Results 31 to 40 of about 5,239,733 (368)
m6A modification: recent advances, anticancer targeted drug discovery and beyond
Molecular Cancer, 2022 Abnormal N6-methyladenosine (m6A) modification is closely associated with the occurrence, development, progression and prognosis of cancer, and aberrant m6A regulators have been identified as novel anticancer drug targets.
Lijuan Deng +10 more
semanticscholar +1 more source
Fibronectin extra domain A as a drug delivery targeting epitope for rheumatoid arthritis
Advances in Rheumatology, 2022 Objectives To assess the ability of monoclonal antibodies (mAbs) specific for fibronectin extra-domain A (FnEDA) to target diseased tissues of mouse collagen induced arthritis (mCIA) models.
Victor Z. Sun +13 more
doaj +1 more source
Modulating biomolecular condensates: a novel approach to drug discovery
Nature reviews. Drug discovery, 2022 In the past decade, membraneless assemblies known as biomolecular condensates have been reported to play key roles in many cellular functions by compartmentalizing specific proteins and nucleic acids in subcellular environments with distinct properties ...
Diana M. Mitrea +4 more
semanticscholar +1 more source
Cheminformatics Models for Inhibitors of Schistosoma mansoni Thioredoxin Glutathione Reductase
The Scientific World Journal, 2014 Schistosomiasis is a neglected tropical disease caused by a parasite Schistosoma mansoni and affects over 200 million annually. There is an urgent need to discover novel therapeutic options to control the disease with the recent emergence of drug ...
Sonam Gaba +3 more
doaj +1 more source
Conversion of Aquaculture Waste into Biomedical Wealth: Chitin and Chitosan Journey
Advances in Materials Science and Engineering, 2022 Biowaste originating from aquaculture sector represents a potential feedstock to produce value-added substances and materials like chitin and chitosan. They are the long chain polymers of N-acetylglucosamine polymers with huge industrial and biomedical ...
Jerrine Joseph +8 more
doaj +1 more source
Artificial intelligence in cancer target identification and drug discovery
Signal Transduction and Targeted Therapy, 2022 Artificial intelligence is an advanced method to identify novel anticancer targets and discover novel drugs from biology networks because the networks can effectively preserve and quantify the interaction between components of cell systems underlying ...
Yujie You +7 more
semanticscholar +1 more source
Journal of Translational Medicine, 2016 Background Angiopoietin-2 (Ang-2), a ligand of the Tie-2 receptor, plays an important role in maintaining endothelial cells and in destabilizing blood vessels. Collateral artery growth (arteriogenesis) is a key adaptive response to arterial occlusion. It
Xiaoyong Tan +11 more
doaj +1 more source
Deep learning in drug discovery: an integrative review and future challenges
Artificial Intelligence Review, 2022 Recently, using artificial intelligence (AI) in drug discovery has received much attention since it significantly shortens the time and cost of developing new drugs.
Heba Askr +5 more
semanticscholar +1 more source
Anticancer Drug Discovery [PDF]
JNCI Journal of the National Cancer Institute, 1991 The National Cancer Institute's (NCI's) human tumor cell line panel for screening potential new anticancer drugs is now operational (/). Its implementation and the demonstration of its feasibility represent a technical and organizational tour de force.
openaire +2 more sources
Screening a protein kinase inhibitor library against Plasmodium falciparum
Malaria Journal, 2017 Background Protein kinases have been shown to be key drug targets, especially in the area of oncology. It is of interest to explore the possibilities of protein kinases as a potential target class in Plasmodium spp., the causative agents of malaria ...
Irene Hallyburton +12 more
doaj +1 more source