Results 11 to 20 of about 3,066,996 (254)
Drug Design and Delivery for Intracellular Bacteria: Emerging Paradigms. [PDF]
Drug Dev ResOlowu BI +5 more
europepmc +3 more sources
Virtual chemical reactions for drug design [PDF]
, 2009 Two methods for the fast, fragment-based combinatorial molecule assembly were developed. The software COLIBREE® (Combinatorial Library Breeding) generates candidate structures from scratch, based on stochastic optimization [1].
E Proschak +8 more
core +2 more sources
Computational structure‐based drug design: Predicting target flexibility [PDF]
, 2018 The role of molecular modeling in drug design has experienced a significant revamp in the last decade. The increase in computational resources and molecular models, along with software developments, is finally introducing a competitive advantage in early
Ding X. +4 more
core +2 more sources
Cancer Cell International, 2019 Background DKK1 has been reported to act as a tumor suppressor in breast cancer. However, the mechanism of DKK1 inhibits breast cancer migration and invasion was still unclear.
Jie Niu +9 more
doaj +1 more source
Alzheimer’s Research & Therapy, 2020 Background Amyloid β (Aβ)-directed immunotherapy has shown promising results in preclinical and early clinical Alzheimer’s disease (AD) trials, but successful translation to late clinics has failed so far.
Kathrin Gnoth +16 more
doaj +1 more source
Identifying and preventing health problems among young drug-misusing offenders [PDF]
, 2013 Purpose – The purpose of this paper is to identify the health problems and treatment needs of drug-misusing offenders and to draw out the implications of the findings for health education and prevention.
Judith Aldridge +2 more
core +2 more sources
Extended two-stage adaptive designswith three target responses forphase II clinical trials [PDF]
, 2017 We develop a nature-inspired stochastic population-based algorithm and call it discrete particle swarm optimization tofind extended two-stage adaptive optimal designs that allow three target response rates for the drug in a phase II trial.Our proposed ...
Kim, Seongho, Wong, Weng Kee
core +1 more source
Molecules, 2021 Discovery of compound 1 as a Zika virus (ZIKV) inhibitor has prompted us to investigate its 7H-pyrrolo[2,3-d]pyrimidine scaffold, revealing structural features that elicit antiviral activity.
Ruben Soto-Acosta +5 more
doaj +1 more source
Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design [PDF]
, 2009 The main task of the medicinal chemist is to design molecules that interact specifically with derailed or degenerating processes in a diseased organism, translating the available knowledge of pathobiochemical and physiological data into chemically ...
Bruijnincx, Pieter C. A., Sadler, P. J.
core +1 more source
Journal of Cheminformatics, 2023 Lipophilicity is a fundamental physical property that significantly affects various aspects of drug behavior, including solubility, permeability, metabolism, distribution, protein binding, and toxicity.
Yitian Wang +13 more
doaj +1 more source