Results 71 to 80 of about 429,667 (356)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Frontiers in Oncology, 2018 Glioblastoma, the most common, aggressive brain tumor, ranks among the least curable cancers—owing to its strong tendency for intracranial dissemination, high proliferation potential, and inherent tumor resistance to radiation and chemotherapy.
Drazen Raucher +2 more
doaj +1 more source
Infectious Diseases Associated With Renal Homotransplantation: I. Incidence, Types, and Predisposing Factors [PDF]
, 1964 Infectious diseases occurred in 26 of 30 renal homotransplantation patients and contributed to eight of the 12 deaths in this series. There were 52 infections, 17 occurring before and 35 after transplantation.
Marchioro, TL +3 more
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
PharmaceuticsIn the 21st century, thanks to advances in biotechnology and developing pharmaceutical technology, significant progress is being made in effective drug design.
Fatih Ciftci +5 more
doaj +1 more source
Dual antibiotherapy of tuberculosis mediated by inhalable locust bean gum microparticles [PDF]
, 2017 Despite the existence of effective oral therapy, tuberculosis remains a deadly pathology, namely because of bacterial resistance and incompliance with treatments.
Alves, Ana D. +7 more
core +1 more source
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
Aerogels: Tailor-made Carriers for Immediate and Prolonged Drug Release
KONA Powder and Particle Journal, 2014 The potential of inorganic polymeric materials – silica aerogels – as tailor-made drug carriers is discussed. It is shown that the dissolution rate of poorly soluble drugs can be significantly changed through
Irina Smirnova +2 more
doaj +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Dendrimers: novel carriers for drug delivery
Journal of Applied Pharmaceutical Research, 2016 Dendrimers are highly branched, organic compounds with well-defined, symmetrical structure. From chemical point of view they are three-dimensional polymers, characterized by a globular shape. At the end of the arms are terminals, functional groups, which
H. S. Chaudhari +3 more
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