Results 11 to 20 of about 793,336 (333)

Eradication of Drug-Tolerant Mycobacterium tuberculosis 2022: Where We Stand

Microorganisms, 2023
The lungs of tuberculosis (TB) patients contain a spectrum of granulomatous lesions, ranging from solid and well-vascularized cellular granulomas to avascular caseous granulomas.
Alessio Lanni, Angelo Iacobino, Lanfranco Fattorini, Federico Giannoni   +3 more
doaj   +1 more source

Antifungal Combinations in Dermatophytes

Journal of Fungi, 2021
Dermatophytes are the most common cause of fungal infections worldwide, affecting millions of people annually. The emergence of resistance among dermatophytes along with the availability of antifungal susceptibility procedures suitable for testing ...
Lucia Brescini, Simona Fioriti, Gianluca Morroni, Francesco Barchiesi   +3 more
doaj   +1 more source

From Combinations to Single-Molecule Polypharmacology—Cromolyn-Ibuprofen Conjugates for Alzheimer’s Disease

Molecules, 2021
Despite Alzheimer’s disease (AD) incidence being projected to increase worldwide, the drugs currently on the market can only mitigate symptoms. Considering the failures of the classical paradigm “one target-one drug-one disease” in delivering effective ...
Claudia Albertini, Marina Naldi, Sabrina Petralla, Silvia Strocchi, Daniela Grifoni, Barbara Monti, Manuela Bartolini, Maria Laura Bolognesi   +7 more
doaj   +1 more source

Understanding the Clinical Use of Levosimendan and Perspectives on its Future in Oncology

Biomolecules, 2023
Drug repurposing, also known as repositioning or reprofiling, has emerged as a promising strategy to accelerate drug discovery and development. This approach involves identifying new medical indications for existing approved drugs, harnessing the ...
Eduarda Ribeiro, Nuno Vale
doaj   +1 more source

Search algorithms as a framework for the optimization of drug combinations [PDF]

, 2008
Combination therapies are often needed for effective clinical outcomes in the management of complex diseases, but presently they are generally based on empirical clinical experience.
A Wagner, AJ Viterbi, AL Barabasi, Andrew D. McCulloch, B Schmidt, CM Reidys, D Calzolari, Diego Calzolari, E Lin, EK Kemsley, F Jelinek, G Paternostro, GA Bekey, Giovanni Paternostro, GR Zimmermann, Greg Tucker-Kellogg, J Bechhoefer, J Lamb, JA Radford, Jacob D. Feala, JB Fitzgerald, JD Feala, Jennifer Schofield, JG Hardman, JG Wood, JJ Schneider, JM Toivonen, John C. Reed, JW Gargano, K Wang, Laurence Coquin, M Bohm, M Nerenberg, PG Gobbi, PK Wong, R Johannesson, R Marcus, R Palmer, R Pfeifer, RA Kloner, RA Weinberg, RP Araujo, Stefania Bruschi, V Diehl, WR Greco   +44 more
core   +8 more sources

Candyflipping and Other Combinations: Identifying Drug–Drug Combinations from an Online Forum

Frontiers in Psychiatry, 2018
Novel psychoactive substances (NPS) refer to synthetic compounds or derivatives of more widely known substances of abuse that have emerged over the last two decades.
Michael Chary, David Yi, Alex F. Manini
doaj   +1 more source

Review of Predicting Synergistic Drug Combinations

Life, 2023
The prediction of drug combinations is of great clinical significance. In many diseases, such as high blood pressure, diabetes, and stomach ulcers, the simultaneous use of two or more drugs has shown clear efficacy. It has greatly reduced the progression
Yichen Pan, Haotian Ren, Liang Lan, Yixue Li, Tao Huang   +4 more
doaj   +1 more source

Broad-Spectrum Antivirals and Antiviral Drug Combinations

Viruses, 2022
Viral diseases consistently pose a substantial economic and public health burden worldwide [...]
Valentyn Oksenych, Denis E. Kainov
doaj   +1 more source

Prevalence and patterns of higher-order drug interactions in Escherichia coli. [PDF]

, 2018
Interactions and emergent processes are essential for research on complex systems involving many components. Most studies focus solely on pairwise interactions and ignore higher-order interactions among three or more components.
Cruz-Loya, Mauricio, Damoiseaux, Robert, Kang, Tina Manzhu, Savage, Van M, Singh, Nina, Tekin, Elif, White, Cynthia, Yeh, Pamela J   +7 more
core   +2 more sources

Synergistic drug combinations from electronic health records and gene expression. [PDF]

, 2016
ObjectiveUsing electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including ...
Chen, William, Daugherty, Aaron C, Desai, Manisha, Farrington, Carl, Gomez, Scarlett L, Hastie, Trevor, Kenkare, Pragati, Kurian, Allison W, Lim, Michael, Low, Yen S, Mathur, Maya, Radin, Andrew A, Schroeder, Elizabeth A, Seto, Tina, Shah, Nigam H, Sirota, Marina, Sledge, George W, Thompson, Caroline A, Weber, Susan, Yu, Peter P   +19 more
core   +2 more sources