Current Concepts on Drug Abuse and Dependence [PDF]
, 2015 Drug addiction is a complex disease characterized by compulsive and uncontrollable desire to seek and consume the drug. In time, drug-related terminology has undergone many changes, arising from the deepening of the mechanisms of action, but also about ...
Baconi, Daniela Luiza +5 more
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Orphanet Journal of Rare Diseases, 2022 Background Aberrations to endoplasmic/sarcoplasmic reticulum (ER/SR) calcium concentration can result in the departure of endogenous proteins in a phenomenon termed exodosis.
Lacey K. Greer +3 more
doaj +1 more source
Nature Communications, 2022 The prefrontal cortex is involved in goal-directed behaviour. Here the authors show that medial prefrontal cortex activates goal-directed motivation and dopamine neurons via a feedback loop with the anteromedial thalamus.
Chen Yang +20 more
doaj +1 more source
Prediction of stress and drug craving ninety minutes in the future with passively collected GPS data
npj Digital Medicine, 2020 Just-in-time adaptive interventions (JITAIs), typically smartphone apps, learn to deliver therapeutic content when users need it. The challenge is to “push” content at algorithmically chosen moments without making users trigger it with effortful input ...
David H. Epstein +6 more
doaj +1 more source
Dopamine transients do not act as model-free prediction errors during associative learning
Nature Communications, 2020 Dopamine neurons are proposed to signal the reward prediction error in model-free reinforcement learning algorithms. Here, the authors show that when given during an associative learning task, optogenetic activation of dopamine neurons causes associative,
Melissa J. Sharpe +6 more
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ANALISIS YURIDIS SOSIOLOGIS PEMBINAAN NARAPIDANA PENYALAHGUNAAN NARKOTIKA UNTUK DIRI SENDIRI DI LEMBAGA PEMASYARAKATAN UMUM (Studi di Lembaga Permasyarakatan Kelas II A Kerobokan Badung Bali) [PDF]
, 2023 The issue of drug abuse in Indonesia is currently very concerning. Drug abuse is a very serious problem. Despite increased law enforcement efforts against drugs, drug trafficking continues to rise due to several factors, including inadequate ...
Riduan, Rizaldi
core
Public spending for illegal drug and alcohol treatment in hospitals: an EU cross-country comparison [PDF]
, 2014 Background: In view of the current economic crisis and the resulting austerity measures being implemented by governments across Europe, public expenditure for substance abuse treatment has increasingly become a subject of discussion.
Christiaens, Johan +2 more
core +3 more sources
Whole brain dynamics during optogenetic self-stimulation of the medial prefrontal cortex in mice
Communications Biology, 2021 Cover et al. develop a method that permits functional MRI of brain dynamics while mice are cued to perform an operant task: licking a spout to receive optogenetic stimulation to the medial prefrontal cortex.
Christopher G. Cover +6 more
doaj +1 more source
Trends and correlates of substance use disorders among probationers and parolees in the United States 2002–2014 [PDF]
, 2016 BACKGROUND: Substance use and crime/recidivism are irrevocably linked. We explore the nuances of this association by highlighting the prevalence, trends, and correlates of substance use dsorders in a large group of probationers/parolees.
DeLisi, Matt +5 more
core +1 more source
Frontiers in Neuroscience, 2015 Methylenedioxypyrovalerone (MDPV) is generally considered to be a more potent cocaine-like psychostimulant, as it shares a similar pharmacological profile with cocaine and induces similar physiological and locomotor responses.
Ken Taro Wakabayashi +2 more
doaj +1 more source