Results 31 to 40 of about 943,135 (348)
NLLSS: Predicting Synergistic Drug Combinations Based on Semi-supervised Learning. [PDF]
PLoS Computational Biology, 2016 Fungal infection has become one of the leading causes of hospital-acquired infections with high mortality rates. Furthermore, drug resistance is common for fungus-causing diseases.
Xing Chen +5 more
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Oncology drug-companion diagnostic combinations
Cancer Treatment and Research Communications, 2021 With the development of trastuzumab for metastatic breast cancer a new era began in cancer drug development. The drug-diagnostic codevelopment model with its clinical enrichment trial design has enabled development of target specific drugs for molecular ...
Jan Trøst Jørgensen
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Drug Combinations: Mathematical Modeling and Networking Methods
Pharmaceutics, 2019 Treatments consisting of mixtures of pharmacological agents have been shown to have superior effects to treatments involving single compounds. Given the vast amount of possible combinations involving multiple drugs and the restrictions in time and ...
Vahideh Vakil, Wade Trappe
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Frontiers in Fungal Biology, 2021 Since the earliest days of using natural remedies, combining therapies for disease treatment has been standard practice. Combination treatments exhibit synergistic effects, broadly defined as a greater-than-additive effect of two or more therapeutic ...
Hamid Gaikani +6 more
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Respiratory Medicine Case Reports, 2022 The effective therapy for pulmonary arterial hypertension (PAH) with inadequate clinical response is scarce except for lung transplantation when prostacyclin infusion is ineffective.
Mizuki Momoi +7 more
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Molecules, 2019 Malaria is an infectious disease caused by Plasmodium group. The mechanisms of antimalarial drugs DHA/CQ are still unclear today. The inhibitory effects (IC50) of single treatments with DHA/CQ or V-ATPase inhibitor Baf-A1 or combination treatments by DHA/
Tian Tang +6 more
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Long-term drug use and polypharmacy among the elderly population in the Republic of Srpska, Bosnia and Herzegovina [PDF]
Vojnosanitetski Pregled, 2016 Background/Aim. Prescription of drugs is a fundamental care component of the elderly. Elderly patients often take multiple drugs, and it is known that polypharmacy may lead to drug interactions and adverse events.
Marković-Peković Vanda, Škrbić Ranko
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, 2020 The use of drug combinations in clinical trials is increasingly common during the last years since a more favorable therapeutic response may be obtained by combining drugs.
Jiménez, José L. +2 more
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LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation [PDF]
, 2015 The actin and microtubule cytoskeletons are critically important for cancer cell proliferation, and drugs that target microtubules are widely-used cancer therapies. However, their utility is compromised by toxicities due to dose and exposure. To overcome
Baugh, Mark +18 more
core +2 more sources
Drug Interactions in Lenacapavir-Based Long-Acting Antiviral Combinations
Viruses, 2022 Long-acting (LA) anti-HIV regimens show promise for increasing dosing intervals and consequently, improving the patients’ quality of life. The first FDA-approved LA therapy is Cabenuva, which comprises rilpivirine (a non-nucleoside reverse transcriptase ...
Maria E. Cilento +3 more
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