Results 21 to 30 of about 5,698,960 (306)

Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies. [PDF]

, 2008
BACKGROUND: Most malaria-endemic countries are implementing a change in anti-malarial drug policy to artemisinin-based combination therapy (ACT). The impact of different drug choices and implementation strategies is uncertain.
Hastings, Ian M, Day, Nicholas PJ, White, Nicholas J., Dondorp, Arjen M, Dondorp, Adrianus, Hastings, Ian, Pongtavornpinyo, W, Hastings, IM, Pongtavornpinyo, Wirichada, White, Nicholas J, Day, Nicholas, Day, Nicholas P.J., Yeung, Shunmay, White, Nicholas, Dondorp, Arjen M., Yeung, S, Hastings Ian M, Dondorp Arjen M, Pongtavornpinyo Wirichada, Day Nicholas PJ, Yeung Shunmay, White Nicholas J   +21 more
core   +1 more source

Search for Synergistic Drug Combinations to Treat Chronic Lymphocytic Leukemia

Cells, 2022
Finding synergistic drug combinations is an important area of cancer research. Here, we sought to rationally design synergistic drug combinations with an inhibitor of BTK kinase, ibrutinib, which is used for the treatment of several types of leukemia. We
Eleonora Ela Hezkiy, Santosh Kumar, Valid Gahramanov, Julia Yaglom, Arkadi Hesin, Suchita Suryakant Jadhav, Ekaterina Guzev, Shivani Patel, Elena Avinery, Michael A. Firer, Michael Y. Sherman   +10 more
doaj   +1 more source

Preclinical Studies and Drug Combination of Low-Cost Molecules for Chagas Disease

Pharmaceuticals, 2022
Chagas disease is caused by the protozoan Trypanosoma cruzi (T. cruzi). It remains the major parasitic disease in Latin America and is spreading worldwide, affecting over 10 million people. Hundreds of new compounds with trypanosomicidal action have been
Elena Aguilera, Carina Sánchez, María Eugenia Cruces, Belén Dávila, Lucía Minini, Florencia Mosquillo, Leticia Pérez-Díaz, Elva Serna, Susana Torres, Alicia Schini, Luis Sanabria, Ninfa I. Vera de Bilbao, Gloria Yaluff, Flavio R. Zolessi, Luis Fabian Ceilas, Hugo Cerecetto, Guzmán Alvarez   +16 more
doaj   +1 more source

Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations [PDF]

, 2014
This work was supported by grants from Breakthrough Breast Cancer and Scottish Funding Council (SRDG), and personal support to Alexey Goltsov from Scottish Informatics and Computer Science Alliance (SICSA) and to James Bown from The Northwood Trust.Drug ...
Bown, James, Goltsov, Alexey, Gregory Goltsov, Harrison, David J, Bown, J., Goltsov, Gregory, Simon P. Langdon, James eBown, Langdon, Simon P., Bown, James L., Langdon, S.P., Goltsov, G., Alexey eGoltsov, David eHarrison, Gregory eGoltsov, Alexey Goltsov, Harrison, D.J., Goltsov, A., Langdon, Simon P, David J. Harrison, Simon eLangdon, James Bown, Harrison, David J., Harrison, D.J.; id_orcid   +23 more
core   +1 more source

Fish Capsules: A System for High‐Throughput Screening of Combinatorial Drugs

Advanced Science, 2022
Large‐scale screening of molecules heavily relies on phenotyping of small living organisms during preclinical development. However, deep profiling candidate therapeutics on whole animals typically requires laborious manipulations and anesthetic treatment
Minghui Tang, Xin Duan, Anqi Yang, Shijie He, Yajing Zhou, Yuxin Liu, Lu Zhang, Xuan Luo, Peng Shi, Honglin Li, Xudong Lin   +10 more
doaj   +1 more source

Interactions Between Opioids and Dextroamphetamine on Locomotor Activity: Influence of an Opioid's Relative Efficacy at the Mu Receptor

