Results 11 to 20 of about 17,208,238 (361)
An Orally Bioavailable (Mice) Prodrug of Glutathione
Antioxidants, 2021 L-Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH), was found to be orally bioavailable in mice, and protected mice against a toxic dose of acetaminophen.
Daune L. Crankshaw +3 more
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Application of Computational Biology and Artificial Intelligence in Drug Design
International Journal of Molecular Sciences, 2022 Traditional drug design requires a great amount of research time and developmental expense. Booming computational approaches, including computational biology, computer-aided drug design, and artificial intelligence, have the potential to expedite the ...
Yue Zhang +5 more
semanticscholar +1 more source
Advances in De Novo Drug Design: From Conventional to Machine Learning Methods
International Journal of Molecular Sciences, 2021 De novo drug design is a computational approach that generates novel molecular structures from atomic building blocks with no a priori relationships. Conventional methods include structure-based and ligand-based design, which depend on the properties of ...
Varnavas D. Mouchlis +8 more
semanticscholar +1 more source
An Updated Review of Computer-Aided Drug Design and Its Application to COVID-19
BioMed Research International, 2021 The recent outbreak of the deadly coronavirus disease 19 (COVID-19) pandemic poses serious health concerns around the world. The lack of approved drugs or vaccines continues to be a challenge and further necessitates the discovery of new therapeutic ...
A. Gurung +4 more
semanticscholar +1 more source
Nature Communications, 2020 Chemical modification of proteins can be used to decipher function or use that function for therapeutic purposes. Here, the authors insert synthetic peptides via tandem protein trans-splicing to add post-translational modifications or non-canonical amino
K. K. Khoo +9 more
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Frontiers in Pharmacology, 2021 Formononetin is one of the main active compounds of traditional Chinese herbal medicine Astragalus membranaceus. However, disposition of formononetin via sulfonation pathway remains undefined.
Fanye Liu +10 more
doaj +1 more source
Avidity in antibody effector functions and biotherapeutic drug design
Nature reviews. Drug discovery, 2022 Antibodies are the cardinal effector molecules of the immune system and are being leveraged with enormous success as biotherapeutic drugs. A key part of the adaptive immune response is the production of an epitope-diverse, polyclonal antibody mixture ...
S. Oostindie +3 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2020 High expression of programmed death-ligand-1 (PD-L1) in hepatocellular carcinoma (HCC) cells usually inhibits the proliferation and functions of T cells, leading to immune suppression in tumor microenvironment.
Xiao Wang +11 more
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Scientific Reports, 2022 The blood–brain barrier (BBB) greatly limits the delivery of protein-based drugs into the brain and is a major obstacle for the treatment of brain disorders. Targeting the transferrin receptor (TfR) is a strategy for transporting protein-based drugs into
Andrés de la Rosa +8 more
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Drug Design by Pharmacophore and Virtual Screening Approach
Pharmaceuticals, 2022 Computer-aided drug discovery techniques reduce the time and the costs needed to develop novel drugs. Their relevance becomes more and more evident with the needs due to health emergencies as well as to the diffusion of personalized medicine ...
D. Giordano +3 more
semanticscholar +1 more source