Results 251 to 260 of about 422,254 (308)

Use of a Molecular Signature Response Classifier to Inform Treatment Selection Improves Clinical Disease Activity Among Patients with Rheumatoid Arthritis Initiating a Biologic or Targeted Synthetic Disease‐Modifying Antirheumatic Drug

Arthritis Care &Research, EarlyView.
Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD). Methods PrismRA incorporated 19 gene expression features and four clinical features to assess a patient's likelihood of
Fenglong Xie, Timothy Beukelman, Nicholas P. McCormick, Jeffrey R. Curtis   +3 more
wiley   +1 more source

Consumed by Abdominal Distention

Arthritis Care &Research, EarlyView.
Abimbola Fadairo‐Azinge, James Grenert, Brian Haas, Mary Margaretten   +3 more
wiley   +1 more source

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Liposomes as drug carriers

Life Sciences, 1977
Abstract The use of liposomes as drug carrying vehicles are summarized. Introduction of smaller doses, increased permeability, reduced toxicological and allergic effects and altered immunological responses are the advantages of the method. Experimental techniques for the preparation of drug containing liposomes and for their deliveries are surveyed ...
J H, Fendler, A, Romero
openaire   +2 more sources

Drug carriers for vascular drug delivery

IUBMB Life, 2011
AbstractThe currently used drug carriers for vascular drug delivery are reviewed. The human vascular system possesses unique physiological features that can be exploited for enhanced and effective targeted drug delivery. Although the thin layer of endothelial cells (EC) lines the interior surface of blood vessels forming an interface between ...
Erez, Koren, Vladimir P, Torchilin
openaire   +2 more sources

Site-Specific Drug Carriers

Engineering in Medicine, 1986
Site-specific drug carriers are required to exclusively deliver drug molecules to difficult targets within the body. They should do so in a form which protects the drug and host from one another. This contribution reviews the reasons for drug targeting, and describes some of the features required of two types of carrier system, i.e., particulates and ...
openaire   +2 more sources

Carrier Deformability in Drug Delivery

Current Pharmaceutical Design, 2016
Deformability is a key property of drug carriers used to increase the mass penetration across the skin without disrupting the lipid barrier. Highly deformable vesicles proved to be more effective than conventional liposomes in delivering drugs into and across the mammalian skin upon topical non occlusive application.
Morilla, María José, Romero, Eder Lilia   +1 more
openaire   +3 more sources

Polymeric microspheres as drug carriers

Biomaterials, 1988
The use of polymeric microsphere systems (including polypeptides) as vehicles for delivering drugs by a variety of routes is considered with particular reference to parenteral administration. Microsphere formulation is discussed with emphasis on the role of surface properties and how these can determine the fate of administered particles.
S S, Davis, L, Illum
openaire   +2 more sources

Albumin-Based Nanodevices as Drug Carriers

Current Pharmaceutical Design, 2016
Nanomedicine, the application of nanotechnology to medicine, is being increasingly used to improve and exploit the advantages of efficient drug delivery. Different nanodevices have been developed in recent years, among them protein-based nanoparticles which have gained considerable interest.
Loureiro, Ana Isabel Sá, Azóia, Nuno G., Gomes, Andreia C, Cavaco-Paulo, Artur   +3 more
openaire   +3 more sources

Driving forces for drug loading in drug carriers

Journal of Microencapsulation, 2015
The loading capacity of a drug carrier is determined essentially by intermolecular interactions between drugs and carrier materials. In this review, the process of drug loading is described in detail based on the differences in the driving force for drug incorporation, including hydrophobic interaction, electrostatic interaction, hydrogen bonding, Pi ...
Yang, Li, Li, Yang
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Peptide vectors as drug carriers

2003
During the last decade, several peptides have been described, such as SynB vectors [1] penetratin and Tat [2, 3] that allow the intracellular delivery of polar, biologically active compounds in vitro and in vivo [2, 4]. These peptides, belonging to various families, are heterogeneous in size (10 to 18 amino acids) and sequence (Tab. 1).
Jamal, Temsamani, Jean-Michel, Scherrmann   +1 more
openaire   +2 more sources