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Trials, 2023 The COVID-19 pandemic has had an unprecedented and disruptive impact on people’s health and lives worldwide. In addition to burdening people’s health in the short-term in the form of infection, illness, and mortality, there has been an enormous negative ...
Kelsey McDonald +6 more
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Drug Development: Stages of Drug Development [PDF]
Journal of Pharmacovigilance, 2015 New drug development program for the different compound is initiated because there is a disease or clinical condition without suitable pharmacotherapeutic products available. New drug development can proceed along varied pathways for different compounds.
Khalid O. Alfarouk, Gamal Osman Elhassa
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BMC Medical Research Methodology, 2022 Background Missing data may lead to loss of statistical power and introduce bias in clinical trials. The Covid-19 pandemic has had a profound impact on patient health care and on the conduct of cancer clinical trials.
Corinne Jamoul +6 more
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Communications Biology, 2021 Yen et al use tissue-specific PP2A knockout mice to show that PP2A in LepR positive mesenchymal stem cells positively regulates endochondral ossification. They find that PP2A dephosphorylates Runx2 and BRD4, thereby playing a major role in positively and
Yu-Ting Yen +3 more
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Nature Communications, 2021 Microsatellite instability (MSI), caused by deficiency of the DNA mismatch repair system, has been associated with improved response to immune checkpoint blockade (ICB).
Yu-Ting Yen +9 more
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PPAR Research, 2021 According to the Center for Disease Control and Prevention (CDC), the coronavirus disease 2019, a respiratory viral illness linked to significant morbidity, mortality, production loss, and severe economic depression, was the third-largest cause of death ...
Mahdi Ftouh +5 more
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Drugs in Development for Malaria [PDF]
Drugs, 2018 The last two decades have seen a surge in antimalarial drug development with product development partnerships taking a leading role. Resistance of Plasmodium falciparum to the artemisinin derivatives, piperaquine and mefloquine in Southeast Asia means new antimalarials are needed with some urgency.
Ashley, E, Phyo, A
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TRPV3 in Drug Development [PDF]
Pharmaceuticals, 2016 Transient receptor potential vanilloid 3 (TRPV3) is a member of the TRP (Transient Receptor Potential) super-family. It is a relatively underexplored member of the thermo-TRP sub-family (Figure 1), however, genetic mutations and use of gene knock-outs and selective pharmacological tools are helping to provide insights into its role and therapeutic ...
Lisa Broad +5 more
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Conversion of Aquaculture Waste into Biomedical Wealth: Chitin and Chitosan Journey
Advances in Materials Science and Engineering, 2022 Biowaste originating from aquaculture sector represents a potential feedstock to produce value-added substances and materials like chitin and chitosan. They are the long chain polymers of N-acetylglucosamine polymers with huge industrial and biomedical ...
Jerrine Joseph +8 more
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Scientific Reports, 2021 Long-term stability of monoclonal antibodies to be used as biologics is a key aspect in their development. Therefore, its possible early prediction from accelerated stability studies is of major interest, despite currently being regarded as not ...
Drago Kuzman +5 more
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