Results 31 to 40 of about 13,132,513 (343)

Liposomes Co-Encapsulating Cisplatin/Mifepristone Improve the Effect on Cervical Cancer: In Vitro and In Vivo Assessment

Pharmaceutics, 2020
Cervical cancer is usually diagnosed in the later stages despite many campaigns for early detection and continues to be a major public health problem. The standard treatment is cisplatin-based chemotherapy plus radiotherapy, but patient response is far ...
Fabricio Ledezma-Gallegos, Rafael Jurado, Roser Mir, Luis Alberto Medina, Laura Mondragon-Fuentes, Patricia Garcia-Lopez   +5 more
doaj   +1 more source

An herbal drug combination identified by knowledge graph alleviates the clinical symptoms of plasma cell mastitis patients: A nonrandomized controlled trial

eLife, 2023
Background: Plasma cell mastitis (PCM) is a nonbacterial breast inflammation with severe and intense clinical manifestation, yet treatment methods for PCM are still rather limited. Although the mechanism of PCM remains unclear, mounting evidence suggests
Caigang Liu, Hong Yu, Guanglei Chen, Qichao Yang, Zichu Wang, Nan Niu, Ling Han, Dongyu Zhao, Manji Wang, Yuanyuan Liu, Yongliang Yang   +10 more
doaj   +1 more source

The costs of introducing artemisinin-based combination therapy: evidence from district-wide implementation in rural Tanzania. [PDF]

, 2008
BACKGROUND\ud \ud The development of antimalarial drug resistance has led to increasing calls for the introduction of artemisinin-based combination therapy (ACT).
Goodman Catherine A, Mulligan Jo, Abdulla, Salim, Bloland, Peter, McHomvu, Naiman, Mills, Anne, Mills Anne, Mchomvu Naiman, Munkondya John S, Njau Joseph D, Abdulla Salim, Munkondya, John S, Bloland Peter, Kachur, S Patrick, Njau, Joseph D, Goodman, Catherine A, Kachur S Patrick, Mulligan, Jo   +17 more
core   +1 more source

In vitro and in vivo efficacy of a Rift Valley fever virus vaccine based on pseudovirus

Human Vaccines & Immunotherapeutics, 2019
Rift Valley fever virus (RVFV), a recognized category A priority pathogen, causes large outbreaks of Rift Valley fever with some fatalities in humans in humans and huge economic losses in livestock.
Jian Ma, Ruifeng Chen, Weijin Huang, Jianhui Nie, Qiang Liu, Youchun Wang, Xiaoming Yang   +6 more
doaj   +1 more source

Combination Phenobarbital/Antibiotic Drug Reactions

Pediatric Neurology Briefs, 1991
Undesirable drug reactions during simultaneous administration of high dosage phenobarbital and beta lactam antibiotics, mainly Cefotaxim, are reported in 24 of 49 children admitted to intensive care at the Klinikum der J W Goethe Universitat, Frankfort ...
J Gordon Millichap
doaj   +1 more source

Looking beyond the cancer cell for effective drug combinations

Genome Medicine, 2016
Combinations of therapies are being actively pursued to expand therapeutic options and deal with cancer’s pervasive resistance to treatment. Research efforts to discover effective combination treatments have focused on drugs targeting intracellular ...
Jonathan R. Dry, Mi Yang, Julio Saez-Rodriguez   +2 more
doaj   +1 more source

NEXGB: A Network Embedding Framework for Anticancer Drug Combination Prediction

International Journal of Molecular Sciences, 2022
Compared to single-drug therapy, drug combinations have shown great potential in cancer treatment. Most of the current methods employ genomic data and chemical information to construct drug–cancer cell line features, but there is still a need to explore ...
Fanjie Meng, Feng Li, Jinxing Liu, J. Shang, Xi-Kui Liu, Yan Li   +5 more
semanticscholar   +1 more source

Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies. [PDF]

, 2008
BACKGROUND: Most malaria-endemic countries are implementing a change in anti-malarial drug policy to artemisinin-based combination therapy (ACT). The impact of different drug choices and implementation strategies is uncertain.
Hastings, Ian M, Day, Nicholas PJ, White, Nicholas J., Dondorp, AM, Hastings, Ian M., Dondorp, Arjen M, Dondorp, Adrianus, Hastings, Ian, Day, Nicholas P. J., Pongtavornpinyo, W, Hastings, IM, Pongtavornpinyo, Wirichada, White, Nicholas J, Day, Nicholas, Day, Nicholas P.J., Yeung, Shunmay, Day, NP, White, NJ, White, Nicholas, Dondorp, Arjen M., Yeung, S, Hastings Ian M, Dondorp Arjen M, Pongtavornpinyo Wirichada, Day Nicholas PJ, Yeung Shunmay, White Nicholas J   +26 more
core   +1 more source

Eradication of Staphylococcus aureus Biofilm Infection by Persister Drug Combination

Antibiotics, 2022
Staphylococcus aureus can cause a variety of infections, including persistent biofilm infections, which are difficult to eradicate with current antibiotic treatments.
R. Yee, Yuting Yuan, Andreina Tarff, Cory Brayton, N. Gour, Jie Feng, Y. Zhang   +6 more
semanticscholar   +1 more source

Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations [PDF]

, 2014
This work was supported by grants from Breakthrough Breast Cancer and Scottish Funding Council (SRDG), and personal support to Alexey Goltsov from Scottish Informatics and Computer Science Alliance (SICSA) and to James Bown from The Northwood Trust.Drug ...
Bown, James, Goltsov, Alexey, Gregory Goltsov, Harrison, David J, Bown, J., Goltsov, Gregory, Simon P. Langdon, James eBown, Langdon, Simon P., Bown, James L., Langdon, S.P., Goltsov, G., Alexey eGoltsov, David eHarrison, Gregory eGoltsov, Alexey Goltsov, Harrison, D.J., Goltsov, A., Langdon, Simon P, David J. Harrison, Simon eLangdon, James Bown, Harrison, David J.   +22 more
core   +1 more source