Results 91 to 100 of about 2,938,349 (358)

Identifying Illicit Drug Dealers on Instagram with Large-scale Multimodal Data Fusion [PDF]

arXiv, 2021
Illicit drug trafficking via social media sites such as Instagram has become a severe problem, thus drawing a great deal of attention from law enforcement and public health agencies. How to identify illicit drug dealers from social media data has remained a technical challenge due to the following reasons.
arxiv  

Computer-aided drug design

BMC Chemistry, 2023
AbstractComputer-Aided Drug Design tools are now an indispensable part of drug discovery that have made key contributions to the development of drugs. In this editorial, I briefly provide an overview of CADD emphasizing its potential and invite authors from academia and the pharmaceutical and biotechnology sector to present their research in this ...
openaire   +4 more sources

Simple models of protein folding and of non--conventional drug design

, 2004
While all the information required for the folding of a protein is contained in its amino acid sequence, one has not yet learned how to extract this information to predict the three--dimensional, biologically active, native conformation of a protein ...
Abkkevich V I, Anfinsen C B, Broglia R A Shakhnovich E I Tiana G, Brooks B R, Bryngelson J D, Bryngelson J D, D Provasi, Derrida B, Fersht A, Flory P J, G Tiana, Go N, Hänggi P, Itzhaki L S, Kramers H A, Lau K F, Metropolis N, Mezard M, Miyazawa S, Orland H, R A Broglia, Rost B, Shakhnovich E I, Smith H, Toulouse G, van Kampen N G   +25 more
core   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Discovery of N-benzyl hydroxypyridone carboxamides as a novel and potent antiviral chemotype against human cytomegalovirus (HCMV)

Acta Pharmaceutica Sinica B, 2022
Current drugs for treating human cytomegalovirus (HCMV) infections are limited by resistance and treatment-associated toxicities. In developing mechanistically novel HCMV antivirals, we discovered an N-benzyl hydroxypyridone carboxamide antiviral hit (8a)
Sameera Senaweera, Tiffany C. Edwards, Jayakanth Kankanala, Yan Wang, Rajkumar Lalji Sahani, Jiashu Xie, Robert J. Geraghty, Zhengqiang Wang   +7 more
doaj  

Designer drugs

Laboratory Medicine, 2023
Pesce, Amadeo J, Krock, Kevin
openaire   +2 more sources

Clinical trials with endothelin receptor antagonists: What went wrong and where can we improve? [PDF]

, 2012
In the early 1990s, within three years of cloning of endothelin receptors, orally active endothelin receptor antagonists (ERAs) were tested in humans and the first clinical trial of ERA therapy in humans was published in 1995.
Barton, Matthias, Cleland, John G., Kohan, Donald E., Rubin, Lewis J., Theodorescu, Dan   +4 more
core   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

AI-based disease risk score for community-acquired pneumonia hospitalization

iScience, 2023
Summary: Community-acquired pneumonia (CAP) is an acute infection involving the parenchyma of the lungs, which is acquired outside of the hospital. Population-wide real-world data and artificial intelligence (AI) were used to develop a disease risk score
Saeed Shakibfar, Morten Andersen, Maurizio Sessa   +2 more
doaj  

Designer drugs for discerning bugs [PDF]

Proceedings of the National Academy of Sciences, 2010
Almost all antibiotics used in clinical medicine owe their origin to natural compounds. Discovery of these compounds has traditionally been driven by an outward-looking Saganesque conviction (somewhere, something incredible is waiting to be known) that broad screening of many hundreds of species of bacteria and fungi would unearth novel antimicrobials.
openaire   +4 more sources