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Exploring the ethical issues posed by AI and big data technologies in drug development. [PDF]
Front Public HealthFan Y, Wu Y, Wang Z.
europepmc +3 more sources
Pharmaceuticals, 2023 Antibiotics have revolutionized medicine, saving countless lives since their discovery in the early 20th century. However, the origin of antibiotics is now overshadowed by the alarming rise in antibiotic resistance.
Ghazala Muteeb +3 more
semanticscholar +1 more source
Trials, 2023 The COVID-19 pandemic has had an unprecedented and disruptive impact on people’s health and lives worldwide. In addition to burdening people’s health in the short-term in the form of infection, illness, and mortality, there has been an enormous negative ...
Kelsey McDonald +6 more
doaj +1 more source
Human disease models in drug development
Nature Reviews Bioengineering, 2023 Biomedical research is undergoing a paradigm shift towards approaches centred on human disease models owing to the notoriously high failure rates of the current drug development process.
Anna Loewa, James J Feng, S. Hedtrich
semanticscholar +1 more source
Cyclic Peptides for Drug Development.
Angewandte Chemie, 2023 Cyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development as well as other applications, ranging from research tools to food additives.
Xinjian Ji +2 more
semanticscholar +1 more source
BMC Medical Research Methodology, 2022 Background Missing data may lead to loss of statistical power and introduce bias in clinical trials. The Covid-19 pandemic has had a profound impact on patient health care and on the conduct of cancer clinical trials.
Corinne Jamoul +6 more
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New frontiers in immune checkpoint B7-H3 (CD276) research and drug development
Molecular Cancer, 2023 B7-H3 (CD276), a member of the B7 family of proteins, is a key player in cancer progression. This immune checkpoint molecule is selectively expressed in both tumor cells and immune cells within the tumor microenvironment.
A. Getu +5 more
semanticscholar +1 more source
Communications Biology, 2021 Yen et al use tissue-specific PP2A knockout mice to show that PP2A in LepR positive mesenchymal stem cells positively regulates endochondral ossification. They find that PP2A dephosphorylates Runx2 and BRD4, thereby playing a major role in positively and
Yu-Ting Yen +3 more
doaj +1 more source
Alzheimer's disease drug development pipeline: 2023
Alzheimer's & Dementia, 2023 Drugs that prevent the onset, slow progression, or improve cognitive and behavioral symptoms of Alzheimer's disease (AD) are needed.
J. Cummings +5 more
semanticscholar +1 more source
Nature Communications, 2021 Microsatellite instability (MSI), caused by deficiency of the DNA mismatch repair system, has been associated with improved response to immune checkpoint blockade (ICB).
Yu-Ting Yen +9 more
doaj +1 more source