Sequential dose-dense single agent chemotherapy for locally advanced breast cancer [PDF]
Archive of Oncology, 2003 Chemotherapy of breast cancer is still the area of intensive research. Based on mathematical model of tumor cell growth kinetics, articulated by Larry Norton, novel concept of chemotherapy in breast cancer was launched and it implies dose-densification ...
Vrbić Svetislav +3 more
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Tacrolimus concentration/dose ratio as a therapeutic drug monitoring strategy: The influence of gender and comedication [PDF]
Vojnosanitetski Pregled, 2015 Background/Aim. A combination of tacrolimus and other drugs such as corticosteroids has been commonly used immunosuppresive regimens. On the other hand, there is a growing body of evidence that male and female may differ in their response to the
Rančić Nemanja +6 more
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Targeted randomization dose optimization trials enable fractional dosing of scarce drugs.
PLoS ONE, 2023 Administering drug at a dose lower than that used in pivotal clinical trials, known as fractional dosing, can stretch scarce resources. Implementing fractional dosing with confidence requires understanding a drug's dose-response relationship.
Philip S Boonstra +2 more
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Dose-response relationship in phase I clinical trials: A European Drug Development Network (EDDN) collaboration study. [PDF]
Journal of Clinical Oncology, 2011 Abstract Introduction: Because a dose–response relationship is characteristic of conventional chemotherapy, this concept is widely used for the development of novel cytotoxic (CTX) drugs. However, the need to reach the MTD to obtain optimal benefit with molecularly targeted agents (MTA) is controversial.
Victor Moreno Garcia +19 more
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Compound optimal designs for percentile estimation in dose-response models with restricted design intervals [PDF]
, 2005 In dose-response studies, the dose range is often restricted due to ethics concerns over drug toxicity and/or efficacy, particularly when human subjects are involved.
Zhu, Wei +2 more
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Dose-Response Relationship between Antimicrobial Drugs and Livestock-Associated MRSA in Pig Farming1
Emerging Infectious Diseases, 2015 The farming community can be a vehicle for introduction of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) in hospitals. During 2011-2013, an 18-month longitudinal study aimed at reducing the prevalence of LA-MRSA was conducted on 36 pig farms in the Netherlands.
Dorado-García, Alejandro +6 more
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Antibiotics, 2022 Pharmacokinetics and pharmacodynamics are areas in pharmacology related to different themes in the pharmaceutical sciences, including therapeutic drug monitoring and different stages of drug development.
Laiz Campos Pereira +5 more
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Sugammadex ED90 dose to reverse the rocuronium neuromuscular blockade in obese patients
Revista do Colégio Brasileiro de CirurgiõesObjective: to determine the ED90 (minimum effective dose in 90% of patients) of sugammadex for the reversal of rocuronium-induced moderate neuromuscular blockade (NMB) in patients with grade III obesity undergoing bariatric surgery.
MAURO PRADO DA SILVA +5 more
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Evaluation of the anticoagulant effect of vitamin K antagonists in patients with non-valvular atrial fibrilation [PDF]
Vojnosanitetski Pregled, 2020 Background/Aim. Despite the introduction of new oral anticoagulants (dabigatran, rivoroxaban, apixaban), vitamin K antagonists (VKA), such as warfarin and acenocoumarol are still the most widely used oral anticoagulants for the treatment of nonvalvular ...
Stanojković Zoran +6 more
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Frontiers in Pharmacology, 2014 Although many antipsychotics can reasonably control positive symptoms in schizophrenia, patients’ return to society is often hindered by negative symptoms and cognitive deficits.
Hugo eGeerts +4 more
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