Results 51 to 60 of about 1,477,269 (300)

Willingness-to-pay for a rapid malaria diagnostic test and artemisinin-based combination therapy from private drug shops in Mukono District, Uganda. [PDF]

, 2013
In Uganda, as in many parts of Africa, the majority of the population seek treatment for malaria in drug shops as their first point of care; however, parasitological diagnosis is not usually offered in these outlets.
Cundill, Bonnie, Clarke, Sian, Mbonye, Anthony, Pedrazzoli, Debora, Yeung, Shunmay, Magnussen, Pascal, Hansen, Kristian Schultz   +6 more
core   +1 more source

In Vitro and In Vivo Effect of Amikacin and Imipenem Combinations against Multidrug-Resistant E. coli

Tropical Medicine and Infectious Disease, 2022
Introduction: The emergence of multidrug-resistant (MDR) E. coli has developed worldwide; therefore, the use of antibiotic combinations may be an effective strategy to target resistant bacteria and fight life-threatening infections. The current study was
Sara Mahmoud Farhan, Rehab Mahmoud Abd El-Baky, Salah Abdalla, Ahmed Osama EL-Gendy, Hala Rady Ahmed, Doaa Safwat Mohamed, Amr El Zawily, Ahmed Farag Azmy   +7 more
doaj   +1 more source

Rational Use of Herbal Products in Pediatric Patients Treated With Anticancer Drugs in the European Union

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot, Mathieu Corvaisier, Laurence Spiesser‐Robelet, Mylène Duplan, Isabelle Pellier, Delphine Bourneau‐Martin, Séverine Derbré   +6 more
wiley   +1 more source

Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi

Frontiers in Cellular and Infection Microbiology, 2021
Azoles such as posaconazole (Posa) are highly potent against Trypanosoma cruzi. However, when tested in chronic Chagas disease patients, a high rate of relapse after Posa treatment was observed. It appears that inhibition of T.
Marianne Rocha-Hasler, Marianne Rocha-Hasler, Marianne Rocha-Hasler, Gabriel Melo de Oliveira, Aline Nefertiti da Gama, Ludmila Ferreira de Almeida Fiuza, Anna Frieda Fesser, Anna Frieda Fesser, Monica Cal, Monica Cal, Romina Rocchetti, Romina Rocchetti, Raiza Brandão Peres, Xue Li Guan, Marcel Kaiser, Marcel Kaiser, Maria de Nazaré Correia Soeiro, Pascal Mäser, Pascal Mäser   +18 more
doaj   +1 more source

Guidelines for Pediatric Radiotherapy Simulation: A Report From the Children's Oncology Group Radiation Oncology Discipline

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei, Stephen Mihalcik, Sujith Baliga, Young Kwok, Dana Casey, Eric Ehler, Christiane Burton, John C. Breneman, Daphne A. Haas‐Kogan, Suzanne L. Wolden, Arnold C. Paulino, Nadia N. Laack, Natia Esiashvili, Sarah Milgrom, Christine Hill‐Kayser, Thomas J. Fitzgerald, John A. Kalapurakal, Chia‐Ho Hua   +17 more
wiley   +1 more source

Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria [PDF]

, 2008
Besides existing artemisinin-based combination therapies, alternative safe, effective and affordable drug combinations against falciparum malaria are needed. Methylene blue (MB) was the first synthetic antimalarial drug ever used, and recent studies have
Walter-Sack, Ingeborg, Coulibaly, Boubacar, Sié, Ali, Schirmer, R. Heiner, Zoungrana, Augustin, Meissner, Peter E., Müller, Olaf, Kouyaté, Bocar, Klose, Christina, Mockenhaupt, Frank P., Mansmann, Ulrich   +10 more
core   +1 more source

A proteomic landscape of pharmacologic perturbations for functional relevance

Journal of Pharmaceutical Analysis
Pharmacological perturbation studies based on protein-level signatures are fundamental for drug discovery. In the present study, we used a mass spectrometry (MS)-based proteomic platform to profile the whole proteome of the breast cancer MCF7 cell line ...
Zhiwei Liu, Shangwen Jiang, Bingbing Hao, Shuyu Xie, Yingluo Liu, Yuqi Huang, Heng Xu, Cheng Luo, Min Huang, Minjia Tan, Jun-Yu Xu   +10 more
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

How Sulfadoxine-Pyrimethamine (SP) was Perceived in some Rural Communities After Phasing Out Chloroquine (CQ) as a First-Line Drug for Uncomplicated Malaria in Tanzania: Lessons to Learn Towards Moving from Monotherapy to Fixed Combination Therapy. [PDF]

, 2006
Malaria is a leading cause of death in Sub-Saharan Africa. Tanzania changed its malaria treatment policy from chloroquine (CQ) to Sulphadoxine-Pyrimethamine (SP) as first line drug in August 2001. We wanted to assess the perception and behaviour about SP
Nsimba Stephen ED, StephenED Nsimba, Nsimba, Stephen E D   +2 more
core   +1 more source

A drug combination prediction framework based on graph convolutional network and heterogeneous information [PDF]

, 2022
Combination therapy, which can improve therapeutic efficacy and reduce side effects, plays an important role in the treatment of complex diseases. Yet, a large number of possible combinations among candidate compounds limits our ability to identify ...
Rao, Y, Lu, Y, Yang, Y, Chen, H
core   +1 more source