Results 41 to 50 of about 13,561,957 (307)
Dose calculations for [131I] meta-iodobenzylguanidine-induced bystander effects
, 2014 Targeted radiotherapy is a potentially useful treatment for some cancers and may be potentiated by bystander effects. However, without estimation of absorbed dose, it is difficult to compare the effects with conventional external radiation treatment ...
R. J. Mairs +17 more
core +1 more source
Two-compartment pharmacokinetic model of itraconazole after single oral dose administration - gender differences [PDF]
Vojnosanitetski PregledBackground/Aim. Itraconazole (ICZ) is a widely used antifungal drug with hypervariable pharmacokinetics (PK), which is the result of the molecule’s nature itself, as well as the influence of multiple factors.
Miljković Milijana +4 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko +5 more
wiley +1 more source
Estimating the turnover time of high intravenous intake of vitamin C [PDF]
Archive of Oncology, 2011 Background: Intravenous dosing is generally recognized to be the only effective means of maintaining a high concentration of vitamin C in the plasma.
Wong Alfred
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess +5 more
wiley +1 more source
Cardiac toxicity of Triptergium wilfordii Hook F. may correlate with its inhibition to hERG channel
Heliyon, 2019 Tripterygium wilfordii Hook F. (TWHF) is a Chinese traditional medicine with cardiac toxicities. However, the mechanism of acute cardiac toxicity is not very clear.
Wei Zhao +9 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Dose-response relationship between dietary ALA(A), DHA(B), ETA (C), EPA(D), DHA(E) intake and CHD.
, 2023 Dose-response relationship between dietary ALA(A), DHA(B), ETA (C), EPA(D), DHA(E) intake and CHD.
Mengjie Zhao (11219926) +4 more
core +1 more source
Dose optimisation and scarce resource allocation: two sides of the same coin
BMJ Open, 2022 Objective A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines.Summary of key data The vast majority of drug development and ...
Govind Persad +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source