Results 31 to 40 of about 7,897,516 (385)

Generic drug competition: The pharmaceutical industry “gaming” controversy [PDF]

, 2019
Among American adults 20 years and older, 59 percent take at least one prescription drug on a regular basis. Unlike most branded drugs, which are generally drugs that have a trade name and are protected by a patent, off‐patent generic drugs make up ...
Association for Accessible Medicines, Bloomberg Law, Brennan Z., Congressional Budget Office, Express Scripts, Federal Trade Commission, Federal Trade Commission, Federal Trade Commission, Gafney A., Kroh E., Noonan K. E., Sullivan T., Sullivan T., Sullivan T., Syrop J., U.S. Department of Health and Human Services, U.S. Food and Drug Administration, U.S. Food and Drug Administration, U.S. Food and Drug Administration, U.S. Food and Drug Administration, U.S. Food and Drug Administration, U.S. Food and Drug Administration, U.S. Food and Drug Administration, U.S. Food and Drug Administration, U.S. Food and Drug Administration, U.S. Food and Drug Administration, U.S. Food and Drug Administration, U.S. Government Accountability Office   +27 more
core   +1 more source

BRAF and MEK inhibitors differentially affect nivolumab-induced T cell activation by modulating the TCR and AKT signaling pathways

OncoImmunology, 2019
Immune checkpoint inhibitors (ICIs) such as the anti-PD-1 antibody Nivolumab, achieve remarkable clinical efficacy in patients with late stage cancers. However, only a small subset of patients benefit from this therapy.
Peng Yue, Taylor Harper, Silvia M. Bacot, Monica Chowdhury, Shiowjen Lee, Adovi Akue, Mark A. Kukuruga, Tao Wang, Gerald M. Feldman   +8 more
doaj   +1 more source

Evaluating the potential of gold, silver, and silica nanoparticles to saturate mononuclear phagocytic system tissues under repeat dosing conditions

Particle and Fibre Toxicology, 2017
Background As nanoparticles (NPs) become more prevalent in the pharmaceutical industry, questions have arisen from both industry and regulatory stakeholders about the long term effects of these materials. This study was designed to evaluate whether gold (
James L. Weaver, Grainne A. Tobin, Taylor Ingle, Simona Bancos, David Stevens, Rodney Rouse, Kristina E. Howard, David Goodwin, Alan Knapton, Xiaohong Li, Katherine Shea, Sharron Stewart, Lin Xu, Peter L. Goering, Qin Zhang, Paul C. Howard, Jessie Collins, Saeed Khan, Kidon Sung, Katherine M. Tyner   +19 more
doaj   +1 more source

The continued value of disk diffusion for assessing antimicrobial susceptibility in clinical laboratories: Report from the Clinical and Laboratory Standards Institute Methods Development and Standardization Working Group [PDF]

, 2018
Expedited pathways to antimicrobial agent approval by the U.S. Food and Drug Administration (FDA) have led to increased delays between drug approval and the availability of FDA-cleared antimicrobial susceptibility testing (AST) devices.
Burnham, Carey-Ann D, Ferrell, Andrea, Hsiung, Andre, Humphries, Romney M, Kircher, Susan, Krause, Kevin M, Malherbe, Rianna   +6 more
core   +2 more sources

The role of PD-L1 expression as a predictive biomarker: an analysis of all US Food and Drug Administration (FDA) approvals of immune checkpoint inhibitors

Journal of Immunotherapy for Cancer, 2019
The development of immune checkpoint inhibitors has changed the treatment paradigm for advanced cancers across many tumor types. Despite encouraging and sometimes durable responses in a subset of patients, most patients do not respond.
A. Davis, V. Patel
semanticscholar   +1 more source

Nasal Drug Delivery Systems: An Overview [PDF]

, 2015
Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades ...
Conway, Barbara R., Ghori, Muhammad U., Mahdi, Mohammed H., Smith, Alan M.   +3 more
core   +1 more source

Atezolizumab potentiates Tcell-mediated cytotoxicity and coordinates with FAK to suppress cell invasion and motility in PD-L1+ triple negative breast cancer cells

OncoImmunology, 2019
Immune check point inhibitors targeting programmed cell death protein-1 (PD-1) and its ligand (PD-L1) have shown clinical success in treatment of human malignancies.
Nishant Mohan, Salman Hosain, Jun Zhao, Yi Shen, Xiao Luo, Jiangsong Jiang, Yukinori Endo, Wen Jin Wu   +7 more
doaj   +1 more source

Modulation of innate immune mechanisms to enhance vaccine induced immunity: Role of co-inhibitory molecules

Frontiers in Immunology, 2016
No licensed human vaccines are currently available against any parasitic disease including leishmaniasis. Several anti-leishmanial vaccine formulations have been tested in various animal models including genetically modified live attenuated parasite ...
Sreenivas eGannavaram, Parna eBhattacharya, Nevien eIsmail, Amit eKaul, Rakesh eSingh, Hira eNakhasi   +5 more
doaj   +1 more source

Decoding kinase-adverse event associations for small molecule kinase inhibitors

Nature Communications, 2022
Small molecule kinase inhibitors (SMKIs) are being approved at a fast pace under expedited programs for anticancer treatment. Here, the authors employ a machine-learning model to examine the relationships between kinase targets and adverse events in the ...
Xiajing Gong, Meng Hu, Jinzhong Liu, Geoffrey Kim, James Xu, Amy McKee, Todd Palmby, R. Angelo de Claro, Liang Zhao   +8 more
doaj   +1 more source

Cocaine self-administration in the mouse: A low-cost, chronic catheter preparation [PDF]

, 2012
Intravenous drug self-administration is the most valid animal model of human addiction because it allows volitional titration of the drug in the blood based on an individual’s motivational state together with the pharmacokinetic properties of the ...
Brian Cadle, Donald Cooper, Donald Cooper, Matthew Pomrenze, Michael Baratta   +4 more
core   +3 more sources