Results 81 to 90 of about 1,053,768 (311)

Self-assembly of multi-component fluorescent molecular logic gates in micelles [PDF]

open access: yes, 2016
A recent strategy for developing supramolecular logic gates in water is based on combinations of molecules via self-assembly with surfactants, which eliminates the need for time-consuming synthesis. The self-assembly of surfactants and lumophores and
Costa, Paola F. da   +2 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Targeted Delivery of Arctigenin Using Sialic Acid Conjugate-Modified Liposomes for the Treatment of Breast Cancer

open access: yesMolecules
Arctigenin (ATG) is a broad-spectrum antitumor drug with an excellent inhibitory effect on malignant tumors such as breast cancer, glioblastoma, liver cancer, and colon cancer.
Shunfang Liu   +5 more
doaj   +1 more source

Liposomal drug delivery systems and anticancer drugs [PDF]

open access: yes, 2018
Cancer is a life-threatening disease contributing to ~3.4 million deaths worldwide. There are various causes of cancer, such as smoking, being overweight or obese, intake of processed meat, radiation, family history, stress, environmental factors, and ...
Elkordy, Amal Ali   +4 more
core   +3 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Validated LC-MS/MS Method for the Determination of Scopoletin in Rat Plasma and Its Application to Pharmacokinetic Studies

open access: yesMolecules, 2015
A rapid, sensitive and selective liquid chromatography-electrospray ionization-tandem mass spectrometric method was developed and validated for the quantification of scopoletin in rat plasma.
Yingchun Zeng   +5 more
doaj   +1 more source

Drug delivery systems - Winter school on recent advances in diagnosis and management of diseases in mariculture, 7th to 27th November 2002, Course Manual [PDF]

open access: yes, 2002
Drug delivery systems are designed based on the action of the drug in the body, reaction of the body to these drugs and the active drug available in the body for therapeutic action.
Gopakumar, N
core  

Enhanced topical delivery of dexamethasone by β-cyclodextrin decorated thermoresponsive nanogels [PDF]

open access: yes, 2017
Highly hydrophilic, responsive nanogels are attractive as potential systems for the topical delivery of bioactives encapsulated in their three-dimensional polymeric scaffold. Yet, these drug carrier systems suffer from drawbacks for efficient delivery of
Bergueiro, J.   +13 more
core   +1 more source

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