Results 21 to 30 of about 1,374,488 (249)
In vitro and in vivo efficacy of a Rift Valley fever virus vaccine based on pseudovirus
Human Vaccines & Immunotherapeutics, 2019 Rift Valley fever virus (RVFV), a recognized category A priority pathogen, causes large outbreaks of Rift Valley fever with some fatalities in humans in humans and huge economic losses in livestock.
Jian Ma +6 more
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Combination Phenobarbital/Antibiotic Drug Reactions
Pediatric Neurology Briefs, 1991 Undesirable drug reactions during simultaneous administration of high dosage phenobarbital and beta lactam antibiotics, mainly Cefotaxim, are reported in 24 of 49 children admitted to intensive care at the Klinikum der J W Goethe Universitat, Frankfort ...
J Gordon Millichap
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Combinations of drugs in the Treatment of Obesity [PDF]
Pharmaceuticals, 2010 Obesity is a chronic disease associated with excess morbidity and mortality. Clinical treatment, however, currently offers disappointing results, with very high rates of weight loss failure or weight regain cycles, and only two drugs (orlistat and sibutramine) approved for long-term use.
Marcio C. Mancini +6 more
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Looking beyond the cancer cell for effective drug combinations
Genome Medicine, 2016 Combinations of therapies are being actively pursued to expand therapeutic options and deal with cancer’s pervasive resistance to treatment. Research efforts to discover effective combination treatments have focused on drugs targeting intracellular ...
Jonathan R. Dry +2 more
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DCDB: Drug combination database [PDF]
Bioinformatics, 2009 Abstract Summary: Rapid advances in pharmaceutical sciences have brought ever-increasing interests in combined therapies for better clinical efficacy and safety, especially in cases of complicated and refractory diseases. Innovative experimental technologies and theoretical frameworks are being actively developed for multicomponent drug ...
Yanbin Liu +3 more
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Search for Synergistic Drug Combinations to Treat Chronic Lymphocytic Leukemia
Cells, 2022 Finding synergistic drug combinations is an important area of cancer research. Here, we sought to rationally design synergistic drug combinations with an inhibitor of BTK kinase, ibrutinib, which is used for the treatment of several types of leukemia. We
Eleonora Ela Hezkiy +10 more
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Preclinical Studies and Drug Combination of Low-Cost Molecules for Chagas Disease
Pharmaceuticals, 2022 Chagas disease is caused by the protozoan Trypanosoma cruzi (T. cruzi). It remains the major parasitic disease in Latin America and is spreading worldwide, affecting over 10 million people. Hundreds of new compounds with trypanosomicidal action have been
Elena Aguilera +16 more
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Fish Capsules: A System for High‐Throughput Screening of Combinatorial Drugs
Advanced Science, 2022 Large‐scale screening of molecules heavily relies on phenotyping of small living organisms during preclinical development. However, deep profiling candidate therapeutics on whole animals typically requires laborious manipulations and anesthetic treatment
Minghui Tang +10 more
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Frontiers in Psychiatry, 2022 Opioids and stimulants are often used in combination for both recreational and non-recreational purposes. High-efficacy mu opioid agonists generally increase the behavioral effects of stimulants, whereas opioid receptor antagonists generally attenuate ...
Mark A. Smith +16 more
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Frontiers in Oncology, 2021 PurposeThis study aims to inform previous clinical assessments to better understand the total risk of hypertension with atezolizumab and bevacizumab (hereafter referred to as “A-B”) in cancer patients, and reduce future incidence of hypertension-related ...
Linhan Jiang +5 more
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