Results 21 to 30 of about 932,717 (306)

Robust brain hyperglycemia during general anesthesia: relationships with metabolic brain inhibition and vasodilation

Frontiers in Physiology, 2016
Glucose is the main energetic substrate for the metabolic activity of brain cells and its proper delivery into the extracellular space is essential for maintaining normal neural functions.
R. Aaron eBola, Eugene A Kiyatkin
doaj   +1 more source

From clinical application to cognitive enhancement: the example of methylphenidate [PDF]

, 2016
Methylphenidate (MPD) is a central nervous system (CNS) stimulant, which belongs to the phenethylamine group and is mainly used in the treatment of attention deficit hyperactive disorder (ADHD).
Busardo', FRANCESCO PAOLO, Cipolloni, Luigi, Frati, Paola, Kyriakou, Chrystalla, Zaami, Simona   +4 more
core   +1 more source

Behavior-associated and post-consumption glucose entry into the nucleus accumbens extracellular space during glucose free-drinking in trained rats

Frontiers in Behavioral Neuroscience, 2015
Glucose is the primary energetic substrate for the metabolic activity of brain cells and its proper delivery from the arterial blood is essential for neural activity and normal brain functions.
Ken Taro Wakabayashi, Eugene A Kiyatkin
doaj   +1 more source

Cingulate circuits are associated with escalation of heroin use and naloxone-induced increases in heroin self-administration

Addiction Neuroscience, 2022
Opioid use disorder (OUD) is defined as a compulsion to seek and take opioids, loss of control over intake and the development of a negative emotional state when access to opioids is denied.
Scarlata MJ, Keeley RJ, Carmack SA, Tsai P-J, Vendruscolo JCM, Lu H, Koob GF, Vendruscolo LF, Stein EA   +8 more
doaj   +1 more source

Race/ethnicity and gender differences in drug use and abuse among college students [PDF]

, 2007
This study examines race/ethnicity and gender differences in drug use and abuse for substances other than alcohol among undergraduate college students.
Boyd, Carol J., Cranford, James A., Delva, Jorge, McCabe, Sean Esteban, McPherson, Melnee D., Morales, Michele   +5 more
core   +2 more sources

Language models in digital psychiatry: challenges with simplification of healthcare materials

NPP-Digital Psychiatry and Neuroscience
Linguistic hurdles in healthcare, such as complex language, significantly affect patient outcomes, including satisfaction with interaction, comprehension of healthcare materials, and engagement with the healthcare system.
Ankit Aich, Tingting Liu, Salvatore Giorgi, Kelsey Isman, Ruhshana Bobojonova, Lyle Ungar, Brenda Curtis   +6 more
doaj   +1 more source

Supramammillary neurons projecting to the septum regulate dopamine and motivation for environmental interaction in mice

Nature Communications, 2021
The supramammillary region (SuM) regulates arousal that reinforces and energizes behavioral interaction with the environment. Here the authors investigate how SuM neurons interact with medial septal neurons and ventral tegmental dopamine neurons to ...
Andrew J. Kesner, Rick Shin, Coleman B. Calva, Reuben F. Don, Sue Junn, Christian T. Potter, Leslie A. Ramsey, Ahmed F. Abou-Elnaga, Christopher G. Cover, Dong V. Wang, Hanbing Lu, Yihong Yang, Satoshi Ikemoto   +12 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Enhanced Survival of Dopaminergic Neuronal Transplants in Hemiparkinsonian Rats by the p53 Inactivator PFT-α

Cell Transplantation, 2011
A key limiting factor impacting the success of cell transplantation for Parkinson's disease is the survival of the grafted cells, which are often short lived.
J. Chou, N. H. Greig, D. Reiner, B. J. Hoffer, Y. Wang M.D., Ph.D.   +4 more
doaj   +1 more source

Machine learning classification of resting state functional connectivity predicts smoking status

Frontiers in Human Neuroscience, 2014
Machine learning-based approaches are now able to examine functional magnetic resonance imaging data in a multivariate manner and extract features predictive of group membership.
Vani ePariyadath, Elliot A Stein, Thomas J Ross   +2 more
doaj   +1 more source