Results 251 to 260 of about 13,561,957 (307)

An Alternate Method for Estimating the Dose-Response Relationships of Neuromuscular Blocking Drugs

Anesthesia & Analgesia, 2000
Slopes of the dose-response relationships for all available neuromuscular blocking drugs appear to be essentially parallel and to approximate a log-dose/logit value of 4.75. We tested the possibility of estimating both 50% effective dose (ED(50)) and 95% effective dose (ED(95)) values from a single dose-response data point when that slope is postulated.
A F, Kopman, M M, Klewicka, G G, Neuman
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Pharmacogenetics and Genetic Factors in Drug Dose-Response Relationships

2023
Abstract Pharmacogenetics and pharmacogenomics are related areas of research that aim to determine the relationship between genotypic variation, including changes in gene expression, and variations in drug response seen across patient groups. Understanding the genetic bases of variability in drug response due to altered pharmacokinetics (
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The multiple propensity score for analysis of dose–response relationships in drug safety studies

Pharmacoepidemiology and Drug Safety, 2001
AbstractIn order to detect adverse drug reactions, large observational drug safety studies are necessary as randomized clinical trials rarely have enough power. However, in order to obtain reliable results the issue of confounding, especially confounding by indication, should be addressed.
Wang, Jixian, Donnan, Peter T., Steinke, Douglas, MacDonald, Thomas M.   +3 more
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Treatment Intensity and Reduction in Drug Use for Cocaine-Dependent Methadone Patients: A Dose-Response Relationship

Journal of Psychoactive Drugs, 1995
This study examined the impact of treatment intensity on cocaine use. Seventy-seven cocaine-using methadone patients were enrolled in a six-month, structured, manual-driven, cognitive-behavioral treatment program. Sessions consisted of five individual and/or group sessions per week.
Andrew Rosenblum, Stephen Magura, Michael Palij   +2 more
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Dose-response relationships with antihypertensive drugs

Pharmacology & Therapeutics, 1992
A variety of antihypertensive drugs have been introduced into clinical practice at excessively high dose. Examples include most thiazide diuretics, propranolol, oxprenolol, atenolol, methyldopa, hydralazine and captopril. These very high doses have usually resulted from studies in which doses have been increased at regular intervals until the desired ...
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Dose–Response Relationship and Threshold Drug Dosage Identification for a Novel Hybrid Mechanical-Thrombolytic System with an Ultra-Low Dose Patch

Cellular and Molecular Bioengineering, 2021
Ischemic stroke treatment has advanced in the last two decades and intravenous thrombolysis is now considered the standard of care for selected patients. Recanalization can also be achieved by mechanical endovascular treatment for patients with large vessel occlusions.
Qin, Zhen, Chon, Chi Hang, Kwok, Ching Kwong, Woo, Peter Yat Ming, Lam, David Chuen Chun   +4 more
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