Results 21 to 30 of about 943,135 (348)

Drug Prescription in the Department of Medicine of a Tertiary Care Hospital according to the World Health Organization/International Network for Rational Use of Drugs Core Indicators: A Descriptive Cross-sectional Survey

Journal of Nepal Medical Association, 2021
Introduction: To establish appropriate health care services in developing countries, rationalization of drug use holds utmost importance. Drug use patterns can be found out using Core Indicators of the World Health Organisation in collaboration with the ...
Jyoti Tara Manandhar Shrestha , Saurabh Tiwari, Dilip Kumar Kushwaha, Pratigya Bhattarai, Ruchi Shrestha   +4 more
doaj   +1 more source

Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations [PDF]

, 2014
Drug resistance, de novo and acquired, pervades cellular signaling networks (SNs) from one signaling motif to another as a result of cancer progression and/or drug intervention.
Bown, James L., Goltsov, Alexey, Goltsov, Gregory, Harrison, David J., Langdon, Simon P.   +4 more
core   +3 more sources

Search algorithms as a framework for the optimization of drug combinations [PDF]

, 2008
Combination therapies are often needed for effective clinical outcomes in the management of complex diseases, but presently they are generally based on empirical clinical experience.
A Wagner, AJ Viterbi, AL Barabasi, Andrew D. McCulloch, B Schmidt, CM Reidys, D Calzolari, Diego Calzolari, E Lin, EK Kemsley, F Jelinek, G Paternostro, GA Bekey, Giovanni Paternostro, GR Zimmermann, Greg Tucker-Kellogg, J Bechhoefer, J Lamb, JA Radford, Jacob D. Feala, JB Fitzgerald, JD Feala, Jennifer Schofield, JG Hardman, JG Wood, JJ Schneider, JM Toivonen, John C. Reed, JW Gargano, K Wang, Laurence Coquin, M Bohm, M Nerenberg, PG Gobbi, PK Wong, R Johannesson, R Marcus, R Palmer, R Pfeifer, RA Kloner, RA Weinberg, RP Araujo, Stefania Bruschi, V Diehl, WR Greco   +44 more
core   +8 more sources

Synergistic drug combinations from electronic health records and gene expression. [PDF]

, 2016
ObjectiveUsing electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including ...
Chen, William, Daugherty, Aaron C, Desai, Manisha, Farrington, Carl, Gomez, Scarlett L, Hastie, Trevor, Kenkare, Pragati, Kurian, Allison W, Lim, Michael, Low, Yen S, Mathur, Maya, Radin, Andrew A, Schroeder, Elizabeth A, Seto, Tina, Shah, Nigam H, Sirota, Marina, Sledge, George W, Thompson, Caroline A, Weber, Susan, Yu, Peter P   +19 more
core   +2 more sources

Pharmacokinetic modelling of the anti-malarial drug artesunate and its active metabolite dihydroartemisinin [PDF]

, 2012
A four compartment mechanistic mathematical model is developed for the pharmacokinetics of the commonly used anti-malarial drug artesunate and its principle metabolite dihydroartemisinin following oral administration of artesunate.
Adam J. Hall, Banks, Batty, Bergstrand, Cheng, Cheung, Cole, Godfrey, Gordi, Jacquez, John A.D. Aston, Joy, Karunajeewa, Klonis, LaCrue, Li, Li, Lindegardh, Lindegårdh, Meshnick, Michael J. Chappell, Morris, Newton, O’Neill, Rössler, Saralamba, Scholar, Seber, Starčević, Stephen A. Ward, Tan, Van Agtmael, Varma, White, WHO, WHO, Woerdenbag   +36 more
core   +2 more sources

Network-based prediction of drug combinations

Nature Communications, 2019
Combination therapy holds great promise, but discovery remains challenging. Here, the authors propose a method to identify efficacious drug combinations for specific diseases, and find that successful combinations tend to target separate neighbourhoods ...
Feixiong Cheng, István A. Kovács, Albert-László Barabási   +2 more
doaj   +1 more source

Fixed-dose versus separate drug combinations for antihypertensive treatment: literature review

Medwave, 2016
Resumen INTRODUCCIÓN La hipertensión arterial requiere de intervenciones efectivas para reducir la morbimortalidad cardiovascular. Las terapias farmacológicas han logrado alcanzar cifras óptimas de presión arterial en los afectados.
José Luis Calleja Rivero
doaj   +1 more source

Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer. [PDF]

, 2018
Dysregulation of the PI3K-AKT-mTOR signaling network is a prominent feature of breast cancers. However, clinical responses to drugs targeting this pathway have been modest, possibly because of dynamic changes in cellular signaling that drive resistance ...
A Bosch, A Katsha, A Subramanian, AA Dar, Andrei Goga, AS Nikonova, AV Statsuk, AY Choo, B MacLean, C Leroy, Cancer Genome Atlas Network., D Bankston, DA Fruman, F Janku, F Zheng, GR Anderson, H Daub, H Yang, Hayley J. Donnella, J Baselga, J Foucquier, J Hollander den, J Lehár, JA Diehl, James E. Korkola, James T. Webber, JE Ferrell Jr., JF Blake, John D. Gordan, JS Duncan, KE O’Reilly, Kevan M. Shokat, Khyati N. Shah, KJ Brewer Savannah, L Boussemart, L Lu, L Vadlakonda, LL Liu, M Bantscheff, M Barvian, M Choi, M Elkabets, M Laplante, M Piccart, M Tanaka, MJ West, MK Muellner, ML Sos, MM Martins, N Dey, N Ilic, N Volkmann, Nora Bayani, Olga Momcilovic, P Liu, PM Barr, PP Roux, QB She, R Sears, RB Corcoran, Rebecca S. Levin, RM Neve, Roman Camarda, SJ Klempner, SMA Lens, Sourav Bandyopadhyay, SR Vora, TJ Stuhlmiller, TK Nomanbhoy, Y Zwang   +69 more
core   +1 more source

Combining the Antidepressant Drugs [PDF]

BMJ, 1965
Mary F. Lockett, Gerald Milner
  +21 more sources

Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms : revival of an old drug [PDF]

, 2013
BACKGROUND: It is widely recognized that only a handful of drugs are available against soil-transmitted helminthiasis, all of which are characterized by a low efficacy against Trichuris trichiura, when administered as single doses.
Adelfio, R., Keiser, J., Silbereisen, A., Speich, B., Tritten, L., Vargas, M.   +5 more
core   +2 more sources