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Trials, 2023 The COVID-19 pandemic has had an unprecedented and disruptive impact on people’s health and lives worldwide. In addition to burdening people’s health in the short-term in the form of infection, illness, and mortality, there has been an enormous negative ...
Kelsey McDonald +6 more
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BMC Medical Research Methodology, 2022 Background Missing data may lead to loss of statistical power and introduce bias in clinical trials. The Covid-19 pandemic has had a profound impact on patient health care and on the conduct of cancer clinical trials.
Corinne Jamoul +6 more
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Communications Biology, 2021 Yen et al use tissue-specific PP2A knockout mice to show that PP2A in LepR positive mesenchymal stem cells positively regulates endochondral ossification. They find that PP2A dephosphorylates Runx2 and BRD4, thereby playing a major role in positively and
Yu-Ting Yen +3 more
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Nature Communications, 2021 Microsatellite instability (MSI), caused by deficiency of the DNA mismatch repair system, has been associated with improved response to immune checkpoint blockade (ICB).
Yu-Ting Yen +9 more
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PPAR Research, 2021 According to the Center for Disease Control and Prevention (CDC), the coronavirus disease 2019, a respiratory viral illness linked to significant morbidity, mortality, production loss, and severe economic depression, was the third-largest cause of death ...
Mahdi Ftouh +5 more
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Conversion of Aquaculture Waste into Biomedical Wealth: Chitin and Chitosan Journey
Advances in Materials Science and Engineering, 2022 Biowaste originating from aquaculture sector represents a potential feedstock to produce value-added substances and materials like chitin and chitosan. They are the long chain polymers of N-acetylglucosamine polymers with huge industrial and biomedical ...
Jerrine Joseph +8 more
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Scientific Reports, 2021 Long-term stability of monoclonal antibodies to be used as biologics is a key aspect in their development. Therefore, its possible early prediction from accelerated stability studies is of major interest, despite currently being regarded as not ...
Drago Kuzman +5 more
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mAbs, 2023 Excipients are added to biopharmaceutical formulations to enhance protein stability and enable the development of robust formulations with acceptable physicochemical properties, but the mechanism by which they confer stability is not fully understood ...
Chunting Zhang +11 more
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Immuno-oncology combinations: raising the tail of the survival curve
Cancer Biology & Medicine, 2016 There have been exponential gains in immuno-oncology in recent times through the development of immune checkpoint inhibitors. Already approved by the U.S.
Samuel J. Harris +3 more
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Journal of Ovarian Research, 2022 Background The Ayurvedic system of medicine mentions the use of seeds of Bryonopsis laciniosa (L.) Naud. (also known as Shivlingi due to their unique structure resembling a ‘Shivling’) for treating sexual dysfunction, impaired fertility, and as a general
Acharya Balkrishna +4 more
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