Results 31 to 40 of about 1,411,950 (341)
Parasites & Vectors, 2016 Background In the fight against malaria, the discovery of chemical compounds with a novel mode of action and/or chemistry distinct from currently used drugs is vital to counteract the parasite’s known ability to develop drug resistance. Another desirable
Sabine Fletcher +6 more
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A novel anti-NGF PEGylated Fab’ provides analgesia with lower risk of adverse effects
mAbs, 2023 Nerve growth factor (NGF) has emerged as a key driver of pain perception in several chronic pain conditions, including osteoarthritis (OA), and plays an important role in the generation and survival of neurons.
Yukari Koya +8 more
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Ligand-based virtual screening using binary kernel discrimination [PDF]
, 2005 This paper discusses the use of a machine-learning technique called binary kernel discrimination (BKD) for virtual screening in drug- and pesticide-discovery programmes.
Beining Chen +14 more
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Hot-spot analysis for drug discovery targeting protein-protein interactions [PDF]
, 2018 Introduction: Protein-protein interactions are important for biological processes and pathological situations, and are attractive targets for drug discovery. However, rational drug design targeting protein-protein interactions is still highly challenging.
Fernández-Recio, Juan, Rosell, Mireia
core +2 more sources
Drug discovery FAQs: workflows for answering multidomain drug discovery questions
Drug Discovery Today, 2015 Modern data-driven drug discovery requires integrated resources to support decision-making and enable new discoveries. The Open PHACTS Discovery Platform (http://dev.openphacts.org) was built to address this requirement by focusing on drug discovery questions that are of high priority to the pharmaceutical industry.
Chichester +6 more
openaire +4 more sources
Edible Pueraria lobata-Derived Exosomes Promote M2 Macrophage Polarization
Molecules, 2022 Pueraria lobata (known as Gegen) is an edible and medicinal herb that is a nutritious medicine food homology plant in China. Previous studies indicated that P. lobata plays an essential role in controlling cytokines.
Jiaqi Wu +9 more
doaj +1 more source
Systems analysis of host-parasite interactions. [PDF]
, 2015 Parasitic diseases caused by protozoan pathogens lead to hundreds of thousands of deaths per year in addition to substantial suffering and socioeconomic decline for millions of people worldwide.
Jamshidi, Neema +3 more
core +1 more source
Capturing mixture composition: an open machine-readable format for representing mixed substances
Journal of Cheminformatics, 2019 We describe a file format that is designed to represent mixtures of compounds in a way that is fully machine readable. This Mixfile format is intended to fill the same role for substances that are composed of multiple components as the venerable Molfile ...
Alex M. Clark +3 more
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Antiplasmodial activity of the natural product compounds alstonine and himbeline
International Journal for Parasitology: Drugs and Drug Resistance, 2021 Malaria, caused by Plasmodium parasites, continues to be a devastating global health issue. Despite a decline in malaria related deaths over the last decade, overall progress has plateaued.
M.S.J. Arnold +5 more
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Plant chemical genetics : from phenotype-based screens to synthetic biology [PDF]
, 2017 The treatment of a biological system with small molecules to specifically perturb cellular functions is commonly referred to as chemical biology. Small molecules are used commercially as drugs, herbicides, and fungicides in different systems, but in ...
Dejonghe, Wim, Russinova, Eugenia
core +3 more sources