Results 251 to 260 of about 17,208,238 (361)

Structure-Based Drug Design of Novel Heterocyclic Scaffolds as TgCDPK1 Inhibitors. [PDF]

ChemMedChem
Kooner AS, Norman M, Vilza I, Mannino MP, Dhason MS, Helander J, Patil S, Sibley LD, Janetka JW.   +8 more
europepmc   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Multi-Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations. [PDF]

Pharmacol Res Perspect
Hossain MS, Hussain MH.
europepmc   +1 more source

A Bayesian Semi-Mechanistic Dose-Finding Design for Phase I Drug Combination Trials in Oncology

Yisheng Li, Chao Yang
openalex   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Fragment-based drug design of a bacterial kinase inhibitor capable of increasing the antibiotic sensitivity of clinical isolates. [PDF]

Commun Chem
Kowalewski J, Deutscher R, Richardoz M, Tomaszczyk M, Gelin M, Labesse G, Hausch F, Wright GD, Dunyach-Remy C, Guichou JF, Lionne C.   +10 more
europepmc   +1 more source

DESIGN AND EVALUATION OF COLON SPECIFIC DRUG DELIVERY SYSTEM OF MESALAMINE

Krishnaveni. B, Srinivas. N, Vivek Sagar. P, Mamatha. T, Chandra Shekhar Reddy. B*   +4 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Beginning of a new era of synthetic messenger RNA therapeutics: Comprehensive insights on mRNA drug design, development and applications. [PDF]

Exp Biol Med (Maywood)
Heendeniya SN, Chen S, Bhatti S, Zahra QUA, Rahimizadeh K, Poudel BH, Wilton SD, Veedu RN.   +7 more
europepmc   +1 more source

A REVIEW ARTICLE ON QSAR APPLICATION AND ADVANCEMENT IN DRUG DESIGN

Miss. Prerna S. Deodhagale1*, Prof. Suraj P. Rajurkar2, Miss. Shruti P. Kadam3, Mr. Priyanshu Y. Chaudhari4, Miss. Sakshi B. Deshmukh5, Mr. Nikhil R. Rathod6
openalex   +1 more source