Results 11 to 20 of about 1,374,488 (249)

SynergyFinder Plus: Toward Better Interpretation and Annotation of Drug Combination Screening Datasets

Genomics, Proteomics & Bioinformatics, 2022
Combinatorial therapies have been recently proposed to improve the efficacy of anticancer treatment. The SynergyFinder R package is a software used to analyze pre-clinical drug combination datasets.
Shuyu Zheng, Wenyu Wang, Jehad Aldahdooh, Alina Malyutina, Tolou Shadbahr, Ziaurrehman Tanoli, Alberto Pessia, Jing Tang   +7 more
doaj   +3 more sources

Improving synergistic drug combination prediction with signature-based gene expression features in oncology [PDF]

Frontiers in Pharmacology
BackgroundCombination therapies play a crucial role in the treatment of complex diseases, such as cancer. They enhance efficacy, minimize resistance, and reduce toxicity by leveraging synergistic effects.
Mozhgan Mozaffarilegha, Sajjad Gharaghani   +1 more
doaj   +2 more sources

Novel Developments to Enable Treatment of CNS Diseases with Targeted Drug Delivery

Pharmaceutics, 2023
The blood-brain barrier (BBB) is a major hurdle for the development of systemically delivered drugs against diseases of the central nervous system (CNS).
Axel H. Meyer, Thomas M. Feldsien, Mario Mezler, Christopher Untucht, Ramakrishna Venugopalan, Didier R. Lefebvre   +5 more
doaj   +1 more source

Synergy Assessment of Four Antimicrobial Bioactive Compounds for the Combinational Treatment of Bacterial Pathogens

Biomedicines, 2023
Antimicrobial resistance (AMR) has become a topic of great concern in recent years, with much effort being committed to developing alternative treatments for resistant bacterial pathogens.
Kevin Masterson, Ian Major, Mark Lynch, Neil Rowan   +3 more
doaj   +1 more source

Radius additivity score: a novel combination index for tumour growth inhibition in fixed-dose xenograft studies

Frontiers in Pharmacology, 2023
The effect of combination therapies in many cancers has often been shown to be superior to that of monotherapies. This success is commonly attributed to drug synergies.
Nicola Melillo, Jake Dickinson, Lu Tan, Hitesh B. Mistry, Hitesh B. Mistry, Heinrich J. Huber   +5 more
doaj   +1 more source

Immunogenicity of influenza vaccine in elderly people: a systematic review and meta-analysis of randomized controlled trials, and its association with real-world effectiveness

Human Vaccines & Immunotherapeutics, 2020
Background: Older people (≥60 years old) are particularly vulnerable to influenza virus infection, and vaccine is effective in reducing the disease burden in this population. However, it remains obscure whether their antibody response is lower than those
Ziyan Meng, Jiayou Zhang, Jinrong Shi, Wei Zhao, Xiaoyuan Huang, Li Cheng, Xiaoming Yang   +6 more
doaj   +1 more source

New Insight into Breast Cancer Cells Involving Drug Combinations for Dopamine and Serotonin Receptors

Applied Sciences, 2021
The breast cancer therapies available are insufficient, especially since first-line treatments, such as paclitaxel, result in drug resistance and their toxicity often limits their concentration.
Bárbara Costa, Rita Matos, Irina Amorim, Fátima Gärtner, Nuno Vale   +4 more
doaj   +1 more source

Single-Fluorescence ATP Sensor Based on Fluorescence Resonance Energy Transfer Reveals Role of Antibiotic-Induced ATP Perturbation in Mycobacterial Killing

mSystems, 2022
The rapid emergence of multidrug-resistant/extensively drug-resistant tuberculosis (TB) is responsible for treatment failure in patients with TB and significantly endangers global public health.
Lujie Liang, Daixi Lin, Yishen Chen, Jiachen Li, Wanfei Liang, Hui Zhao, Wenji Luo, Guo-bao Tian, Siyuan Feng   +8 more
doaj   +1 more source

Liposomes Co-Encapsulating Cisplatin/Mifepristone Improve the Effect on Cervical Cancer: In Vitro and In Vivo Assessment

Pharmaceutics, 2020
Cervical cancer is usually diagnosed in the later stages despite many campaigns for early detection and continues to be a major public health problem. The standard treatment is cisplatin-based chemotherapy plus radiotherapy, but patient response is far ...
Fabricio Ledezma-Gallegos, Rafael Jurado, Roser Mir, Luis Alberto Medina, Laura Mondragon-Fuentes, Patricia Garcia-Lopez   +5 more
doaj   +1 more source

An herbal drug combination identified by knowledge graph alleviates the clinical symptoms of plasma cell mastitis patients: A nonrandomized controlled trial

eLife, 2023
Background: Plasma cell mastitis (PCM) is a nonbacterial breast inflammation with severe and intense clinical manifestation, yet treatment methods for PCM are still rather limited. Although the mechanism of PCM remains unclear, mounting evidence suggests
Caigang Liu, Hong Yu, Guanglei Chen, Qichao Yang, Zichu Wang, Nan Niu, Ling Han, Dongyu Zhao, Manji Wang, Yuanyuan Liu, Yongliang Yang   +10 more
doaj   +1 more source