Frontiers in Psychiatry, 2022
Opioids and stimulants are often used in combination for both recreational and non-recreational purposes. High-efficacy mu opioid agonists generally increase the behavioral effects of stimulants, whereas opioid receptor antagonists generally attenuate ...
Mark A. Smith, Shannon L. Ballard, Clarise F. Ballesteros, Samantha A. Bonge, Alexander T. Casimir, Lauren M. Childs, Max A. Feinstein, Annie K. Griffith, Alexandra N. Johansen, Daegeon Lee, A. Caroline Mauser, Cassidy M. Moses, Ian J. Robertson, Javier U. Robles, Justin C. Strickland, Mary E. Walters, Seeley J. Yoo   +16 more
doaj   +1 more source

DCDB: Drug combination database [PDF]

Bioinformatics, 2009
Abstract Summary: Rapid advances in pharmaceutical sciences have brought ever-increasing interests in combined therapies for better clinical efficacy and safety, especially in cases of complicated and refractory diseases. Innovative experimental technologies and theoretical frameworks are being actively developed for multicomponent drug ...
Yanbin Liu, Bin Hu, Chengxin Fu, Xin Chen   +3 more
openaire   +3 more sources

Combinations of drugs in the Treatment of Obesity [PDF]

Pharmaceuticals, 2010
Obesity is a chronic disease associated with excess morbidity and mortality. Clinical treatment, however, currently offers disappointing results, with very high rates of weight loss failure or weight regain cycles, and only two drugs (orlistat and sibutramine) approved for long-term use.
Halpern, Bruno, Oliveira, Eduardo S. L., Faria, André M., Halpern, Alfredo, Melo, Maria Edna de, Cercato, Cintia, Mancini, Marcio C.   +6 more
openaire   +3 more sources

Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and -resistant Plasmodium falciparum strains

, 2007
Piperaquine is being developed as a long-acting component in artemisinin combination therapies. It was highly active in vitro and drug interaction studies showed that dihydroartemisinin combinations with piperaquine, chloroquine, and amodiaquine were ...
Adagu, IS, Warhurst, David C, Fivelman, Quinton L, Fivelman, QL, Adagu, Ipemida S, Warhurst, DC   +5 more
core   +1 more source

Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. [PDF]

, 2005
BACKGROUND: Drug resistance in Plasmodium falciparum poses a major threat to malaria control. Combination antimalarial therapy including artemisinins has been advocated recently to improve efficacy and limit the spread of resistance, but artemisinins are
Albert Kilian, Sarah G Staedke (18026), Grant Dorsey, Yeka Adoke, Dorsey Grant, Kilian Albert, Kristin Banek (18020), Rosenthal Philip J, Grant Dorsey (18025), Moses R Kamya (18018), Reingold, Arthur, Nathan Bakyaita, Banek, Kristin, Staedke, Sarah G, Rosenthal, Philip J., Arthur Reingold (275222), Philip J Rosenthal (18023), Samuel L Nsobya (275219), Banek Kristin, Fred Wabwire-Mangen (18024), Kamya, Moses.R, Albert Kilian (275220), Madeline Slater (275221), Kamya Moses R, Arthur Reingold, Wabwire-Mangen Fred, Fred Wabwire-Mangen, Wabwire-Mangen, Fred, Staedke Sarah G, Sarah G Staedke, Moses R Kamya, Kristin Banek, Kironde, Fred, Slater, Madeline, Dorsey, Grant, Nsobya, Samuel L., Reingold Arthur, Ambrose Talisuna, Fred Kironde (44975), Kilian, Albert, Talisuna, Ambrose, Bakyaita, Nathan, Fred Kironde, Madeline Slater, Rosenthal, Philip J, Nsobya, Samuel L, Ambrose Talisuna (18019), Slater Madeline, Yeka, Adoke, Nsobya Samuel L, Bakyaita Nathan, Kironde Fred, Philip J Rosenthal, Talisuna Ambrose, Adoke Yeka, Samuel L Nsobya, Kamya, Moses R, Staedke, Sarah G., Nathan Bakyaita (18021), Adoke Yeka (18017)   +59 more
core   +2 more sources