Results 261 to 270 of about 13,561,957 (307)
Some of the next articles are maybe not open access.
AAPS PharmSciTech, 2023
The objective of this study is to investigate the dose-response relationship between various concentrations of permeation enhancers (PEs) and their ability to enhance drug release from a polymer matrix, utilizing an innovative parameter known as release enhancement efficiency (K). Additionally, the molecular mechanism underlying dynamic enhancement was
Jiuheng Ruan +3 more
openaire +2 more sources
The objective of this study is to investigate the dose-response relationship between various concentrations of permeation enhancers (PEs) and their ability to enhance drug release from a polymer matrix, utilizing an innovative parameter known as release enhancement efficiency (K). Additionally, the molecular mechanism underlying dynamic enhancement was
Jiuheng Ruan +3 more
openaire +2 more sources
Dose‐response relationship characterization in current anti‐hypertensive drug development
Clinical Pharmacology & Therapeutics, 2003Clinical Pharmacology & Therapeutics (2003) 73, P68–P68; doi:
J. V. Gobburu, R. J. Lipicky
openaire +1 more source
Drug Action: Target Tissue, Dose-Response Relationships, and Receptors
1972In the complex processes of drug action three main phases can be distinguished (Fig. 1): the pharmaceutical phase, the pharmacokinetic phase and the pharmacodynamic phase. They form a suitable frame for the discussion of the chemical basis of drug action.
E. J. Ariëns, A. M. Simonis
openaire +1 more source
The American Journal of Medicine, 1989
Based on pooled data from three randomized placebo-controlled dose-finding studies in a total of 489 patients, the dose-response relationship for efficacy and adverse events was estimated, using the Michaelis-Menten equation: Effect = maximal effect multiplied by dose/constant plus dose. Three conclusions were derived from the pooled data: (1) A marked
K, Simonsen, C D, Sundstedt
openaire +2 more sources
Based on pooled data from three randomized placebo-controlled dose-finding studies in a total of 489 patients, the dose-response relationship for efficacy and adverse events was estimated, using the Michaelis-Menten equation: Effect = maximal effect multiplied by dose/constant plus dose. Three conclusions were derived from the pooled data: (1) A marked
K, Simonsen, C D, Sundstedt
openaire +2 more sources
Journal of Biopharmaceutical Statistics, 2015
Clinical trials often involve comparing 2-4 doses or regimens of an experimental therapy with a control treatment. These studies might occur early in a drug development process, where the aim might be to demonstrate a basic level of proof (the so-called proof of concept (PoC) studies), at a later stage, to help establish a dose or doses that should be ...
David, Ohlssen, Amy, Racine
openaire +2 more sources
Clinical trials often involve comparing 2-4 doses or regimens of an experimental therapy with a control treatment. These studies might occur early in a drug development process, where the aim might be to demonstrate a basic level of proof (the so-called proof of concept (PoC) studies), at a later stage, to help establish a dose or doses that should be ...
David, Ohlssen, Amy, Racine
openaire +2 more sources
Journal of Clinical Pharmacology, 2012
The contribution of specific psychotropic drugs to fall risk in patients with dementia has not been quantified precisely until now. The authors evaluated the dose‐response relationship between psychotropic drugs and falls in nursing home residents with dementia.
Tischa van der Cammen +2 more
exaly +3 more sources
The contribution of specific psychotropic drugs to fall risk in patients with dementia has not been quantified precisely until now. The authors evaluated the dose‐response relationship between psychotropic drugs and falls in nursing home residents with dementia.
Tischa van der Cammen +2 more
exaly +3 more sources
2021
The human disease tuberculosis (TB) is the leading cause of death from a single infectious agent. A quarter of the world's population is estimated to be latently infected. Drug development and screening is slow and costly. We have developed a physiologically relevant assay to screen drugs against TB when inside immune cells.
Samantha, Donnellan +3 more
openaire +2 more sources
The human disease tuberculosis (TB) is the leading cause of death from a single infectious agent. A quarter of the world's population is estimated to be latently infected. Drug development and screening is slow and costly. We have developed a physiologically relevant assay to screen drugs against TB when inside immune cells.
Samantha, Donnellan +3 more
openaire +2 more sources
Drug Metabolism and Disposition, 1991
A monoclonal antibody was used to study the dose-response relationship for antibody-mediated redistribution of tricyclic antidepressants (TCA) in rats. The antibody (anti-TCA) was an IgG1 with Ka = 3.0 x 10(8) M-1 for desipramine (DMI) and 2.2 x 10(8) M-1 for imipramine (IMI).
P R, Pentel +6 more
openaire +2 more sources
A monoclonal antibody was used to study the dose-response relationship for antibody-mediated redistribution of tricyclic antidepressants (TCA) in rats. The antibody (anti-TCA) was an IgG1 with Ka = 3.0 x 10(8) M-1 for desipramine (DMI) and 2.2 x 10(8) M-1 for imipramine (IMI).
P R, Pentel +6 more
openaire +2 more sources
The Journal of Pharmacology and Experimental Therapeutics, 1988
We have developed a 2-week bioassay that quantitates the effect of immunosuppressive drugs on organ allograft rejection. This assay is not only rapid and reliable, but also simple and relatively inexpensive and sparing of test substances. We refined the method by which neonatal mouse hearts are transplanted into pouches in the pinnae of ears of adult ...
G, Babany +3 more
openaire +2 more sources
We have developed a 2-week bioassay that quantitates the effect of immunosuppressive drugs on organ allograft rejection. This assay is not only rapid and reliable, but also simple and relatively inexpensive and sparing of test substances. We refined the method by which neonatal mouse hearts are transplanted into pouches in the pinnae of ears of adult ...
G, Babany +3 more
openaire +2 more sources
Naunyn-Schmiedeberg's Archives of Pharmacology, 2007
The objective of this study was to characterize the anticonvulsant and acute adverse-effect potentials of topiramate (TPM) and gabapentin (GBP)-two second-generation antiepileptic drugs administered alone and in combination in the maximal electroshock (MES)-induced seizures and chimney test in mice.
openaire +2 more sources
The objective of this study was to characterize the anticonvulsant and acute adverse-effect potentials of topiramate (TPM) and gabapentin (GBP)-two second-generation antiepileptic drugs administered alone and in combination in the maximal electroshock (MES)-induced seizures and chimney test in mice.
openaire +2 more sources