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Drug Prescription in the Department of Medicine of a Tertiary Care Hospital according to the World Health Organization/International Network for Rational Use of Drugs Core Indicators: A Descriptive Cross-sectional Survey

Journal of Nepal Medical Association, 2021
Introduction: To establish appropriate health care services in developing countries, rationalization of drug use holds utmost importance. Drug use patterns can be found out using Core Indicators of the World Health Organisation in collaboration with the ...
Jyoti Tara Manandhar Shrestha , Saurabh Tiwari, Dilip Kumar Kushwaha, Pratigya Bhattarai, Ruchi Shrestha   +4 more
doaj   +1 more source

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen [PDF]

, 2019
The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal ...
Abante, J, Abecassis, BS, Aben, N, Aghamirzaie, D, Ahsen, ME, Aittokallio, T, Akhtari, FS, Al-lazikani, B, Alam, T, Allam, A, Allen, C, Altarawy, D, Alves, V, Amadoz, A, Anchang, B, Angel Pujana, M, Antolin, AA, Ash, JR, Ba-alawi, W, Bagheri, M, Bajic, V, Ball, G, Ballester, PJ, Baptista, D, Bare, C, Bateson, M, Bender, A, Bertrand, D, Boroevich, KA, Bosdriesz, E, Bougouffa, S, Bounova, G, Brouwer, T, Bryant, B, Bulusu, KC, Calaza, M, Calderone, A, Calza, S, Capuzzi, S, Carbonell-Caballero, J, Carlin, D, Carter, H, Castagnoli, L, Celebi, R, Cesareni, G, Chang, H, Chen, G, Chen, H, Chen, H, Cheng, L, Chernomoretz, A, Chicco, D, Cho, K-H, Cho, S, Choi, D, Choi, J, Choi, K, Choi, M, Coker, E, Combinatio, A-SD, Cortes-Ciriano, I, Cserzo, M, Cubuk, C, Curtis, C, Dang, CC, de Almeida, MP, De Cock, M, de Esch, I, de Graaf, C, De Maeyer, D, De Niz, C, de Ruiter, JR, De Troyer, E, Di Veroli, GY, Dijkstra, T, Dopazo, J, Draghici, S, Drosou, A, Dry, JR, Dumontier, M, Ehrhart, F, Eid, F-E, ElHefnawi, M, Elmarakeby, H, Engin, HB, Evelo, C, Falcao, AO, Farag, S, Fawell, S, Fernandez-Lozano, C, Fisch, K, Flobak, A, Fornari, C, Foroushani, ABK, Fotso, DC, Fourches, D, Friend, S, Frigessi, A, Gao, F, Gao, X, Garnett, MJ, Gerold, JM, Gestraud, P, Ghazoui, Z, Ghosh, S, Gillberg, J, Godoy-Lorite, A, Godynyuk, L, Godzik, A, Goldenberg, A, Gomez-Cabrero, D, Gonen, M, Gray, H, Grechkin, M, Guan, Y, Guimera, R, Guinney, J, Guney, E, Haibe-Kains, B, Han, Y, Hase, T, He, D, He, L, Heath, LS, Hellton, KH, Helmer-Citterich, M, Hidalgo, MR, Hidru, D, Hill, SM, Hochreiter, S, Hong, S, Hovig, E, Hsueh, Y-C, Hu, Z, Huang, JK, Huang, RS, Hunyady, L, Hwang, J, Hwang, TH, Hwang, W, Hwang, Y, Isayev, O, Jack, J, Jahandideh, S, Jang, IS, Jeon, M, Ji, J, Jo, Y, Kamola, PJ, Kanev, GK, Kang, J, Karacosta, L, Karimi, M, Kaski, S, Kazanov, M, Khamis, AM, Khan, SA, Kiani, NA, Kim, A, Kim, J, Kim, J, Kim, K, Kim, K, Kim, S, Kim, Y, Kim, Y, Kirk, PDW, Kitano, H, Klambauer, G, Knowles, D, Ko, M, Kohn-Luque, A, Kooistra, AJ, Kuenemann, MA, Kuiper, M, Kurz, C, Kwon, M, Laegreid, A, Lederer, S, Lee, H, Lee, J, Lee, YW, Leppaho, E, Lewis, R, Li, J, Li, L, Liley, J, Lim, WK, Lin, C, Liu, Y, Lopez, Y, Low, J, Lysenko, A, Machado, D, Madhukar, N, Malpartida, AB, Mamitsuka, H, Marabita, F, Marchal, K, Marttinen, P, Mason, D, Mason, MJ, Mazaheri, A, Mehmood, A, Mehreen, A, Menden, MP, Michaut, M, Miller, RA, Mitsopoulos, C, Modos, D, Moo, K, Motsinger-Reif, A, Movva, R, Muraru, S, Muratov, E, Mushthofa, M, Nagarajan, N, Nakken, S, Nath, A, Neto, EC, Neuvial, P, Newton, R, Nguyen, T, Ning, Z, Norman, T, Oliva, B, Olsen, C, Palmeri, A, Panesar, B, Papadopoulos, S, Park, J, Park, S, Park, S, Pawitan, Y, Peluso, D, Pendyala, S, Peng, J, Perfetto, L, Pirro, S, Plevritis, S, Politi, R, Poon, H, Porta, E, Prellner, I, Preuer, K, Ramnarine, R, Reid, JE, Reyal, F, Richardson, S, Ricketts, C, Rieswijk, L, Rocha, M, Rodriguez-Gonzalvez, C, Roell, K, Romeo Aznar, V, Rotroff, D, Rukawa, P, Sadacca, B, Saez-Rodriguez, J, Safikhani, Z, Safitri, F, Sales-Pardo, M, Sauer, S, Schlichting, M, Seoane, JA, Serra, J, Shang, M-M, Sharma, A, Sharma, H, Shen, Y, Shiga, M, Shin, M, Shkedy, Z, Shopsowitz, K, Sinai, S, Skola, D, Smirnov, P, Soerensen, IF, Soerensen, P, Song, J-H, Song, SO, Soufan, O, Spitzmueller, A, Steipe, B, Stolovitzky, G, Suphavilai, C, Szalai, B, Tamayo, SP, Tamborero, D, Tang, EKY, Tang, J, Tanoli, Z-U-R, Tarres-Deulofeu, M, Tegner, J, Thommesen, L, Tonekaboni, SAM, Tran, H, Truong, A, Tsunoda, T, Turu, G, Tzeng, G-Y, Van Daele, D, van Engelen, B, van Laarhoven, T, Van Moerbeke, M, van Westen, GJP, Verbeke, L, Videla, S, Vis, D, Vogel, R, Voronkov, A, Votis, K, Walk, OBD, Wang, A, Wang, D, Wang, H-QH, Wang, P-W, Wang, S, Wang, W, Wang, X, Wang, X, Wennerberg, K, Wernisch, L, Wessels, L, Westerman, BA, White, SR, Wijayawardena, B, Willighagen, E, Wolfinger, R, Wurdinger, T, Xie, L, Xie, S, Xu, H, Yadav, B, Yau, C, Yeerna, H, Yin, JW, Yu, M, Yu, M, Yu, T, Yun, SJ, Zakharov, A, Zamichos, A, Zanin, M, Zaslavskiy, M, Zeng, L, Zenil, H, Zhang, F, Zhang, P, Zhang, W, Zhao, H, Zhao, L, Zheng, W, Zoufir, A, Zucknick, M   +354 more
core   +21 more sources

The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers. [PDF]

, 2011
Encapsulation of drugs within nanocarriers that selectively target malignant cells promises to mitigate side effects of conventional chemotherapy and to enable delivery of the unique drug combinations needed for personalized medicine.
Ashley, Carlee E, Brinker, C Jeffrey, Brown, Page A, Carnes, Eric C, Carroll, Nick J, Carter, Mark B, Chackerian, Bryce, Dunphy, Darren R, Durfee, Paul N, Evans, Deborah G, Hanna, Tracey N, Jiang, Xingmao, Liu, Juewen, Padilla, David, Parikh, Atul N, Peabody, David S, Petsev, Dimiter N, Phillips, Brandy, Phillips, Genevieve K, Wharton, Walker, Willman, Cheryl L   +20 more
core   +2 more sources

