Results 171 to 180 of about 568,926 (318)

Target Engagement Assays in Early Drug Discovery. [PDF]

J Med Chem
St John-Campbell S, Bhalay G.
europepmc   +1 more source

New Drug Discovery in the Postgenomic Era: From Genomics to Proteomics

, 2000
Stephen M. Stahl
openalex   +2 more sources

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Editorial: Application of PKPD modeling in drug discovery and development. [PDF]

Front Pharmacol
Ren HC, Zhu X, Hao K, Le SY.
europepmc   +1 more source

The Oceans and Human Health: The Discovery and Development of Marine-Derived Drugs [PDF]

, 2001
Shirley A. Pomponi
openalex   +1 more source

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

Molecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun, Ching‐Fang Yu, Sheng‐Yan Wu, Wei‐Chung Cheng, Chi‐Shiun Chiang, Fang‐Hsin Chen   +5 more
wiley   +1 more source

A single gene mutation predicts response to immune checkpoint blockade in ovarian clear cell carcinoma

Molecular Oncology, EarlyView.
Loss‐of‐function mutations in the scaffold subunit of protein phosphatase 2A (PP2A), PPP2R1A, sensitize ovarian clear cell carcinoma to immune checkpoint blockade (ICB) by enhancing the interferon gamma response and promoting antitumor immune cell infiltration.
Matheus Henrique Dias, René Bernards
wiley   +1 more source

A Perspective on the Strategic Application of Deconstruction-Reconstruction in Drug Discovery. [PDF]

J Med Chem
Blackwell JH, Michaelides IN, Gibault F.
europepmc   +1 more source

Targeting of myosin light chain kinase in vasculr smooth muscle cells, and its implication for the drug discovery

, 2000
Kazuhiro Kohama
openalex   +2 more sources

The Integration of High Throughput Technologies for Drug Discovery [PDF]

, 2001
Gregory P. Sabbatini, William A. Shirley, David L. Coffen   +2 more
openalex   +1 more source