Results 41 to 50 of about 1,477,269 (300)

Saleability of Anti-malarials in Private Drug Shops in Muheza, Tanzania: A Baseline study in an era of assumed Artemisinin Ccombination Therapy (ACT). [PDF]

, 2011
Artemether-lumefantrine (ALu) replaced sulphadoxine-pymimethamine (SP) as the official first-line anti-malarial in Tanzania in November 2006. So far, artemisinin combination therapy (ACT) is contra-indicated during pregnancy by the national malaria ...
Massawe Isolide S, Bygbjerg Ib C, Ib C Bygbjerg, Martha M Lemnge, Ringsted Frank M, Lemnge Martha M, Lemnge, Martha M, Isolide S Massawe, Ringsted, Frank M, Massawe, Isolide S, Bygbjerg, Ib C, Frank M Ringsted   +11 more
core   +1 more source

Electroacupuncture alleviates motor dysfunction by regulating neuromuscular junction disruption and neuronal degeneration in SOD1G93A mice

Brain Research Bulletin
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease characterized by the progressive destruction of the neuromuscular junction (NMJ) and the degeneration of motor neurons, eventually leading to atrophy and paralysis of voluntary muscles ...
Junyang Liu, Weijia Zhao, Jie Guo, Kaiwen Kang, Hua Li, Xiaohang Yang, Jie Li, Qiang Wang, Haifa Qiao   +8 more
doaj   +1 more source

Priority Setting for the Implementation of Artemisinin-Based Combination Therapy Policy in Tanzania: Evaluation Against the Accountability for Reasonableness Framework. [PDF]

, 2012
\ud Priority setting for artemisinin-based antimalarial drugs has become an integral part of malaria treatment policy change in malaria-endemic countries. Although these drugs are more efficacious, they are also more costly than the failing drugs.
Mori Amani, Kaale, E.A., Mori, Amani Thomas, Amani Thomas Mori, Kaale, Eliangiringa Amos, Mori, A.T., Kaale Eliangiringa, Eliangiringa Amos Kaale   +7 more
core   +1 more source

A Drug Combination Screen Identifies Drugs Active against Amoxicillin-induced Round Bodies of Borrelia burgdorferi Persisters from an FDA Drug Library

Frontiers in Microbiology, 2016
Although currently recommended antibiotics for Lyme disease such as doxycycline or amoxicillin cure the majority of the patients, about 10-20% of patients treated for Lyme disease may experience lingering symptoms including fatigue, pain, or joint and ...
Jie eFeng, Wanliang eShi, Shuo eZhang, David eSullivan, Paul eAuwaerter, Ying eZhang   +5 more
doaj   +1 more source

Marine Natural Products, Multitarget Therapy and Repurposed Agents in Alzheimer’s Disease

Pharmaceuticals, 2020
Alzheimer’s disease (AD) is a multifactorial disease characterized by the presence of amyloid plaques, neurofibrillary tangles, and nerve cell death that affects, mainly, older people.
Márcia Martins, Renata Silva, Madalena M. M. Pinto, Emília Sousa   +3 more
doaj   +1 more source

In Vitro and In Vivo Activity of Citral in Combination with Amphotericin B, Anidulafungin and Fluconazole against Candida auris Isolates

Journal of Fungi, 2023
Candida auris is an emerging fungal pathogen responsible for hospital outbreaks of invasive candidiasis associated with high mortality. The treatment of these mycoses is a clinical challenge due to the high resistance levels of this species to current ...
Iñigo de-la-Fuente, Andrea Guridi, Nerea Jauregizar, Elena Eraso, Guillermo Quindós, Elena Sevillano   +5 more
doaj   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Five-Feature Model for Developing the Classifier for Synergistic vs. Antagonistic Drug Combinations Built by XGBoost

Frontiers in Genetics, 2019
Combinatorial drug therapy can improve the therapeutic effect and reduce the corresponding adverse events. In silico strategies to classify synergistic vs. antagonistic drug pairs is more efficient than experimental strategies.
Xiangjun Ji, Xiangjun Ji, Weida Tong, Zhichao Liu, Tieliu Shi, Tieliu Shi   +5 more
doaj   +1 more source

Rational Engineering of a Sub-Picomolar HIV-1 Blocker

Viruses, 2022
With the aim of rationally devising a refined and potent HIV-1 blocker, the cDNA of CCL5 5p12 5m, an extremely potent CCR5 antagonist, was fused to that of C37, a gp41-targeted fusion inhibitor. The resulting CCL5 5p12 5m-C37 fusion protein was expressed
Massimiliano Secchi, Luca Vangelista
doaj   +1 more source

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source