DRUG-NEM: Optimizing drug combinations using single-cell perturbation response to account for intratumoral heterogeneity. [PDF]

, 2018
An individual malignant tumor is composed of a heterogeneous collection of single cells with distinct molecular and phenotypic features, a phenomenon termed intratumoral heterogeneity.
Anchang, Benedict, Bendall, Sean C, Davis, Kara L, Fienberg, Harris G, Karacosta, Loukia G, Nolan, Garry P, Plevritis, Sylvia K, Tibshirani, Robert, Williamson, Brian D   +8 more
core   +1 more source

Network-based prediction of drug combinations

Nature Communications, 2019
Combination therapy holds great promise, but discovery remains challenging. Here, the authors propose a method to identify efficacious drug combinations for specific diseases, and find that successful combinations tend to target separate neighbourhoods ...
Feixiong Cheng, István A. Kovács, Albert-László Barabási   +2 more
doaj   +1 more source

Multi-drug resistant Gram-negative bacteria: antibiotic-resistance and new treatment strategies [PDF]

, 2017
In this editorial, we treat the multi-drug-resistance of microorganisms such as Klebsiella pneumonia (Kp) and Acinetobacter baumanii and the issues concerning the management of these infections.
Angelis, Massimiliano De, Mascellino, Maria Teresa, Oliva, Alessandra   +2 more
core   +1 more source

Corrigendum: Network-based prediction of anti-cancer drug combinations [PDF]

Frontiers in Pharmacology
Jue Jiang, Xuxu Wei, YuKang Lu, Simin Li, Xue Xu   +4 more
doaj   +2 more sources

Improved Network Performance via Antagonism: From Synthetic Rescues to Multi-drug Combinations [PDF]

, 2010
Recent research shows that a faulty or sub-optimally operating metabolic network can often be rescued by the targeted removal of enzyme-coding genes--the exact opposite of what traditional gene therapy would suggest.
Adilson E. Motter, Baba, Blagosklonny, Bollenbach, Bourgeois, Burgard, Burgard, Cagatay, Chait, Cun, Dancey, Duarte, Edwards, Feist, Fischer, Fong, Fong, Fong, Fong, Fraenkel, Gerdes, Giaever, Goebl, Harrison, Hashimoto, Hegreness, Henry, Herring, Hilgetag, Hilgetag, Hillenmeyer, Hopkins, Huttenlocher, Huttenlocher, Isalan, Kauffman, Keiser, Kim, Kitano, Kupiec, Ma, Miller, Motter, Motter, Nishikawa, Olson, Palsson, Papp, Pharkya, Reguly, Segre, Segre, Shlomi, Timmermans, Wagner, Yeh, Yildirim, Yngvadottir, Zamboni   +58 more
core   +3 more sources

Investigating therapeutic efficacy of dacarbazine and temozolomide, alone and in combination with BRAF(V600E) siRNA in A375 human melanoma cell line [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Melanoma is one of the most aggressive and deadly skin cancers. Despite advances, effective melanoma treatment is challenging, often requiring a shift from individual therapies to combination approaches.
Fatemeh Tabandeh, Rana Moradian Tehrani, Mohammadreza Sharifi, Elmira Toopchi   +3 more
doaj   +1 more source

NLLSS: Predicting Synergistic Drug Combinations Based on Semi-supervised Learning. [PDF]

PLoS Computational Biology, 2016
Fungal infection has become one of the leading causes of hospital-acquired infections with high mortality rates. Furthermore, drug resistance is common for fungus-causing diseases.
Xing Chen, Biao Ren, Ming Chen, Quanxin Wang, Lixin Zhang, Guiying Yan   +5 more
doaj   +1 more source