Results 101 to 110 of about 932,717 (306)

Drug Court Evaluation Documents Program's Success, Data Download, Iowa Department of Corrections, August 2009 [PDF]

, 2009
The Division of Criminal and Juvenile Justice Planning (CJJP) recently released its study of Iowa’s six adult drug courts, all of which are administered by community corrections agencies. Making heavy use of DOC’s ICON data base, CJJP examined completion

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p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

Governor's Office of Drug Control Policy Five-Year Strategic Plan, July 1, 2013-June 30, 2018 [PDF]

, 2014
The Office of the Drug Policy Coordinator is established in Chapter 80E of the Code of Iowa. The Coordinator directs the Governor’s Office of Drug Control Policy; coordinates and monitors all statewide counter-drug efforts, substance abuse treatment ...

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Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

Advanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu, Yuyu Wu, Yingjie Chen, Xiyi Chen, Xingjie Zan, Yanlong Liu, Wujun Geng   +6 more
wiley   +1 more source

Arrested Adults Awaiting Arraignment: Mental Health, Substance Abuse, and Criminal Justice Characteristics and Needs [PDF]

, 2003
This Study is one of the first to look at the mentally ill during the pre-arraignment process. The pre-arraignment process is an excellent place to identify individuals with mental health and substance abuse problems, to examine those problems, to ...
Broner, Nahama, Karopkin, Martin G., Lamon, Stacy S., Mayrl, Damon W.   +3 more
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Novel Vascularized Human Liver Organoids for Modeling Alcohol‐Induced Liver Injury and Developing Hepatoprotective Therapy

Advanced Science, EarlyView.
This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang, Xiayan Chu, Xuerui Wang, Wenkun Zhang, Jinnuo Lu, Chuting Xu, Shoucheng Hu, Guoyu Pan, Chih‐Tsung Yang, Xiaohui Zhang, Shaojin Li, Zhaobin Guo, Hanyang Liu, Guangbo Ge   +13 more
wiley   +1 more source

IMPACT OF THE GHRELIN SYSTEM ON OXYCODONE-MOTIVATED BEHAVIORS STUDIED IN WISTAR RATS: SEX DIFFERENCES AND THE EFFECTS OF GHRELIN RECEPTOR DELETION AND ANTAGONISM

IBRO Neuroscience Reports, 2023
Ansh Agarwal, Zhi-Bing You, Sruti Pari, Madeline Crissman, Guo-Hua Bi, Lorenzo Leggio, Eliot Gardner   +6 more
doaj   +1 more source

Faktor-Faktor Keluarga dan Tingkah Laku Penyalahgunaan Dadah: Satu Kajian Perbandingan antara Penyalahguna Dadah dengan Bukan Penyalahguna Dadah [PDF]

, 1993
The present study compares aspects of parent-child communication, parent-child nurturance, and family members involvement in drug abuse between drug abusers and non-drug abusers.
Al Hadi, H. M. Abdullah
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Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

GPR55 is expressed in glutamate neurons and functionally modulates drug taking and seeking in rats and mice

Translational Psychiatry
G protein-coupled receptor 55 (GPR55) has been thought to be a putative cannabinoid receptor. However, little is known about its functional role in cannabinoid action and substance use disorders.
Yi He, Hui Shen, Guo-Hua Bi, Hai-Ying Zhang, Omar Soler-Cedeño, Hannah Alton, Yihong Yang, Zheng-Xiong Xi   +7 more
doaj   +1 more source