Results 21 to 30 of about 1,411,950 (341)
Computational structure‐based drug design: Predicting target flexibility [PDF]
, 2018 The role of molecular modeling in drug design has experienced a significant revamp in the last decade. The increase in computational resources and molecular models, along with software developments, is finally introducing a competitive advantage in early
Ding X. +4 more
core +2 more sources
Prediction of the permeability of neutral drugs inferred from their solvation properties [PDF]
, 2015 Determination of drug absorption is an important component of the drug discovery and development process in that it plays a key role in the decision to promote drug candidates to clinical trials.
Milanetti, Edoardo +2 more
core +1 more source
Screening a protein kinase inhibitor library against Plasmodium falciparum
Malaria Journal, 2017 Background Protein kinases have been shown to be key drug targets, especially in the area of oncology. It is of interest to explore the possibilities of protein kinases as a potential target class in Plasmodium spp., the causative agents of malaria ...
Irene Hallyburton +12 more
doaj +1 more source
Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics. [PDF]
, 2020 Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for regenerative therapy, disease modeling, and drug discovery.
Chandy, Mark +2 more
core
Journal of Biomedical Science, 2017 Background GPR88 is an orphan G protein-coupled receptor highly expressed in the striatum and is implicated in basal ganglia-associated disorders. However, the receptor functions of GPR88 are still largely unknown due to the lack of potent and selective ...
Ann M. Decker +6 more
doaj +1 more source
Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni [PDF]
, 2015 Schistosomiasis, one of the world's greatest neglected tropical diseases, is responsible for over 280,000 human deaths per annum. Praziquantel, developed in the 1970s, has high efficacy, excellent tolerability, few and transient side effects, simple ...
Altamura, Sergio +5 more
core +3 more sources
Molecular Brain, 2021 Aim We have previously reported that cambinol (DDL-112), a known inhibitor of neutral sphingomyelinase-2 (nSMase2), suppressed extracellular vesicle (EV)/exosome production in vitro in a cell model and reduced tau seed propagation.
Chunni Zhu +12 more
doaj +1 more source
Benchmarking network propagation methods for disease gene identification [PDF]
, 2019 In-silico identification of potential target genes for disease is an essential aspect of drug target discovery. Recent studies suggest that successful targets can be found through by leveraging genetic, genomic and protein interaction information.
Barrett, Steven J. +5 more
core +2 more sources
Streptococcal dTDP-L-rhamnose biosynthesis enzymes:functional characterization and lead compound identification [PDF]
, 2019 Biosynthesis of the nucleotide sugar precursor dTDP-L-rhamnose is critical for the viability and virulence of many human pathogenic bacteria, including Streptococcus pyogenes (Group A Streptococcus; GAS), Streptococcus mutans and Mycobacterium ...
Afd Chemical Biology and Drug Discovery +13 more
core +2 more sources
Scientific Reports, 2022 While the prevalence of breast cancer metastasis in the brain is significantly higher in triple negative breast cancers (TNBCs), there is a lack of novel and/or improved therapies for these patients. Monoacylglycerol lipase (MAGL) is a hydrolase involved
Othman Benchama +5 more
doaj +1 more source