Results 31 to 40 of about 737,831 (320)
Oncology drug-companion diagnostic combinations
Cancer Treatment and Research Communications, 2021 With the development of trastuzumab for metastatic breast cancer a new era began in cancer drug development. The drug-diagnostic codevelopment model with its clinical enrichment trial design has enabled development of target specific drugs for molecular ...
Jan Trøst Jørgensen
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Respiratory Medicine Case Reports, 2022 The effective therapy for pulmonary arterial hypertension (PAH) with inadequate clinical response is scarce except for lung transplantation when prostacyclin infusion is ineffective.
Mizuki Momoi +7 more
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Drug Combinations: Mathematical Modeling and Networking Methods
Pharmaceutics, 2019 Treatments consisting of mixtures of pharmacological agents have been shown to have superior effects to treatments involving single compounds. Given the vast amount of possible combinations involving multiple drugs and the restrictions in time and ...
Vahideh Vakil, Wade Trappe
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NLLSS: Predicting Synergistic Drug Combinations Based on Semi-supervised Learning. [PDF]
PLoS Computational Biology, 2016 Fungal infection has become one of the leading causes of hospital-acquired infections with high mortality rates. Furthermore, drug resistance is common for fungus-causing diseases.
Xing Chen +5 more
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Multi-drug resistant Gram-negative bacteria: antibiotic-resistance and new treatment strategies [PDF]
, 2017 In this editorial, we treat the multi-drug-resistance of microorganisms such as Klebsiella pneumonia (Kp) and Acinetobacter baumanii and the issues concerning the management of these infections.
Angelis, Massimiliano De +2 more
core +1 more source
Molecules, 2019 Malaria is an infectious disease caused by Plasmodium group. The mechanisms of antimalarial drugs DHA/CQ are still unclear today. The inhibitory effects (IC50) of single treatments with DHA/CQ or V-ATPase inhibitor Baf-A1 or combination treatments by DHA/
Tian Tang +6 more
doaj +1 more source
LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation [PDF]
, 2015 The actin and microtubule cytoskeletons are critically important for cancer cell proliferation, and drugs that target microtubules are widely-used cancer therapies. However, their utility is compromised by toxicities due to dose and exposure. To overcome
Baugh, Mark +18 more
core +2 more sources
Long-term drug use and polypharmacy among the elderly population in the Republic of Srpska, Bosnia and Herzegovina [PDF]
Vojnosanitetski Pregled, 2016 Background/Aim. Prescription of drugs is a fundamental care component of the elderly. Elderly patients often take multiple drugs, and it is known that polypharmacy may lead to drug interactions and adverse events.
Marković-Peković Vanda, Škrbić Ranko
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Drug Interactions in Lenacapavir-Based Long-Acting Antiviral Combinations
Viruses, 2022 Long-acting (LA) anti-HIV regimens show promise for increasing dosing intervals and consequently, improving the patients’ quality of life. The first FDA-approved LA therapy is Cabenuva, which comprises rilpivirine (a non-nucleoside reverse transcriptase ...
Maria E. Cilento +3 more
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Combinations of drugs in the Treatment of Obesity [PDF]
Pharmaceuticals, 2010 Obesity is a chronic disease associated with excess morbidity and mortality. Clinical treatment, however, currently offers disappointing results, with very high rates of weight loss failure or weight regain cycles, and only two drugs (orlistat and sibutramine) approved for long-term use.
Maria Edna de Melo +6 more
openaire +3 more sources