Results 91 to 100 of about 5,239,733 (368)
The role of microglial P2X7: modulation of cell death and cytokine release
Journal of Neuroinflammation, 2017 Background ATP-gated P2X7 is a non-selective cation channel, which participates in a wide range of cellular functions as well as pathophysiological processes including neuropathic pain, immune response, and neuroinflammation.
Yingbo He +3 more
doaj +1 more source
Drug Discovery–-A History [PDF]
Journal of the Royal Society of Medicine, 2005 I must thank Dr Kamran Abbasi for inviting me to review this book because if I had seen it on the shelf in a bookshop I would almost certainly have passed it by; and, in doing so, I would have missed a book of great merit and considerable scholarship.
openaire +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Marine DrugsEchinoderms, a diverse group of marine invertebrates including starfish, sea urchins, and sea cucumbers, have been recognized as prolific sources of structurally diverse natural products.
Shuangyu Li +5 more
doaj +1 more source
Innovation Experiences from Africa-Led Drug Discovery at the Holistic Drug Discovery and Development (H3D) Centre [PDF]
, 2022 Vinayak Singh +3 more
openalex +1 more source
DrugBank: a comprehensive resource for in silico drug discovery and exploration
Nucleic Acids Res., 2005 DrugBank is a unique bioinformatics/cheminformatics resource that combines detailed drug (i.e. chemical) data with comprehensive drug target (i.e. protein) information.
D. Wishart +7 more
semanticscholar +1 more source
Chemistry & Biology, 2012 Data security and privacy are central to the success of these cloud-based tools. “One can easily make your microscope or telescope as small or as large as you want to in terms of permissions to maintain security and maximally mine the data,” says CDD's Bunin.
openaire +2 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Drug Discovery Today, 2021 Enzymes are essential, physiological catalysts involved in all processes of life, including metabolism, cellular signaling and motility, as well as cell growth and division. They are attractive drug targets because of the presence of defined substrate-binding pockets, which can be exploited as binding sites for pharmaceutical enzyme inhibitors ...
openaire +2 more sources