Results 11 to 20 of about 700,446 (274)
Scientific Reports, 2021 Small interfering RNA (siRNA) therapy is a promising epigenetic silencing strategy. However, its widespread adoption has been severely impeded by its ineffective delivery into the cellular environment.
Yong Yao Chun +8 more
doaj +1 more source
Bioengineering & Translational Medicine, 2023 Ionic liquids (ILs) attract more and more interests in improving drug transport across membrane, including transdermal, nasal, and oral delivery. However, some drawbacks of ILs impede the application in oral drug delivery, such as rapid precipitation of ...
Kaiheng Liu +9 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2021 Background Strategies to increase nucleic acid vaccine immunogenicity are needed to move towards clinical applications in oncology. In this study, we designed a new generation of DNA vaccines, encoding an engineered vesicular stomatitis virus ...
Alessandra Lopes +8 more
doaj +1 more source
Intelligent wayfinding vehicle design based on visual recognition [PDF]
arXiv, 2022 Intelligent drug delivery trolley is an advanced intelligent drug delivery equipment. Compared with traditional manual drug delivery, it has higher drug delivery efficiency and lower error rate. In this project, an intelligent drug delivery car is designed and manufactured, which can recognize the road route and the room number of the target ward ...
arxiv
An in situ dual-anchoring strategy for enhanced immobilization of PD-L1 to treat autoimmune diseases
Nature Communications, 2023 Immune checkpoints play key roles in maintaining self-tolerance. Targeted potentiation of the checkpoint molecule PD-L1 through in situ manipulation offers clinical promise for patients with autoimmune diseases.
Shenqiang Wang +9 more
doaj +1 more source
Cancer DNA vaccines: current preclinical and clinical developments and future perspectives
Journal of Experimental & Clinical Cancer Research, 2019 The recent developments in immuno-oncology have opened an unprecedented avenue for the emergence of vaccine strategies. Therapeutic DNA cancer vaccines are now considered a very promising strategy to activate the immune system against cancer. In the past,
Alessandra Lopes +2 more
doaj +1 more source
Magnetically-triggered Nanocomposite Membranes: a Versatile Platform for Triggered Drug Release [PDF]
Nano Lett., 2011, 11 (3), pp 1395-1400, 2011 Drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on-off drug release upon application (and removal) of an oscillating magnetic field.
arxiv +1 more source
Scavenger receptor A-mediated nanoparticles target M1 macrophages for acute liver injury
Asian Journal of Pharmaceutical Sciences, 2023 Acute liver injury (ALI) has an elevated fatality rate due to untimely and ineffective treatment. Although, schisandrin B (SchB) has been extensively used to treat diverse liver diseases, its therapeutic efficacy on ALI was limited due to its high ...
Rongping Zhang +10 more
doaj
Modulation of Methotrexate Release from Nano-Hydrogels via Drug-Transition Metal Complexation [PDF]
Trends in Pharmaceutical Sciences, 2020 Despite the extensive application of methotrexate (MTX) as a chemotherapeutic agent and an immune system suppressor, its therapeutic implementation has been limited due to its poor pharmacokinetics, saturable cellular transport, and insufficient response
Mahsa Taheri +5 more
doaj +1 more source
Modelling of reversible tissue electroporation and its thermal effects in drug delivery [PDF]
arXiv, 2022 Electroporation is a very useful tool for drug delivery into various diseased tissues of the human body. This technique helps to improve the clinical treatment by transferring drugs into the targeted cells rapidly. In electroporation, drug particles enter easily into the intracellular compartment through the temporarily permeabilized cell membrane due ...
arxiv