Results 11 to 20 of about 5,698,960 (306)

Overcoming the challenges of drug resistance through combination drug delivery approach

, 2022
Anticancer and antimicrobial drug resistances are the most important problems that decrease the overall success of drug treatment in the clinic. The combination of two or more different kinds of drugs in clinical practice has been generally accepted as a
Tonbul, Hayrettin, Çapan, Yılmaz, Şahin, Adem, Tonbul H., Şahin A., Çapan Y., ÇAPAN, YILMAZ   +6 more
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Deep Learning Based Anticancer Drug Combination Discovery Through Natural Compounds and Pharmaceutical Drugs [PDF]

, 2023
Drug combination therapies have shown effective performance in treating cancer through increased efficacy and circumvention of drug resistance through drug synergy.
Elton, Cao
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Nanocarrier-based drug combination therapy for glioblastoma. [PDF]

, 2020
The current achievements in treating glioblastoma (GBM) patients are not sufficient because many challenges exist, such as tumor heterogeneity, the blood brain barrier, glioma stem cells, drug efflux pumps and DNA damage repair mechanisms.
Zhao, Mengnan, Schiffelers, Raymond M., Zhao, M.N., Broekman, Marike L. D., Broekman, M.L.D., van Straten, Demian, Straten, D. van, Schiffelers, R.M., Broekman, Marike L D, Preat, V., Préat, Véronique, Schiffelers, Raymond M, CDL Staf Research, Circulatory Health, CDL Cluster Onderzoek en Onderwijs, Cancer   +15 more
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The recent progress of deep-learning-based in silico prediction of drug combination

, 2023
Drug combination therapy has become a common strategy for the treatment of complex diseases. There is an urgent need for computational methods to efficiently identify appropriate drug combinations owing to the high cost of experimental screening.
Liu, H, Haoyang Liu, Ran, T, Yuedong Yang, Yang, Y, Ting Ran, Hongming Chen, Chen, H, Zhiguang Fan, Jie Lin, Fan, Z, Lin, J   +11 more
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Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms : revival of an old drug [PDF]

, 2013
BACKGROUND: It is widely recognized that only a handful of drugs are available against soil-transmitted helminthiasis, all of which are characterized by a low efficacy against Trichuris trichiura, when administered as single doses.
Speich Benjamin, Tritten Lucienne, Jennifer Keiser, Speich, B., Keiser Jennifer, Benjamin Speich, Adelfio Roberto, Keiser, J., Adelfio, R., Tritten, L., Silbereisen Angelika, Vargas Mireille, Angelika Silbereisen, Roberto Adelfio, Silbereisen, A., Vargas, M., Lucienne Tritten, Mireille Vargas, Speich B, Keiser J, Tritten L, Adelfio R, Silbereisen A, Vargas M   +23 more
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Systems analysis of drug-induced receptor tyrosine kinase reprogramming following targeted mono- and combination anti-cancer therapy [PDF]

, 2014
The receptor tyrosine kinases (RTKs) are key drivers of cancer progression and targets for drug therapy. A major challenge in anti-RTK treatment is the dependence of drug effectiveness on co-expression of multiple RTKs which defines resistance to single ...
Goltsov, Alexey, Stylianos Kyriakidis, Hilal Khalil, Simon P. Langdon, Harrison, David James, Langdon, Simon P., Bown, James L., Khalil, Hilal S., Simon Langdon, Tero Soininen, Khalil, Hilal S, Soininen, Tero, Alexey Goltsov, Huizhong Hu, David J. Harrison, Bown, James, David Harrison, Deeni, Yusuf, Harrison, David J, Kyriakidis, Stylianos, Hu, Huizhong, Deeni, Yusuf Y.; id_orcid, Yusuf Deeni, Hilal S. Khalil, Langdon, Simon P, James Bown, Harrison, David J., Harrison, David James; id_orcid   +27 more
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The costs of introducing artemisinin-based combination therapy: evidence from district-wide implementation in rural Tanzania. [PDF]

, 2008
BACKGROUND\ud \ud The development of antimalarial drug resistance has led to increasing calls for the introduction of artemisinin-based combination therapy (ACT).
Goodman Catherine A, Mulligan Jo, Abdulla, Salim, Bloland, Peter, McHomvu, Naiman, Mills, Anne, Mills Anne, Mchomvu Naiman, Munkondya John S, Njau Joseph D, Abdulla Salim, Munkondya, John S, Bloland Peter, Kachur, S Patrick, Njau, Joseph D, Goodman, Catherine A, Kachur S Patrick, Mulligan, Jo   +17 more
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Looking beyond the cancer cell for effective drug combinations

Genome Medicine, 2016
Combinations of therapies are being actively pursued to expand therapeutic options and deal with cancer’s pervasive resistance to treatment. Research efforts to discover effective combination treatments have focused on drugs targeting intracellular ...
Jonathan R. Dry, Mi Yang, Julio Saez-Rodriguez   +2 more
doaj   +1 more source

Rational deployment of antimalarial drugs in Africa: should first-line combination drugs be reserved for paediatric malaria cases? [PDF]

, 2011
Artemisinin-based combination therapy is exerting novel selective pressure upon populations of Plasmodium falciparum across Africa. Levels of resistance to non-artemisinin partner drugs differ among parasite populations, and so the artemisinins are not ...
Mackinnon, Margaret J, COLIN J. SUTHERLAND, MARGARET J. MACKINNON, Babiker, H., MacKinnon, M.J., HAMZA BABIKER, Sutherland, Colin J, Ranford-Cartwright, Lisa, El Sayed, Badria Babiker, Sayed, B.B., Sutherland, C.J., Ranford-Cartwright, L.C., LISA RANFORD-CARTWRIGHT, BADRIA BABIKER EL SAYED, Babiker, Hamza   +14 more
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A drug combination prediction framework based on graph convolutional network and heterogeneous information

, 2022
Combination therapy, which can improve therapeutic efficacy and reduce side effects, plays an important role in the treatment of complex diseases. Yet, a large number of possible combinations among candidate compounds limits our ability to identify ...
Rao, Y, Lu, Y, Yang, Y, Chen, H
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