Results 11 to 20 of about 737,831 (320)
Broad-Spectrum Antivirals and Antiviral Drug Combinations
Viruses, 2022 Viral diseases consistently pose a substantial economic and public health burden worldwide [...]
Valentyn Oksenych, Denis E. Kainov
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Understanding the Clinical Use of Levosimendan and Perspectives on its Future in Oncology
Biomolecules, 2023 Drug repurposing, also known as repositioning or reprofiling, has emerged as a promising strategy to accelerate drug discovery and development. This approach involves identifying new medical indications for existing approved drugs, harnessing the ...
Eduarda Ribeiro, Nuno Vale
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Eradication of Drug-Tolerant Mycobacterium tuberculosis 2022: Where We Stand
Microorganisms, 2023 The lungs of tuberculosis (TB) patients contain a spectrum of granulomatous lesions, ranging from solid and well-vascularized cellular granulomas to avascular caseous granulomas.
Alessio Lanni +3 more
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Bifunctional antibiotic hybrids: A review of clinical candidates
Frontiers in Pharmacology, 2023 Antibiotic resistance is a top threat to human health and a priority across the globe. This problematic issue is accompanied by the decline of new antibiotics in the pipeline over the past 30 years.
Augustine Jing Jie Koh +6 more
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Corrigendum: Network-based prediction of anti-cancer drug combinations [PDF]
Frontiers in PharmacologyJue Jiang +4 more
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Pharmaceutics, 2022 The fast evolution of anti-tumor agents embodies a deeper understanding of cancer pathogenesis. To date, chemotherapy, targeted therapy, and immunotherapy are three pillars of the paradigm for cancer treatment. The success of immune checkpoint inhibitors
Tiancheng Zhang +3 more
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Antifungal Combinations in Dermatophytes
Journal of Fungi, 2021 Dermatophytes are the most common cause of fungal infections worldwide, affecting millions of people annually. The emergence of resistance among dermatophytes along with the availability of antifungal susceptibility procedures suitable for testing ...
Lucia Brescini +3 more
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Molecules, 2021 Despite Alzheimer’s disease (AD) incidence being projected to increase worldwide, the drugs currently on the market can only mitigate symptoms. Considering the failures of the classical paradigm “one target-one drug-one disease” in delivering effective ...
Claudia Albertini +7 more
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Search algorithms as a framework for the optimization of drug combinations [PDF]
, 2008 Combination therapies are often needed for effective clinical outcomes in the management of complex diseases, but presently they are generally based on empirical clinical experience.
A Wagner +44 more
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Prevalence and patterns of higher-order drug interactions in Escherichia coli. [PDF]
, 2018 Interactions and emergent processes are essential for research on complex systems involving many components. Most studies focus solely on pairwise interactions and ignore higher-order interactions among three or more components.
Cruz-Loya, Mauricio +7 more
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