Results 31 to 40 of about 5,975,518 (353)
Conversion of Aquaculture Waste into Biomedical Wealth: Chitin and Chitosan Journey
Advances in Materials Science and Engineering, 2022 Biowaste originating from aquaculture sector represents a potential feedstock to produce value-added substances and materials like chitin and chitosan. They are the long chain polymers of N-acetylglucosamine polymers with huge industrial and biomedical ...
Jerrine Joseph +8 more
doaj +1 more source
Advances in covalent drug discovery
Nature reviews. Drug discovery, 2022 Covalent drugs have been used to treat diseases for more than a century, but tools that facilitate the rational design of covalent drugs have emerged more recently.
L. Boike +2 more
semanticscholar +1 more source
Screening a protein kinase inhibitor library against Plasmodium falciparum
Malaria Journal, 2017 Background Protein kinases have been shown to be key drug targets, especially in the area of oncology. It is of interest to explore the possibilities of protein kinases as a potential target class in Plasmodium spp., the causative agents of malaria ...
Irene Hallyburton +12 more
doaj +1 more source
Computational structure‐based drug design: Predicting target flexibility [PDF]
, 2018 The role of molecular modeling in drug design has experienced a significant revamp in the last decade. The increase in computational resources and molecular models, along with software developments, is finally introducing a competitive advantage in early
Ding X. +4 more
core +2 more sources
Artificial intelligence to deep learning: machine intelligence approach for drug discovery
Molecular diversity, 2021 Drug designing and development is an important area of research for pharmaceutical companies and chemical scientists. However, low efficacy, off-target delivery, time consumption, and high cost impose a hurdle and challenges that impact drug design and ...
Rohan Gupta +5 more
semanticscholar +1 more source
Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics. [PDF]
, 2020 Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for regenerative therapy, disease modeling, and drug discovery.
Chandy, Mark +2 more
core
Prediction of the permeability of neutral drugs inferred from their solvation properties [PDF]
, 2015 Determination of drug absorption is an important component of the drug discovery and development process in that it plays a key role in the decision to promote drug candidates to clinical trials.
Milanetti, Edoardo +2 more
core +1 more source
Nucleic Acids Res., 2021 Drug discovery relies on the knowledge of not only drugs and targets, but also the comparative agents and targets. These include poor binders and non-binders for developing discovery tools, prodrugs for improved therapeutics, co-targets of therapeutic ...
Ying Zhou +7 more
semanticscholar +1 more source
Journal of Biomedical Science, 2017 Background GPR88 is an orphan G protein-coupled receptor highly expressed in the striatum and is implicated in basal ganglia-associated disorders. However, the receptor functions of GPR88 are still largely unknown due to the lack of potent and selective ...
Ann M. Decker +6 more
doaj +1 more source
Streptococcal dTDP-L-rhamnose biosynthesis enzymes:functional characterization and lead compound identification [PDF]
, 2019 Biosynthesis of the nucleotide sugar precursor dTDP-L-rhamnose is critical for the viability and virulence of many human pathogenic bacteria, including Streptococcus pyogenes (Group A Streptococcus; GAS), Streptococcus mutans and Mycobacterium ...
Afd Chemical Biology and Drug Discovery +13 more
core +2 more sources