Results 21 to 30 of about 13,132,513 (343)

New Insight into Breast Cancer Cells Involving Drug Combinations for Dopamine and Serotonin Receptors

Applied Sciences, 2021
The breast cancer therapies available are insufficient, especially since first-line treatments, such as paclitaxel, result in drug resistance and their toxicity often limits their concentration.
Bárbara Costa, Rita Matos, Irina Amorim, Fátima Gärtner, Nuno Vale   +4 more
doaj   +1 more source

Comparative analysis of molecular fingerprints in prediction of drug combination effects

Briefings Bioinform., 2021
Application of machine and deep learning methods in drug discovery and cancer research has gained a considerable amount of attention in the past years.
B. Zagidullin, Ziyan Wang, Yuanfang Guan, E. Pitkänen, Jing Tang   +4 more
semanticscholar   +1 more source

Overcoming the challenges of drug resistance through combination drug delivery approach

, 2022
Anticancer and antimicrobial drug resistances are the most important problems that decrease the overall success of drug treatment in the clinic. The combination of two or more different kinds of drugs in clinical practice has been generally accepted as a
Tonbul, Hayrettin, Çapan, Yılmaz, Şahin, Adem   +2 more
core   +1 more source

AtriplaR/anti-TB Combination in TB/HIV Patients. Drug in Focus. [PDF]

, 2011
Co-administration of anti-tuberculosis and antiretroviral therapy is often inevitable in high-burden countries where tuberculosis is the most common opportunistic infection associated with HIV/AIDS. Concurrent use of rifampicin and several antiretroviral
Semvua Hadija H, Kibiki, Gibson S, Hadija H Semvua, Gibson S Kibiki, Semvua, Hadija H, Kibiki Gibson S   +5 more
core   +1 more source

Drug combination therapy for emerging viral diseases

Drug Discovery Today, 2021
Effective therapeutics to combat emerging viral infections are an unmet need. Historically, treatments for chronic viral infections with single drugs have not been successful, as exemplified by human immunodeficiency virus (HIV) and hepatitis C virus ...
Zeenat A. Shyr, Yu-Shan Cheng, Donald C. Lo, Wei Zheng   +3 more
semanticscholar   +1 more source

Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms : revival of an old drug [PDF]

, 2013
BACKGROUND: It is widely recognized that only a handful of drugs are available against soil-transmitted helminthiasis, all of which are characterized by a low efficacy against Trichuris trichiura, when administered as single doses.
Speich Benjamin, Tritten Lucienne, Jennifer Keiser, Speich, B., Keiser Jennifer, Benjamin Speich, Adelfio Roberto, Keiser, J., Adelfio, R., Tritten, L., Silbereisen Angelika, Vargas Mireille, Angelika Silbereisen, Roberto Adelfio, Silbereisen, A., Vargas, M., Lucienne Tritten, Mireille Vargas   +17 more
core   +2 more sources

Rational drug combination design in patient-derived avatars reveals effective inhibition of hepatocellular carcinoma with proteasome and CDK inhibitors

Journal of experimental & clinical cancer research : CR, 2022
Background Hepatocellular carcinoma (HCC) remains difficult to treat due to limited effective treatment options. While the proteasome inhibitor bortezomib has shown promising preclinical activity in HCC, clinical trials of bortezomib showed no advantage ...
J. Lim, L. Hooi, Y. Dan, G. Bonney, Lei Zhou, P. Chow, C. Chee, T. Toh, E. Chow   +8 more
semanticscholar   +1 more source

Single-Fluorescence ATP Sensor Based on Fluorescence Resonance Energy Transfer Reveals Role of Antibiotic-Induced ATP Perturbation in Mycobacterial Killing

mSystems, 2022
The rapid emergence of multidrug-resistant/extensively drug-resistant tuberculosis (TB) is responsible for treatment failure in patients with TB and significantly endangers global public health.
Lujie Liang, Daixi Lin, Yishen Chen, Jiachen Li, Wanfei Liang, Hui Zhao, Wenji Luo, Guo-bao Tian, Siyuan Feng   +8 more
doaj   +1 more source

CDCDB: A large and continuously updated drug combination database

Scientific Data, 2022
In recent years, due to the complementary action of drug combinations over mono-therapy, the multiple-drugs for multiple-targets paradigm has received increased attention to treat bacterial infections and complex diseases.
Guy Shtar, L. Azulay, Omer Nizri, L. Rokach, Bracha Shapira   +4 more
semanticscholar   +1 more source

Systems analysis of drug-induced receptor tyrosine kinase reprogramming following targeted mono- and combination anti-cancer therapy [PDF]

, 2014
The receptor tyrosine kinases (RTKs) are key drivers of cancer progression and targets for drug therapy. A major challenge in anti-RTK treatment is the dependence of drug effectiveness on co-expression of multiple RTKs which defines resistance to single ...
Goltsov, Alexey, Stylianos Kyriakidis, Hilal Khalil, Simon P. Langdon, Harrison, David James, Langdon, Simon P., Bown, James L., Khalil, Hilal S., Simon Langdon, Tero Soininen, Khalil, Hilal S, Soininen, Tero, Alexey Goltsov, Huizhong Hu, David J. Harrison, Bown, James, David Harrison, Deeni, Yusuf, Harrison, David J, Kyriakidis, Stylianos, Hu, Huizhong, Deeni, Yusuf Y.; id_orcid, Yusuf Deeni, Hilal S. Khalil, Langdon, Simon P, James Bown, Harrison, David J.   +26 more
core   +1 more source