in tuberculosis [PDF]

European Respiratory Journal, 2005
A drug-resistant strain ofMycobacterium tuberculosisis defined as one differing from the tight distribution of wild strains that have not come into contact with the drug concerned.Sensitivity tests are performed by the absolute concentration method, the resistance ratio method or the proportion method. The hypothesis underlying the proportion method is
openaire   +2 more sources

Characterization of Mycobacterium tuberculosis strains in Beijing, China: drug susceptibility phenotypes and Beijing genotype family transmission

BMC Infectious Diseases, 2018
Background The most prevalent strains of Mycobacterium tuberculosis (M.tb) in Beijing belong to the Beijing genotype family. The influence of Beijing genotype prevalence on the development of drug resistance, and the association of infection with Beijing
Yi Liu, Xuxia Zhang, Yuqing Zhang, Yong Sun, Cong Yao, Wei Wang, Chuanyou Li   +6 more
doaj   +1 more source

Xpert MTB/RIF Ultra outperformed the Xpert assay in tuberculosis lymphadenitis diagnosis: a prospective head-to-head cohort study

International Journal of Infectious Diseases, 2022
Objectives: Xpert Mycobacterium tuberculosis/rifampin (MTB/RIF) Ultra (Xpert-Ultra) has shown better sensitivity in comparison with Xpert MTB/RIF (Xpert) in extrapulmonary tuberculosis (TB), whereas the head-to-head comparison of these methods in TB ...
Xia Yu, Tingting Zhang, Yaoyao Kong, Fen Wang, Lingling Dong, Ming Han, Hairong Huang   +6 more
doaj   +1 more source

Linezolid-containing regimens for the treatment of drug-resistant tuberculosis in South African children.

, 2012
BACKGROUND: Treatment options for drug-resistant tuberculosis (DR-TB) are limited. Linezolid has been successfully used to treat DR-TB in adults, but there are few case reports of its use in children for TB.
Rose, PC, Hallbauer, UM, Hesseling, AC, Schaaf, HS, Seddon, JA   +4 more
core   +1 more source