Overcoming the challenges of drug resistance through combination drug delivery approach [PDF]
, 2022 Anticancer and antimicrobial drug resistances are the most important problems that decrease the overall success of drug treatment in the clinic. The combination of two or more different kinds of drugs in clinical practice has been generally accepted as a
Tonbul, Hayrettin +2 more
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Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms : revival of an old drug [PDF]
, 2013 BACKGROUND: It is widely recognized that only a handful of drugs are available against soil-transmitted helminthiasis, all of which are characterized by a low efficacy against Trichuris trichiura, when administered as single doses.
Speich Benjamin +17 more
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AtriplaR/anti-TB Combination in TB/HIV Patients. Drug in Focus. [PDF]
, 2011 Co-administration of anti-tuberculosis and antiretroviral therapy is often inevitable in high-burden countries where tuberculosis is the most common opportunistic infection associated with HIV/AIDS. Concurrent use of rifampicin and several antiretroviral
Semvua Hadija H +5 more
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Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and -resistant Plasmodium falciparum strains [PDF]
, 2007 Piperaquine is being developed as a long-acting component in artemisinin combination therapies. It was highly active in vitro and drug interaction studies showed that dihydroartemisinin combinations with piperaquine, chloroquine, and amodiaquine were ...
Adagu, IS +5 more
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Deep Learning Based Anticancer Drug Combination Discovery Through Natural Compounds and Pharmaceutical Drugs [PDF]
, 2023 Drug combination therapies have shown effective performance in treating cancer through increased efficacy and circumvention of drug resistance through drug synergy.
Elton, Cao
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Systems analysis of drug-induced receptor tyrosine kinase reprogramming following targeted mono- and combination anti-cancer therapy [PDF]
, 2014 The receptor tyrosine kinases (RTKs) are key drivers of cancer progression and targets for drug therapy. A major challenge in anti-RTK treatment is the dependence of drug effectiveness on co-expression of multiple RTKs which defines resistance to single ...
Goltsov, Alexey +27 more
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The costs of introducing artemisinin-based combination therapy: evidence from district-wide implementation in rural Tanzania. [PDF]
, 2008 BACKGROUND\ud \ud The development of antimalarial drug resistance has led to increasing calls for the introduction of artemisinin-based combination therapy (ACT).
Goodman Catherine A +17 more
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Drug-drug combination map. [PDF]
, 2019 Fig 2 depicts the pairwise drug-drug combinations extracted from phase III and IV ovarian cancer clinical trials of the 43 drugs used in these combinations.
Michael Schwarz (209306) +7 more
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In vitro and in vivo efficacy of a Rift Valley fever virus vaccine based on pseudovirus
Human Vaccines & Immunotherapeutics, 2019 Rift Valley fever virus (RVFV), a recognized category A priority pathogen, causes large outbreaks of Rift Valley fever with some fatalities in humans in humans and huge economic losses in livestock.
Jian Ma +6 more
doaj +1 more source
Combination Phenobarbital/Antibiotic Drug Reactions
Pediatric Neurology Briefs, 1991 Undesirable drug reactions during simultaneous administration of high dosage phenobarbital and beta lactam antibiotics, mainly Cefotaxim, are reported in 24 of 49 children admitted to intensive care at the Klinikum der J W Goethe Universitat, Frankfort ...
J Gordon Millichap
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