Results 141 to 150 of about 779,180 (303)
PCN ReportsAim This study evaluated survival rates and examined characteristics associated with mortality among individuals with drug use disorder (DUD) enrolled in drug addiction rehabilitation facilities in Japan. Methods This longitudinal cohort study, conducted
Satomi Mizuno +4 more
doaj +1 more source
Sex Differences in Profiles and Treatment-Seeking Among Patients Visiting the Drug Dependence Treatment Center at a Psychiatric Hospital in India. [PDF]
Indian J Psychol Med, 2023 Khanra S, Mukherjee A, Munda SK.
europepmc +1 more source
Dopamine D4 receptor counteracts morphine-induced changes in M opioid receptor signaling in the striosomes of the rat caudate putamen. [PDF]
, 2015 Morphine is one of the most potent analgesic drugs used to relieve moderate to severe pain. After long-term use of morphine, neuroadaptive changes in the brain promotes tolerance, which result in a reduced sensitivity to most of its effects with ...
De-la-Calle-Martin, Adelaida +6 more
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Translational PsychiatryAddictive drugs, notably opioid drugs, have significant societal implications, yet the cellular and molecular mechanisms underpinning rewarding effects remain largely elusive.
Jie Meng +12 more
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Diagnostic Reliability and Validity of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) Chinese Version. [PDF]
Complex Psychiatry, 2021 Yang BZ +10 more
europepmc +1 more source
UNODC youth initiative: discussion guide. Draft. [PDF]
, 2011 Contents: Section 1: Perceptions about Drug Use Section 2: What is Vulnerability? Section 3: The Direct Effects of Using Drugs Section 4: Abuse of Prescription Drug Section 5: Consequences and Risks Associated with Drug Use Section 6: Prevention ...
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source