Piloting the global subsidy: the impact of subsidized artemisinin-based combination therapies distributed through private drug shops in rural Tanzania. [PDF]
, 2009 BACKGROUND: WHO estimates that only 3% of fever patients use recommended artemisinin-based combination therapies (ACTs), partly reflecting their high prices in the retail sector from where many patients seek treatment.
Catherine Goodman +26 more
core +2 more sources
Rational deployment of antimalarial drugs in Africa: should first-line combination drugs be reserved for paediatric malaria cases? [PDF]
, 2011 Artemisinin-based combination therapy is exerting novel selective pressure upon populations of Plasmodium falciparum across Africa. Levels of resistance to non-artemisinin partner drugs differ among parasite populations, and so the artemisinins are not ...
Mackinnon, Margaret J +19 more
core +1 more source
Search for Synergistic Drug Combinations to Treat Chronic Lymphocytic Leukemia
Cells, 2022 Finding synergistic drug combinations is an important area of cancer research. Here, we sought to rationally design synergistic drug combinations with an inhibitor of BTK kinase, ibrutinib, which is used for the treatment of several types of leukemia. We
Eleonora Ela Hezkiy +10 more
doaj +1 more source
Drug combination and repurposing for cancer therapy: the example of breast cancer
Heliyon, 2021 Cancer is a set of extremely complex diseases, which are increasingly prominent today, as it affects and kills millions of people worldwide, being the subject of intense study both in its pathophysiology and therapy. Especially in women, breast cancer is
A. S. Correia, F. Gärtner, N. Vale
semanticscholar +1 more source
Deep Learning Based Anticancer Drug Combination Discovery Through Natural Compounds and Pharmaceutical Drugs [PDF]
, 2023 Drug combination therapies have shown effective performance in treating cancer through increased efficacy and circumvention of drug resistance through drug synergy.
Elton, Cao
core +1 more source
Preclinical Studies and Drug Combination of Low-Cost Molecules for Chagas Disease
Pharmaceuticals, 2022 Chagas disease is caused by the protozoan Trypanosoma cruzi (T. cruzi). It remains the major parasitic disease in Latin America and is spreading worldwide, affecting over 10 million people. Hundreds of new compounds with trypanosomicidal action have been
Elena Aguilera +16 more
doaj +1 more source
NPCDR: natural product-based drug combination and its disease-specific molecular regulation
Nucleic Acids Res., 2021 Natural product (NP) has a long history in promoting modern drug discovery, which has derived or inspired a large number of currently prescribed drugs. Recently, the NPs have emerged as the ideal candidates to combine with other therapeutic strategies to
Xueni Sun +13 more
semanticscholar +1 more source
GraphSynergy: a network-inspired deep learning model for anticancer drug combination prediction
J. Am. Medical Informatics Assoc., 2021 OBJECTIVE To develop an end-to-end deep learning framework based on a protein-protein interaction (PPI) network to make synergistic anticancer drug combination predictions.
Jian-Nan Yang +4 more
semanticscholar +1 more source
Fish Capsules: A System for High‐Throughput Screening of Combinatorial Drugs
Advanced Science, 2022 Large‐scale screening of molecules heavily relies on phenotyping of small living organisms during preclinical development. However, deep profiling candidate therapeutics on whole animals typically requires laborious manipulations and anesthetic treatment
Minghui Tang +10 more
doaj +1 more source
Frontiers in Psychiatry, 2022 Opioids and stimulants are often used in combination for both recreational and non-recreational purposes. High-efficacy mu opioid agonists generally increase the behavioral effects of stimulants, whereas opioid receptor antagonists generally attenuate ...
Mark A. Smith +16 more
doaj +1 more source