Results 121 to 130 of about 4,201,815 (397)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Criminal Responsibility of the Addict: Conviction by Force of Habit [PDF]

, 1973
This article addresses questions of criminal responsibility of drug addicts in light of Robinson v. California, holding criminal sanctions for a status of drug addiction to be unconstitutional under the eighth amendment.
Diamond, Michael R.
core   +1 more source

Can disordered mobile phone use be considered a behavioral addiction? An update on current evidence and a comprehensive model for future research [PDF]

, 2015
Despite the many positive outcomes, excessive mobile phone use is now often associated with potentially harmful and/or disturbing behaviors (e.g., symptoms of deregulated use, negative impact on various aspects of daily life such as relationship problems,
A Bianchi, A Blaszczynski, A Ehrenberg, A Lepp, AE Goudriaan, AL Dir, ALS King, ALS King, Annemarie Nicol, BS Fjeldsoe, C Augner, CF Yen, CM Kokkinos, D Kim, DJ Stein, F Zheng, G Dong, H Blake, H Khang, J Billieux, J Billieux, J Billieux, J Billieux, J Billieux, J Billieux, J Weafer, J Weinstock, J-Y Mok, JA Roberts, JH Ha, JM Violanti, L Leung, M Chóliz, M Kwon, M Littel, M Salehan, M Toda, MD Griffiths, MD Griffiths, MP White, NM Petry, O Lopez-Fernandez, P Smetaniuk, RC Nickerson, RJ Holst Van, S Butt, S Thomée, SM Groman, T Igarashi, X Carbonell, X Lu, X Lu, Y Barkana, Y-H Lin, Y-K Lee, Z-H Zhou   +55 more
core   +1 more source

Integrated exercise program in opioid agonist therapy clinics and effect on psychological distress: study protocol for a randomized controlled trial (BAReAktiv)

Trials
Background Substance use disorder is associated with unhealthy lifestyle choices, resulting in adverse social and health consequences. People with opioid use disorder receiving opioid agonist therapy, in particular, have high morbidity and reduced ...
Einar Furulund, Tesfaye Madebo, Karl Trygve Druckrey-Fiskaaen, Jørn Henrik Vold, Mette Hegland Nordbotn, Eivin Dahl, Sindre M. Dyrstad, Torgeir Gilje Lid, Lars T. Fadnes, for the ATLAS4LAR study group   +9 more
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Tobacco exposure and alcohol drinking prevalence and associations with hypertension in rural southwest China: A cross-sectional study

Tobacco Induced Diseases
Introduction This study examined the prevalence of tobacco exposure and drinking and ascertained the relationships between tobacco exposure, alcohol drinking, concurrent smoking and drinking, and hypertension in rural southwestern China.
Guohui LI, Lan Liu, Du-li Liu, Zi-zi Yu, Allison R. Golden, Xiang-yang Yin*, Le Cai*   +6 more
doaj   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

NARCOTIC DRUG ADDICTION [PDF]

, 1920
EMIL J. PELLINI
openalex   +1 more source

The world of the drug addict

Revista Psicopatologia Fenomenológica Contemporânea, 2017
A dependência de drogas compromete a consciência intencional. Na consciência normal, observa-se uma intencionalidade fluida, sendo a realidade compartilhada o resultado pré-reflexivo óbvio desta situação. Sob o efeito da intoxicação por drogas, no entanto, perde-se esta estabilidade intencional e, consequentemente, padece-se de uma espécie de ...
openaire   +5 more sources

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source